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Index > Protein center > AMER2(Gene name) > Human
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  • AMER2 (Gene name),
  • APC membrane recruitment protein 2 (Protein name ),  AMER2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AMER2(FAM123A);
    Protein name:
    APC membrane recruitment protein 2(Amer2);
    Alternative:
    Protein FAM123A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with APC.
    Function:
    Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Translocates to the cell membrane following binding to PtdIns(4,5)P2.
    Protein Attributes:
    Sequence length:
    671
    Sequence:
    50:
    METSRSRGGG | GAVSERGGAG | ASVGVCRRKA | EAGAGTGTLA | ADMDLHCDCA | 
    100:
    AETPAAEPPS | GKINKAAFKL | FKKRKSGGTM | PSIFGVKNKG | DGKSSGPTGL | 
    150:
    VRSRTHDGLA | EVLVLESGRK | EEPRGGGDSG | GGGGGRPNPG | PPRAAGPGGG | 
    200:
    SLASSSVAKS | HSFFSLLKKN | GRSENGKGEP | VDASKAGGKQ | KRGLRGLFSG | 
    250:
    MRWHRKDKRA | KAEAAEGRAP | GGGLILPGSL | TASLECVKEE | TPRAAREPEE | 
    300:
    PSQDAPRDPA | GEPAGGEEVP | APADRAPARS | CREAEGLAHP | GDTGARGEDA | 
    350:
    AGHRRAEPGP | GEVRTAEDAS | RTGAVPVKTV | PLVDSEGGSG | RAPAAPDPAS | 
    400:
    VDPPSDPSAD | RICLMFSDVT | SLKSFDSLTG | CGDIIADQEE | EAGPSCDKHV | 
    450:
    PGPGKPALSK | KNPGVVAYQG | GGEEMASPDE | VDDTYLQEFW | DMLSQTEEQG | 
    500:
    PEPQEGAAKV | AAALETKVVP | ETPKDTRCVE | AAKDASSVKR | RRLNRIPIEP | 
    550:
    HPKEEPKHPE | KEQQEGVPNS | DEGYWDSTTP | GPEEDSSSSG | KKAGIPRDSY | 
    600:
    SGDALYDLYA | DPDGSPATLP | GGKDNEETSS | LSRLKPVSPG | TITCPLRTPG | 
    650:
    SLLKDSKIPI | SIKHLTNLPS | SHPVVHQQPS | RSEMPRTKIP | VSKVLVRRVS | 
    671:
    NRGLAGTTIR | ATACHDSAKK | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Amer2
    ELISA Kit for Human Amer2
    ELISA Kit for Human Amer2
    CLIA Kit for Human Amer2
    CLIA Kit for Human Amer2
    CLIA Kit for Human Amer2
    Polyclonal Antibody for Human Amer2
    Polyclonal Antibody for Human Amer2
    Polyclonal Antibody for Human Amer2
    Monoclonal Antibody for Human Amer2
    Monoclonal Antibody for Human Amer2
    Monoclonal Antibody for Human Amer2
    Protein for Human Amer2
    Protein for Human Amer2
    Protein for Human Amer2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-671 (ISOFORM 1)
      tissue: Brain.
      tissue: Cerebellum.
    2. 2.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-671 (ISOFORM 2)
      tissue: Brain.
      tissue: Eye.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-457
    5. 5.
      "AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane."
      Grohmann A. , Tanneberger K. , Alzner A. , Schneikert J. , Behrens J.
      J. Cell Sci.120:3738-3747(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APC
    6. 6.
      "The WTX/AMER1 gene family: evolution, signature and function."
      Boutet A. , Comai G. , Schedl A.
      BMC Evol. Biol.10:280-280(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE FAMILY
    7. 7.
      "Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning."
      Pfister A.S. , Tanneberger K. , Schambony A. , Behrens J.
      J. Biol. Chem.287:1734-1741(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PTDINS(4,5)P2-BINDING;INTERACTION WITH APC
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