Gene name:
AMER2 (FAM123A) ;
Protein name:
APC membrane recruitment protein 2 (Amer2) ;
Alternative:
Protein FAM123A ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with APC.
Function:
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Protein Attributes:
50:
METSRSRGGG | GAVSERGGAG | ASVGVCRRKA | EAGAGTGTLA | ADMDLHCDCA |
100:
AETPAAEPPS | GKINKAAFKL | FKKRKSGGTM | PSIFGVKNKG | DGKSSGPTGL |
150:
VRSRTHDGLA | EVLVLESGRK | EEPRGGGDSG | GGGGGRPNPG | PPRAAGPGGG |
200:
SLASSSVAKS | HSFFSLLKKN | GRSENGKGEP | VDASKAGGKQ | KRGLRGLFSG |
250:
MRWHRKDKRA | KAEAAEGRAP | GGGLILPGSL | TASLECVKEE | TPRAAREPEE |
300:
PSQDAPRDPA | GEPAGGEEVP | APADRAPARS | CREAEGLAHP | GDTGARGEDA |
350:
AGHRRAEPGP | GEVRTAEDAS | RTGAVPVKTV | PLVDSEGGSG | RAPAAPDPAS |
400:
VDPPSDPSAD | RICLMFSDVT | SLKSFDSLTG | CGDIIADQEE | EAGPSCDKHV |
450:
PGPGKPALSK | KNPGVVAYQG | GGEEMASPDE | VDDTYLQEFW | DMLSQTEEQG |
500:
PEPQEGAAKV | AAALETKVVP | ETPKDTRCVE | AAKDASSVKR | RRLNRIPIEP |
550:
HPKEEPKHPE | KEQQEGVPNS | DEGYWDSTTP | GPEEDSSSSG | KKAGIPRDSY |
600:
SGDALYDLYA | DPDGSPATLP | GGKDNEETSS | LSRLKPVSPG | TITCPLRTPG |
650:
SLLKDSKIPI | SIKHLTNLPS | SHPVVHQQPS | RSEMPRTKIP | VSKVLVRRVS |
671:
NRGLAGTTIR | ATACHDSAKK | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Chicken
Human
ELISA Kit for Human Amer2
ELISA Kit for Human Amer2
ELISA Kit for Human Amer2
Polyclonal Antibody for Human Amer2
Polyclonal Antibody for Human Amer2
Polyclonal Antibody for Human Amer2
Monoclonal Antibody for Human Amer2
Monoclonal Antibody for Human Amer2
Monoclonal Antibody for Human Amer2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-671 (ISOFORM 1)
tissue :
Brain .
tissue :
Cerebellum .
2.
"The DNA sequence and analysis of human chromosome 13."
Dunham A.
,
Matthews L.H.
,
Burton J.
,
Ashurst J.L.
,
Howe K.L.
,
Ashcroft K.J.
,
Beare D.M.
,
Burford D.C.
,
Hunt S.E.
,
Griffiths-Jones S.
,
Jones M.C.
,
Keenan S.J.
,
Oliver K.
,
Scott C.E.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Andrews D.T.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Bannerjee R.
,
Barlow K.F.
,
Bates K.
,
Beasley H.
,
Bird C.P.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burrill W.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clamp M.E.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.C.
,
Cobley V.
,
Collins J.E.
,
Corby N.
,
Coville G.J.
,
Deloukas P.
,
Dhami P.
,
Dunham I.
,
Dunn M.
,
Earthrowl M.E.
,
Ellington A.G.
,
Faulkner L.
,
Frankish A.G.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gilbert J.G.R.
,
Gilson C.J.
,
Ghori J.
,
Grafham D.V.
,
Gribble S.M.
,
Griffiths C.
,
Hall R.E.
,
Hammond S.
,
Harley J.L.
,
Hart E.A.
,
Heath P.D.
,
Howden P.J.
,
Huckle E.J.
,
Hunt P.J.
,
Hunt A.R.
,
Johnson C.
,
Johnson D.
,
Kay M.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.J.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Lloyd C.
,
Loveland J.E.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
McLaren S.J.
,
McMurray A.
,
Milne S.
,
Moore M.J.F.
,
Nickerson T.
,
Palmer S.A.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phillimore B.
,
Porter K.M.
,
Rice C.M.
,
Searle S.
,
Sehra H.K.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.
,
Steward C.A.
,
Sycamore N.
,
Tester J.
,
Thomas D.W.
,
Tracey A.
,
Tromans A.
,
Tubby B.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
Whitehead S.L.
,
Willey D.L.
,
Wilming L.
,
Wray P.W.
,
Wright M.W.
,
Young L.
,
Coulson A.
,
Durbin R.M.
,
Hubbard T.
,
Sulston J.E.
,
Beck S.
,
Bentley D.R.
,
Rogers J.
,
Ross M.T.
more...
Nature428:522-528(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-671 (ISOFORM 2)
tissue :
Brain .
tissue :
Eye .
4.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] THR-457
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH APC
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GENE FAMILY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;PTDINS(4,5)P2-BINDING;INTERACTION WITH APC