E3 ubiquitin-protein ligase AMFR (Protein name
), AMFR_MOUSE from NCBI database.
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General Annotation
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Antigen Annotation
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Gene name:
Amfr;
Protein name:
E3 ubiquitin-protein ligase AMFR;
Alternative:
Autocrine motility factor receptor(AMF receptor);
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with UBE2G2/UBC7 through a region distinct from the RING finger. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with RNF5.
Function:
E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol (By similarity). Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: INTERACTION WITH VCP IN THE VCP/P97-AMFR/GP78 COMPLEX;FUNCTION;SUBCELLULAR LOCATION
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Cited for: INTERACTION WITH NGLY1; PSMC1; SAKS1; RAD23B AND VCP
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN UBIQUITINATION OF MISFOLDED PROTEINS;INTERACTION WITH RNF5
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-542;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]