ANP32A ELISA Kit for Human(Homo sapiens) | EIAab.comANP32A ELISA Kit for Human(Homo sapiens)

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ANP32A (Gene name),

Acidic leucine-rich nuclear phosphoprotein 32 family member A (Protein name ), AN32A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ANP32A(C15orf1;LANP;MAPM;PHAP1);

Protein name:

Acidic leucine-rich nuclear phosphoprotein 32 family member A;

Alternative:

Leucine-rich acidic nuclear protein(LANP);Acidic nuclear phosphoprotein pp32;Potent heat-stable protein phosphatase 2A inhibitor I1PP2A;Mapmodulin;Putative HLA-DR-associated protein I(PHAPI);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1.

Function:

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.

Subcellular Location:

Nucleus Cytoplasm Endoplasmic reticulum Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm.

Protein Attributes:

Sequence length:

249

Sequence:

50:

100:

150:

200:

249:

EDVSGEEEED | EEGYNDGEVD | DEEDEEELGE | EERGQKRKRE | PEDEGEDDD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.458747

KEGG:

hsa:8125

String:

P39687

MIM:

600832

STRING:

9606.ENSP00000417864

SMR:

P39687

Uniprot:

P39687

FOR

ELISA Kit for Human Acidic leucine-rich nuclear phosphoprotein 32 family member A

CLIA Kit for Human Acidic leucine-rich nuclear phosphoprotein 32 family member A

Polyclonal Antibody for Human Acidic leucine-rich nuclear phosphoprotein 32 family member A

Monoclonal Antibody for Human Acidic leucine-rich nuclear phosphoprotein 32 family member A

Protein for Human Acidic leucine-rich nuclear phosphoprotein 32 family member A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII."
Vaesen M. , Barnikol-Watanabe S. , Goetz H. , Adil Awni L. , Cole T. , Zimmermann B. , Kratzin H.D. , Hilschmann N.
Biol. Chem. Hoppe-Seyler375:113-126(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 1-26; 29-47; 71-97 AND 100-161
tissue: B-cell lymphoma.
2.

"Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A."
Li M. , Makkinje A. , Damuni Z.
Biochemistry35:6998-7002(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 7-12 AND 29-44
tissue: Kidney.
3.

"Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci."
Chen T.-H. , Brody J.R. , Romantsev F.E. , Yu J.-G. , Kayler A.E. , Voneiff E. , Kuhajda F.P. , Pasternack G.R.
Mol. Biol. Cell7:2045-2056(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1."
Matilla A. , Koshy B.T. , Cummings C.J. , Isobe T. , Orr H.T. , Zoghbi H.Y.
Nature389:974-978(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau."
Tsujio I. , Zaidi T. , Xu J. , Kotula L. , Grundke-Iqbal I. , Iqbal K.
FEBS Lett.579:363-372(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Brain.
7.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Synovium.
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lymph.
11.

"Identification of sequences required for inhibition of oncogene-mediated transformation by pp32."
Brody J.R. , Kadkol S.S. , Mahmoud M.A. , Rebel J.M. , Pasternack G.R.
J. Biol. Chem.274:20053-20055(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
12.

"Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the Set oncoprotein."
Seo S.-B. , McNamara P. , Heo S. , Turner A. , Lane W.S. , Chakravarti D.
Cell104:119-130(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THE INHAT COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
13.

"Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks."
Beresford P.J. , Zhang D. , Oh D.Y. , Fan Z. , Greer E.L. , Russo M.L. , Jaju M. , Lieberman J.
J. Biol. Chem.276:43285-43293(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SET
14.

"Tumor suppression and potentiation by manipulation of pp32 expression."
Bai J. , Brody J.R. , Kadkol S.S. , Pasternack G.R.
Oncogene20:2153-2160(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Delineation of mRNA export pathways by the use of cell-permeable peptides."
Gallouzi I.-E. , Steitz J.A.
Science294:1895-1901(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ELAVL1;SUBCELLULAR LOCATION
16.

"Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor."
Fan Z. , Beresford P.J. , Oh D.Y. , Zhang D. , Lieberman J.
Cell112:659-672(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SET COMPLEX
17.

"Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A."
Fan Z. , Beresford P.J. , Zhang D. , Xu Z. , Novina C.D. , Yoshida A. , Pommier Y. , Lieberman J.
Nat. Immunol.4:145-153(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
18.

"The Anp32 family of proteins containing leucine-rich repeats."
Matilla A. , Radrizzani M.
Cerebellum4:7-18(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE FAMILY;NOMENCLATURE
19.

"The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death."
Chowdhury D. , Beresford P.J. , Zhu P. , Zhang D. , Sung J.S. , Demple B. , Perrino F.W. , Lieberman J.
Mol. Cell23:133-142(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SET COMPLEX
20.

"The role of LANP and ataxin 1 in E4F-mediated transcriptional repression."
Cvetanovic M. , Rooney R.J. , Garcia J.J. , Toporovskaya N. , Zoghbi H.Y. , Opal P.
EMBO Rep.8:671-677(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH E4F1
21.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15 AND SER-17;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins."
Huyton T. , Wolberger C.
Protein Sci.16:1308-1315(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-149;LEUCINE-RICH REPEATS

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