Protein name:
Anaphase-promoting complex subunit 2 (APC2) ;
Alternative:
Cyclosome subunit 2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
The APC/C is composed of at least 12 subunits (By similarity). Interacts with NEUROD2.
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
Subcellular Location:
N/A
Protein Attributes:
50:
MEAEGVAVAA | AAAAAAAAAT | IIASDDCDSR | PGQELLVAWN | TVSTGLVPPA |
100:
ALGLASSRTS | GAVPPKEEEL | RAAVEVLRGH | GLHSVLEEWF | VEVLQNDLQG |
150:
NIATEFWNAI | ALRENSVDEP | QCLGLLLDAF | GLLESRLDPY | LHSLELLEKW |
200:
TRLGLLMGAG | AQGLREKVHT | MLRGVLFFST | PRTFQEMVQR | LYGRFLRVYM |
250:
QSKRKGEGGT | DPELEGELDS | RYARRRYYRL | LQSPLCAGCG | SDKQQCWCRQ |
300:
ALEQFNQLSQ | VLHRLSLLER | VCAEAVTTTL | HQVTRERMED | RCRGEYERSF |
350:
LREFHKWIER | VVGWLGKVFL | QDNPTRPTSP | EAGNTLRRWR | CHVQRFFYRI |
400:
YATLRIEELF | SIIRDFPDSR | PAIEDLKYCL | ERTDQRQQLL | VSLKVALETR |
450:
LLHPGVNTCD | IITLYISAIK | ALRVLDPSMV | ILEVACEPIR | RYLRTREDTV |
500:
RQIVAGLTGD | SDGTGDLAVE | LSKTDPACLE | TGQDSEDDSG | EPEDWVPDPV |
550:
DADPVKSSSK | RRSSDIISLL | VSIYGSKDLF | INEYRSLLAD | RLLHQFSFSP |
600:
EREIRNVELL | KLRFGEAPMH | FCEVMLKDMA | DSRRINANIR | EEDEKRPVEE |
650:
QPPFGVYAVI | LSSEFWPPFK | DEKLEVPEDI | RAALDVYCKK | YEKLKAMRTL |
700:
SWKHTLGLVT | MDVELADRTL | SVAVTPVQAV | VLLYFQNQAS | WTLEELSKVV |
750:
KMPVALLRRR | MSVWLQQGVL | REEPPGTFSV | IEEERPQDRD | NMVLIDSDDE |
800:
SDSGMASQAD | QKEEELLLFW | AYIQAMLTNL | ESLSLERIYS | MLRMFVMTGP |
837:
ALAEIDLQEL | QGYLQKKVRD | QQLIYSAGVY | RLPKNSN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Polyclonal Antibody for Mouse APC2
Polyclonal Antibody for Mouse APC2
Monoclonal Antibody for Mouse APC2
Monoclonal Antibody for Mouse APC2
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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References
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Epididymis .
2.
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PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-825;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Mast cell .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NEUROD2