Protein name:
Angiopoietin-2 (ANG-2) ;
Alternative:
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Function:
Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Subcellular Location:
Secreted
Protein Attributes:
50:
MWQIVFFTLS | CDLVRAAAYN | NFRRSMDSIG | RRQYQVQHGS | CSYTFLLPET |
100:
DNCRSPGSYV | PNAVQRDAPL | DYDDSVQRLQ | VLENIMENNT | QWLIKLENYI |
150:
QDNMKKEMVE | MQQNAVQNQT | AVMIEIGTNL | LNQTAEQTRK | LTDVEAQVLN |
200:
QTTRLELQLL | EHSLSTNKLE | KQILDQTSEI | NKLQDKNSFL | EKKVLDMEDK |
250:
HIVQLRSIKE | EKDQLQVLVS | KQNSIIEELE | KQLVTATVNN | SVLQKQQHDL |
300:
METVHSLLTM | ISPSKSPKDT | FVAKEEQIIY | RDCAEVFKSG | LTTNGIYTLT |
350:
FPNSTEEIKA | YCDMETSGGG | WTVIQRREDG | SVDFQRTWKE | YKVGFGNPSG |
400:
EHWLGNEFVF | QVTNQQPYVL | KIHLKDWEGN | EAYSLYEHFY | LSGEELNYRI |
450:
HLKGLTGTAG | KISSISQPGN | DFSTKDADND | KCICKCSQML | TGGWWFDACG |
495:
PSNLNGMYYP | QRQNTNKFNG | IKWYYWKGSG | YSLKGTTMMI | RPADF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
Dog
Polyclonal Antibody for Dog ANG-2
Polyclonal Antibody for Dog ANG-2
Polyclonal Antibody for Dog ANG-2
Polyclonal Antibody for Dog ANG-2
Polyclonal Antibody for Dog ANG-2
Polyclonal Antibody for Dog ANG-2
Monoclonal Antibody for Dog ANG-2
Monoclonal Antibody for Dog ANG-2
Monoclonal Antibody for Dog ANG-2
Monoclonal Antibody for Dog ANG-2
Monoclonal Antibody for Dog ANG-2
Monoclonal Antibody for Dog ANG-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Gene expressions of canine angiopoietin-1 and -2 in normal tissues and spontaneous tumours."
Kato Y.
,
Asano K.
,
Mizutani I.
,
Konno T.
,
Sasaki Y.
,
Kutara K.
,
Teshima K.
,
Edamura K.
,
Kano R.
,
Suzuki K.
,
Shibuya H.
,
Sato T.
,
Hasegawa A.
,
Tanaka S.
Res. Vet. Sci.81:280-286(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]