Protein name:
Angiopoietin-2 (ANG-2) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Function:
Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Subcellular Location:
Secreted
Protein Attributes:
50:
MWQIVFFTLS | CDLVLAAAYN | NFRKSMDSIG | KKQYQVQHGS | CSYTFLLPEM |
100:
DNCRSSSSPY | VSNAVQRDAP | LEYDDSVQRL | QVLENIMENN | TQWLMKLENY |
150:
IQDNMKKEMV | EIQQNAVQNQ | TAVMIEIGTN | LLNQTAEQTR | KLTDVEAQVL |
200:
NQTTRLELQL | LEHSLSTNKL | EKQILDQTSE | INKLQDKNSF | LEKKVLAMED |
250:
KHIIQLQSIK | EEKDQLQVLV | SKQNSIIEEL | EKKIVTATVN | NSVLQKQQHD |
300:
LMETVNNLLT | MMSTSNSAKD | PTVAKEEQIS | FRDCAEVFKS | GHTTNGIYTL |
350:
TFPNSTEEIK | AYCDMEAGGG | GWTIIQRRED | GSVDFQRTWK | EYKVGFGNPS |
400:
GEYWLGNEFV | SQLTNQQRYV | LKIHLKDWEG | NEAYSLYEHF | YLSSEELNYR |
450:
IHLKGLTGTA | GKISSISQPG | NDFSTKDGDN | DKCICKCSQM | LTGGWWFDAC |
496:
GPSNLNGMYY | PQRQNTNKFN | GIKWYYWKGS | GYSLKATTMM | IRPADF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
Dog
ELISA Kit for Human ANG-2
ELISA Kit for Human ANG-2
ELISA Kit for Human ANG-2
ELISA Kit for Human ANG-2
ELISA Kit for Human ANG-2
ELISA Kit for Human ANG-2
Polyclonal Antibody for Human ANG-2
Polyclonal Antibody for Human ANG-2
Polyclonal Antibody for Human ANG-2
Polyclonal Antibody for Human ANG-2
Polyclonal Antibody for Human ANG-2
Polyclonal Antibody for Human ANG-2
Monoclonal Antibody for Human ANG-2
Monoclonal Antibody for Human ANG-2
Monoclonal Antibody for Human ANG-2
Monoclonal Antibody for Human ANG-2
Monoclonal Antibody for Human ANG-2
Monoclonal Antibody for Human ANG-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Yesildal F, Koc E, Tas A, et al.
References
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"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis."
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH TEK/TIE2;FUNCTION
tissue :
Lung .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue :
Umbilical vein endothelial cell .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Substantia nigra .
5.
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[
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Colon .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TEK/TIE2
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1;INTERACTION WITH TEK/TIE2
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TEK/TIE2
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 281-496;DISULFIDE BONDS;CALCIUM-BINDING SITES
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.7 ANGSTROMS) OF 281-495 IN COMPLEX WITH TEK;DISULFIDE BONDS;CALCIUM-BINDING SITES