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Index > Protein center > Prmt5(Gene name) > Mouse
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  • Prmt5 (Gene name),
  • Protein arginine N-methyltransferase 5 (Protein name ),  ANM5_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Prmt5(Jbp1;Skb1);
    Protein name:
    Protein arginine N-methyltransferase 5;
    Alternative:
    Jak-binding protein 1;2.1.1.125;Histone-arginine N-methyltransferase PRMT5);Shk1 kinase-binding protein 1 homolog(SKB1 homolog);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms, at least, homodimers and homotetramers. Component of the methylosome, a 20S complex containing at least pICLn, PRMT5/SKB1 and MEP50. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Also interacts with Sm proteins, JAK2 and SSTR1. Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Interacts with LSM11, PRMT7 and SNRPD3. Interacts with COPR5; promoting its recruitment on histone H4 (By similarity). Interacts with PRDM1. Interacts with RPS10.
    Function:
    Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    637
    Sequence:
    50:
    MAAMAVGGAG | GSRVSSGRDL | NCVPEIADTL | GAVAKQGFDF | LCMPVFHPRF | 
    100:
    KREFIQEPAK | NRPGPQTRSD | LLLSGRDWNT | LIVGKLSPWI | HPDSKVEKIR | 
    150:
    RNSEAAMLQE | LNFGAYLGLP | AFLLPLNQED | NTNLARVLTN | HIHTGHHSSM | 
    200:
    FWMRVPLVAP | EDLRDDVIAN | APTTHTEEYS | GEEKTWMWWH | NFRTLCDYSK | 
    250:
    RIAVALEIGA | DLPSNHVIDR | WLGEPIKAAI | LPTSIFLTNK | KGFPVLSKVQ | 
    300:
    QRLIFRLLKL | EVQFIITGTN | HHSEKEFCSY | LQYLEYLSQN | RPPPNAYELF | 
    350:
    AKGYEDYLQS | PLQPLMDNLE | SQTYEVFEKD | PIKYSQYQQA | IYKCLLDRVP | 
    400:
    EEEKETNVQV | LMVLGAGRGP | LVNASLRAAK | QAERRIRLYA | VEKNPNAVVT | 
    450:
    LENWQFEEWG | SQVTVVSSDM | REWVAPEKAD | IIVSELLGSF | ADNELSPECL | 
    500:
    DGAQHFLKDD | GVSIPGEYTS | FLAPISSSKL | YNEVRACREK | DRDPEAQFEM | 
    550:
    PYVVRLHNFH | QLSAPKPCFT | FSHPNRDPMI | DNNRYCTLEF | PVEVNTVLHG | 
    600:
    FAGYFETVLY | RDITLSIRPE | THSPGMFSWF | PIFFPIKQPI | TVHEGQNICV | 
    637:
    RFWRCSNSKK | VWYEWAVTAP | VCSSIHNPTG | RSYTIGL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Protein arginine N-methyltransferase 5
    ELISA Kit for Mouse Protein arginine N-methyltransferase 5
    ELISA Kit for Mouse Protein arginine N-methyltransferase 5
    CLIA Kit for Mouse Protein arginine N-methyltransferase 5
    CLIA Kit for Mouse Protein arginine N-methyltransferase 5
    CLIA Kit for Mouse Protein arginine N-methyltransferase 5
    Polyclonal Antibody for Mouse Protein arginine N-methyltransferase 5
    Polyclonal Antibody for Mouse Protein arginine N-methyltransferase 5
    Polyclonal Antibody for Mouse Protein arginine N-methyltransferase 5
    Monoclonal Antibody for Mouse Protein arginine N-methyltransferase 5
    Monoclonal Antibody for Mouse Protein arginine N-methyltransferase 5
    Monoclonal Antibody for Mouse Protein arginine N-methyltransferase 5
    Protein for Mouse Protein arginine N-methyltransferase 5
    Protein for Mouse Protein arginine N-methyltransferase 5
    Protein for Mouse Protein arginine N-methyltransferase 5

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    Precision
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Skin.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    3. 3.
      "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity."
      Pollack B.P. , Kotenko S.V. , He W. , Izotova L.S. , Barnoski B.L. , Pestka S.
      J. Biol. Chem.274:31531-31542(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-637
    4. 4.
      "Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes."
      Pal S. , Vishwanath S.N. , Erdjument-Bromage H. , Tempst P. , Sif S.
      Mol. Cell. Biol.24:9630-9645(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN METHYLATION OF HISTONE H3
    5. 5.
      "Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells."
      Ancelin K. , Lange U.C. , Hajkova P. , Schneider R. , Bannister A.J. , Kouzarides T. , Surani M.A.
      Nat. Cell Biol.8:623-630(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRDM1
    6. 6.
      "Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members."
      Vagin V.V. , Wohlschlegel J. , Qu J. , Jonsson Z. , Huang X. , Chuma S. , Girard A. , Sachidanandam R. , Hannon G.J. , Aravin A.A.
      Genes Dev.23:1749-1762(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN METHYLATION OF PIWI PROTEINS
    7. 7.
      "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases."
      van Dijk T.B. , Gillemans N. , Stein C. , Fanis P. , Demmers J. , van de Corput M. , Essers J. , Grosveld F. , Bauer U.M. , Philipsen S.
      Mol. Cell. Biol.30:260-272(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CHTOP
    8. 8.
      "Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF."
      Andreu-Perez P. , Esteve-Puig R. , de Torre-Minguela C. , Lopez-Fauqued M. , Bech-Serra J.J. , Tenbaum S. , Garcia-Trevijano E.R. , Canals F. , Merlino G. , Avila M.A. , Recio J.A.
      Sci. Signal.4:RA58-RA58(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE REGULATION OF MAPK1/MAPK3 SIGNALING PATHWAY;RAF1 METHYLATION
    9. 9.
      "Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."
      Fanis P. , Gillemans N. , Aghajanirefah A. , Pourfarzad F. , Demmers J. , Esteghamat F. , Vadlamudi R.K. , Grosveld F. , Philipsen S. , van Dijk T.B.
      Mol. Cell. Proteomics11:1263-1273(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CHTOP;SUBCELLULAR LOCATION
    10. 10.
      "The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation."
      Paul C. , Sardet C. , Fabbrizio E.
      Cell Death Differ.19:900-908(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPRS;IDENTIFICATION IN A COMPLEX WITH PRMT5; RUNX1 AND CBFB
    11. 11.
      "Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene."
      Na J. , Lee K. , Kim H.G. , Shin J.Y. , Na W. , Jeong H. , Lee J.W. , Cho S. , Kim W.S. , Ju B.G.
      PLoS ONE7:E48152-E48152(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CRY1
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