Gene name:
PRMT7 (KIAA1933) ;
Protein name:
Protein arginine N-methyltransferase 7 ;
Alternative:
2.1.1.126;[Myelin basic protein]-arginine N-methyltransferase PRMT7 ) ;2.1.1.125;Histone-arginine N-methyltransferase PRMT7 ) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.
Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
Subcellular Location:
Cytoplasm
cytosol
Nucleus
Protein Attributes:
50:
MKIFCSRANP | TTGSVEWLEE | DEHYDYHQEI | ARSSYADMLH | DKDRNVKYYQ |
100:
GIRAAVSRVK | DRGQKALVLD | IGTGTGLLSM | MAVTAGADFC | YAIEVFKPMA |
150:
DAAVKIVEKN | GFSDKIKVIN | KHSTEVTVGP | EGDMPCRANI | LVTELFDTEL |
200:
IGEGALPSYE | HAHRHLVEEN | CEAVPHRATV | YAQLVESGRM | WSWNKLFPIH |
250:
VQTSLGEQVI | VPPVDVESCP | GAPSVCDIQL | NQVSPADFTV | LSDVLPMFSI |
300:
DFSKQVSSSA | ACHSRRFEPL | TSGRAQVVLS | WWDIEMDPEG | KIKCTMAPFW |
350:
AHSDPEEMQW | RDHWMQCVYF | LPQEEPVVQG | SALYLVAHHD | DYCVWYSLQR |
400:
TSPEKNERVR | QMRPVCDCQA | HLLWNRPRFG | EINDQDRTDR | YVQALRTVLK |
450:
PDSVCLCVSD | GSLLSVLAHH | LGVEQVFTVE | SSAASHKLLR | KIFKANHLED |
500:
KINIIEKRPE | LLTNEDLQGR | KVSLLLGEPF | FTTSLLPWHN | LYFWYVRTAV |
550:
DQHLGPGAMV | MPQAASLHAV | VVEFRDLWRI | RSPCGDCEGF | DVHIMDDMIK |
600:
RALDFRESRE | AEPHPLWEYP | CRSLSEPWQI | LTFDFQQPVP | LQPLCAEGTV |
650:
ELRRPGQSHA | AVLWMEYHLT | PECTLSTGLL | EPADPEGGCC | WNPHCKQAVY |
692:
FFSPAPDPRA | LLGGPRTVSY | AVEFHPDTGD | IIMEFRHADT | PD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Chicken
Human
Bovine
Rat
ELISA Kit for Human Protein arginine N-methyltransferase 7
ELISA Kit for Human Protein arginine N-methyltransferase 7
ELISA Kit for Human Protein arginine N-methyltransferase 7
ELISA Kit for Human Protein arginine N-methyltransferase 7
ELISA Kit for Human Protein arginine N-methyltransferase 7
CLIA Kit for Human Protein arginine N-methyltransferase 7
CLIA Kit for Human Protein arginine N-methyltransferase 7
CLIA Kit for Human Protein arginine N-methyltransferase 7
CLIA Kit for Human Protein arginine N-methyltransferase 7
CLIA Kit for Human Protein arginine N-methyltransferase 7
Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
Protein for Human Protein arginine N-methyltransferase 7
Protein for Human Protein arginine N-methyltransferase 7
Protein for Human Protein arginine N-methyltransferase 7
Protein for Human Protein arginine N-methyltransferase 7
Protein for Human Protein arginine N-methyltransferase 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
tissue :
Brain .
tissue :
Spleen .
tissue :
Uterus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-692 (ISOFORM 2)
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PRMT5 AND SNRPD3
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INCREASED SENSITIVITY TO CAMPTOTHECIN
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POSSIBLE INVOLVEMENT IN ETOPOSIDE-INDUCED CYTOTOXICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
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Kim D.S.
,
De Juan-Pardo E.
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Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]