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Index > Protein center > PRMT7(Gene name) > Human
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  • PRMT7 (Gene name),
  • Protein arginine N-methyltransferase 7 (Protein name ),  ANM7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PRMT7(KIAA1933);
    Protein name:
    Protein arginine N-methyltransferase 7;
    Alternative:
    2.1.1.126;[Myelin basic protein]-arginine N-methyltransferase PRMT7);2.1.1.125;Histone-arginine N-methyltransferase PRMT7);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.
    Function:
    Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
    Subcellular Location:
    Cytoplasm cytosol Nucleus
    Protein Attributes:
    Sequence length:
    692
    Sequence:
    50:
    MKIFCSRANP | TTGSVEWLEE | DEHYDYHQEI | ARSSYADMLH | DKDRNVKYYQ | 
    100:
    GIRAAVSRVK | DRGQKALVLD | IGTGTGLLSM | MAVTAGADFC | YAIEVFKPMA | 
    150:
    DAAVKIVEKN | GFSDKIKVIN | KHSTEVTVGP | EGDMPCRANI | LVTELFDTEL | 
    200:
    IGEGALPSYE | HAHRHLVEEN | CEAVPHRATV | YAQLVESGRM | WSWNKLFPIH | 
    250:
    VQTSLGEQVI | VPPVDVESCP | GAPSVCDIQL | NQVSPADFTV | LSDVLPMFSI | 
    300:
    DFSKQVSSSA | ACHSRRFEPL | TSGRAQVVLS | WWDIEMDPEG | KIKCTMAPFW | 
    350:
    AHSDPEEMQW | RDHWMQCVYF | LPQEEPVVQG | SALYLVAHHD | DYCVWYSLQR | 
    400:
    TSPEKNERVR | QMRPVCDCQA | HLLWNRPRFG | EINDQDRTDR | YVQALRTVLK | 
    450:
    PDSVCLCVSD | GSLLSVLAHH | LGVEQVFTVE | SSAASHKLLR | KIFKANHLED | 
    500:
    KINIIEKRPE | LLTNEDLQGR | KVSLLLGEPF | FTTSLLPWHN | LYFWYVRTAV | 
    550:
    DQHLGPGAMV | MPQAASLHAV | VVEFRDLWRI | RSPCGDCEGF | DVHIMDDMIK | 
    600:
    RALDFRESRE | AEPHPLWEYP | CRSLSEPWQI | LTFDFQQPVP | LQPLCAEGTV | 
    650:
    ELRRPGQSHA | AVLWMEYHLT | PECTLSTGLL | EPADPEGGCC | WNPHCKQAVY | 
    692:
    FFSPAPDPRA | LLGGPRTVSY | AVEFHPDTGD | IIMEFRHADT | PD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    SMR:
    MIM:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein arginine N-methyltransferase 7
    ELISA Kit for Human Protein arginine N-methyltransferase 7
    ELISA Kit for Human Protein arginine N-methyltransferase 7
    ELISA Kit for Human Protein arginine N-methyltransferase 7
    ELISA Kit for Human Protein arginine N-methyltransferase 7
    CLIA Kit for Human Protein arginine N-methyltransferase 7
    CLIA Kit for Human Protein arginine N-methyltransferase 7
    CLIA Kit for Human Protein arginine N-methyltransferase 7
    CLIA Kit for Human Protein arginine N-methyltransferase 7
    CLIA Kit for Human Protein arginine N-methyltransferase 7
    Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
    Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
    Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
    Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
    Polyclonal Antibody for Human Protein arginine N-methyltransferase 7
    Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
    Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
    Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
    Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
    Monoclonal Antibody for Human Protein arginine N-methyltransferase 7
    Protein for Human Protein arginine N-methyltransferase 7
    Protein for Human Protein arginine N-methyltransferase 7
    Protein for Human Protein arginine N-methyltransferase 7
    Protein for Human Protein arginine N-methyltransferase 7
    Protein for Human Protein arginine N-methyltransferase 7

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    Precision
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
      tissue: Brain.
      tissue: Spleen.
      tissue: Uterus.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    3. 3.
      "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T. , Kikuno R. , Ohara O.
      DNA Res.8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-692 (ISOFORM 2)
      tissue: Brain.
    4. 4.
      "PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity."
      Miranda T.B. , Miranda M. , Frankel A. , Clarke S.
      J. Biol. Chem.279:22902-22907(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine."
      Lee J.-H. , Cook J.R. , Yang Z.-H. , Mirochnitchenko O. , Gunderson S.I. , Felix A.M. , Herth N. , Hoffmann R. , Pestka S.
      J. Biol. Chem.280:3656-3664(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    6. 6.
      "Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins."
      Gonsalvez G.B. , Tian L. , Ospina J.K. , Boisvert F.-M. , Lamond A.I. , Matera A.G.
      J. Cell Biol.178:733-740(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PRMT5 AND SNRPD3
    7. 7.
      "Protein arginine (N)-methyl transferase 7 (PRMT7) as a potential target for the sensitization of tumor cells to camptothecins."
      Verbiest V. , Montaudon D. , Tautu M.T. , Moukarzel J. , Portail J.-P. , Markovits J. , Robert J. , Ichas F. , Pourquier P.
      FEBS Lett.582:1483-1489(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INCREASED SENSITIVITY TO CAMPTOTHECIN
    8. 8.
      "Identification of genomic regions contributing to etoposide-induced cytotoxicity."
      Bleibel W.K. , Duan S. , Huang R.S. , Kistner E.O. , Shukla S.J. , Wu X. , Badner J.A. , Dolan M.E.
      Hum. Genet.125:173-180(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN ETOPOSIDE-INDUCED CYTOTOXICITY
    9. 9.
      "Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry."
      Wang H. , Straubinger R.M. , Aletta J.M. , Cao J. , Duan X. , Yu H. , Qu J.
      J. Am. Soc. Mass Spectrom.20:507-519(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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