Protein name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A;Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) ;
Alternative:
Phosphatase interactor targeting protein hnRNP K (PITK) ;Ankyrin repeat domain-containing protein 28 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.
Function:
Putative regulatory subunit of protein phospatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.
Subcellular Location:
Nucleus
nucleoplasm
Seems to be excluded from nucleoli.
Protein Attributes:
50:
MAFLKLRDQP | SLVQAIFNGD | PDEVRALIFK | KEDVNFQDNE | KRTPLHAAAY |
100:
LGDAEIIELL | ILSGARVNAK | DSKWLTPLHR | AVASCSEEAV | QILLKHSADV |
150:
NARDKNWQTP | LHIAAANKAV | KCAESLVPLL | SNVNVSDRAG | RTALHHAAFS |
200:
GHGEMVKLLL | SRGANINAFD | KKDRRAIHWA | AYMGHIEVVK | LLVSHGAEVT |
250:
CKDKKSYTPL | HAAASSGMIS | VVKYLLDLGV | DMNEPNAYGN | TPLHVACYNG |
300:
QDVVVNELID | CGANVNQKNE | KGFTPLHFAA | ASTHGALCLE | LLVGNGADVN |
350:
MKSKDGKTPL | HMTALHGRFS | RSQTIIQSGA | VIDCEDKNGN | TPLHIAARYG |
400:
HELLINTLIT | SGADTAKRGI | HGMFPLHLAA | LSGFSDCCRK | LLSSGFDIDT |
450:
PDDFGRTCLH | AAAAGGNLEC | LNLLLNTGAD | FNKKDKFGRS | PLHYAAANCN |
500:
YQCLFALVGS | GASVNDLDER | GCTPLHYAAT | SDTDGKCLEY | LLRNDANPGI |
550:
RDKQGYNAVH | YSAAYGHRLC | LQLIASETPL | DVLMETSGTD | MLSDSDNRAT |
600:
ISPLHLAAYH | GHHQALEVLV | QSLLDLDVRN | SSGRTPLDLA | AFKGHVECVD |
650:
VLINQGASIL | VKDYVLKRTP | IHAAATNGHS | ECLRLLIGNA | EPQNAVDIQD |
700:
GNGQTPLMLS | VLNGHTDCVY | SLLNKGANVD | AKDKWGRTAL | HRGAVTGHEE |
750:
CVDALLQHGA | KCLLRDSRGR | TPIHLSAACG | HIGVLGALLQ | SATSVDANPA |
800:
VVDNHGYTAL | HWACYNGHET | CVELLLEQDV | FQKIDGNAFS | PLHCAVINDN |
850:
EGAAEMLIDS | LGASIVNATD | SKGRTPLHAA | AFTDHVECLQ | LLLSQNAQVN |
900:
SADSTGKTPL | MMAAENGQTN | TVEMLVSSAS | ADLTLQDKSK | NTALHLACGK |
950:
GHETSALLIL | EKITDRNLIN | ATNAALQTPL | HVAARNGLTM | VVQELLGKGA |
1000:
SVLAVDENGY | TPALACAPNK | DVADCLALIL | ATMMPVSSSS | PLTSLTFNAI |
1050:
NRYTNTSKTV | SFEALPIMRN | EASSYCSFNN | IGGEQEYLYT | DVDELNDSDS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse PP6-ARS-A
ELISA Kit for Mouse PP6-ARS-A
CLIA Kit for Mouse PP6-ARS-A
CLIA Kit for Mouse PP6-ARS-A
Polyclonal Antibody for Mouse PP6-ARS-A
Polyclonal Antibody for Mouse PP6-ARS-A
Monoclonal Antibody for Mouse PP6-ARS-A
Monoclonal Antibody for Mouse PP6-ARS-A
Protein for Mouse PP6-ARS-A
Protein for Mouse PP6-ARS-A
R&D Technical Data
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Precision
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
tissue :
Olfactory epithelium .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY