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Index > Protein center > ANKS1B(Gene name) > Human
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  • ANKS1B (Gene name),
  • Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Protein name ),  ANS1B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    ANKS1B;
    Protein name:
    Ankyrin repeat and sterile alpha motif domain-containing protein 1B;
    Alternative:
    E2A-PBX1-associated protein(EB-1);Amyloid-beta protein intracellular domain-associated protein 1(AIDA-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Isoform 3 interacts with DLG4 (By similarity). Interacts with EPHA8. Isoform 2 interacts with COIL. Isoform 4 interacts with APP and EPHA8. Isoform 6 interacts with EPHA8.
    Function:
    Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
    Subcellular Location:
    Isoform 6 Nucleus
    Protein Attributes:
    Sequence length:
    1248
    Sequence:
    50:
    MGKDQELLEA | ARTGNVALVE | KLLSGRKGGI | LGGGSGPLPL | SNLLSIWRGP | 
    100:
    NVNCTDSSGY | TALHHAALNG | HKDIVLKLLQ | YEASTNVADN | KGYFPIHLAA | 
    150:
    WKGDVEIVKI | LIHHGPSHSR | VNEQNNENET | ALHCAAQYGH | SEVVAVLLEE | 
    200:
    LTDPTIRNSK | LETPLDLAAL | YGRLRVVKMI | ISAHPNLMSC | NTRKHTPLHL | 
    250:
    AARNGHKAVV | QVLLEAGMDV | SCQTEKGSAL | HEAALFGKVD | VVRVLLETGI | 
    300:
    DANIKDSLGR | TVLDILKEHP | SQKSLQIATL | LQEYLEGVGR | STVLEEPVQE | 
    350:
    DATQETHISS | PVESPSQKTK | SETVTGELSK | LLDEIKLCQE | KDYSFEDLCH | 
    400:
    TISDHYLDNL | SKISEEELGK | NGSQSVRTSS | TINLSPGEVE | EEDDDENTCG | 
    450:
    PSGLWEALTP | CNGCRNLGFP | MLAQESYPKK | RNYTMEIVPS | ASLDTFPSEN | 
    500:
    ENFLCDLMDT | AVTKKPCSLE | IARAPSPRTD | NASEVAVTTP | GTSNHRNSST | 
    550:
    GPTPDCSPPS | PDTALKNIVK | VIRPQPKQRT | SIVSSLDFHR | MNHNQEYFEI | 
    600:
    NTSTGCTSFT | ASPPASPPTS | SVGTTEVKNE | GTNHTDDLSR | QDDNDPPKEY | 
    650:
    DPGQFAGLLH | GSSPACESPE | NPFHLYGKRE | QCEKGQDEVS | LANSPLPFKQ | 
    700:
    SPIENNSEPL | VKKIKPKVVS | RTIFHKKSNQ | LENHTIVGTR | STRSGSRNGD | 
    750:
    QWVMNAGGFV | ERACTLGRIR | SLPKALIDMH | LSKSVSKSDS | DLIAYPSNEK | 
    800:
    TSRVNWSESS | TAEHSSKGNS | ERTPSFTSEW | EEIDKIMSSI | DVGINNELKE | 
    850:
    MNGETTRPRC | PVQTVGQWLE | SIGLPQYENH | LMANGFDNVQ | FMGSNVMEDQ | 
    900:
    DLLEIGILNS | GHRQRILQAI | QLLPKMRPIG | HDGYHPTSVA | EWLDSIELGD | 
    950:
    YTKAFLINGY | TSMDLLKKIW | EVELINVLKI | NLIGHRKRIL | ASLGDRLHDD | 
    1000:
    PPQKPPRSIT | LREPSGNHTP | PQLSPSLSQS | TYTTGGSLDV | PHIIMQGDAR | 
    1050:
    RRRNENYFDD | IPRSKLERQM | AQTGDWGEPS | ITLRPPNEAT | ASTPVQYWQH | 
    1100:
    HPEKLIFQSC | DYKAFYLGSM | LIKELRGTES | TQDACAKMRA | NCQKSTEQMK | 
    1150:
    KVPTIILSVS | YKGVKFIDAT | NKNIIAEHEI | RNISCAAQDP | EDLSTFAYIT | 
    1200:
    KDLKSNHHYC | HVFTAFDVNL | AYEIILTLGQ | AFEVAYQLAL | QARKGGHSST | 
    1248:
    LPESFENKPS | KPIPKPRVSI | RKSVDLLHAS | HTGQEPSERH | TEEALRKF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    Pfam:
    MIM:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    ELISA Kit for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    ELISA Kit for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    CLIA Kit for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    CLIA Kit for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    CLIA Kit for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Polyclonal Antibody for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Polyclonal Antibody for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Polyclonal Antibody for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Monoclonal Antibody for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Monoclonal Antibody for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Monoclonal Antibody for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Protein for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Protein for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B
    Protein for Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing."
      Ghersi E. , Vito P. , Lopez P. , Abdallah M. , D'Adamio L.
      J. Alzheimers Dis.6:67-78(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6 AND 4);INTERACTION WITH APP;SUBCELLULAR LOCATION
      tissue: Fetal brain.
    2. 2.
      "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin."
      Xu H. , Hebert M.D.
      BMC Cell Biol.6:23-23(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH COIL;SUBCELLULAR LOCATION
      tissue: Brain.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
      tissue: Adrenal gland.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 9 AND 10)
      tissue: Amygdala.
      tissue: Brain.
    5. 5.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 5; 7 AND 8)
      tissue: Brain.
      tissue: Hippocampus.
    7. 7.
      "EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1."
      Fu X. , McGrath S. , Pasillas M. , Nakazawa S. , Kamps M.P.
      Oncogene18:4920-4929(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-1248 (ISOFORM 1);INDUCTION;TISSUE SPECIFICITY
    8. 8.
      "Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner."
      Ghersi E. , Noviello C. , D'Adamio L.
      J. Biol. Chem.279:49105-49112(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 425-1192 (ISOFORM 1);FUNCTION;INTERACTION WITH APP;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line."
      Casagrande G. , te Kronnie G. , Basso G.
      Haematologica91:765-771(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    10. 10.
      "Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function."
      Shin J. , Gu C. , Park E. , Park S.
      Mol. Cell. Biol.27:8113-8126(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHA8
    11. 11.
      "A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import."
      Kurabi A. , Brener S. , Mobli M. , Kwan J.J. , Donaldson L.W.
      J. Mol. Biol.392:1168-1177(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 813-947;SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNAL
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