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Index > Protein center > AOC3(Gene name) > Human
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  • AOC3 (Gene name),
  • Membrane primary amine oxidase (Protein name ),  AOC3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    AOC3(VAP1);
    Protein name:
    Membrane primary amine oxidase;
    Alternative:
    HPAO;Copper amine oxidase;Vascular adhesion protein 1(VAP-1);Semicarbazide-sensitive amine oxidase(SSAO);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Forms heterodimer with AOC2.
    Function:
    Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    763
    Sequence:
    50:
    MNQKTILVLL | ILAVITIFAL | VCVLLVGRGG | DGGEPSQLPH | CPSVSPSAQP | 
    100:
    WTHPGQSQLF | ADLSREELTA | VMRFLTQRLG | PGLVDAAQAR | PSDNCVFSVE | 
    150:
    LQLPPKAAAL | AHLDRGSPPP | AREALAIVFF | GRQPQPNVSE | LVVGPLPHPS | 
    200:
    YMRDVTVERH | GGPLPYHRRP | VLFQEYLDID | QMIFNRELPQ | ASGLLHHCCF | 
    250:
    YKHRGRNLVT | MTTAPRGLQS | GDRATWFGLY | YNISGAGFFL | HHVGLELLVN | 
    300:
    HKALDPARWT | IQKVFYQGRY | YDSLAQLEAQ | FEAGLVNVVL | IPDNGTGGSW | 
    350:
    SLKSPVPPGP | APPLQFYPQG | PRFSVQGSRV | ASSLWTFSFG | LGAFSGPRIF | 
    400:
    DVRFQGERLV | YEISLQEALA | IYGGNSPAAM | TTRYVDGGFG | MGKYTTPLTR | 
    450:
    GVDCPYLATY | VDWHFLLESQ | APKTIRDAFC | VFEQNQGLPL | RRHHSDLYSH | 
    500:
    YFGGLAETVL | VVRSMSTLLN | YDYVWDTVFH | PSGAIEIRFY | ATGYISSAFL | 
    550:
    FGATGKYGNQ | VSEHTLGTVH | THSAHFKVDL | DVAGLENWVW | AEDMVFVPMA | 
    600:
    VPWSPEHQLQ | RLQVTRKLLE | MEEQAAFLVG | SATPRYLYLA | SNHSNKWGHP | 
    650:
    RGYRIQMLSF | AGEPLPQNSS | MARGFSWERY | QLAVTQRKEE | EPSSSSVFNQ | 
    700:
    NDPWAPTVDF | SDFINNETIA | GKDLVAWVTA | GFLHIPHAED | IPNTVTVGNG | 
    750:
    VGFFLRPYNF | FDEDPSFYSA | DSIYFRGDQD | AGACEVNPLA | CLPQAAACAP | 
    763:
    DLPAFSHGGF | SHN
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    Pfam:
    MIM:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Membrane primary amine oxidase
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    ELISA Kit for Human Membrane primary amine oxidase
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    ELISA Kit for Human Membrane primary amine oxidase
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    ELISA Kit for Human Membrane primary amine oxidase
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    CLIA Kit for Human Membrane primary amine oxidase
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    CLIA Kit for Human Membrane primary amine oxidase
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    U1083m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Membrane primary amine oxidase
    Cat.:
    U1083h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Membrane primary amine oxidase
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    Packing:
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    Polyclonal Antibody for Human Membrane primary amine oxidase
    Polyclonal Antibody for Human Membrane primary amine oxidase
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    P1083Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Membrane primary amine oxidase
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    Polyclonal Antibody for Human Membrane primary amine oxidase
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    P1083Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Membrane primary amine oxidase
    Monoclonal Antibody for Human Membrane primary amine oxidase
    Monoclonal Antibody for Human Membrane primary amine oxidase
    Monoclonal Antibody for Human Membrane primary amine oxidase
    Protein for Human Membrane primary amine oxidase
    Protein for Human Membrane primary amine oxidase
    Protein for Human Membrane primary amine oxidase
    Protein for Human Membrane primary amine oxidase

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    References
    1. 1.
      "Cloning and sequencing of a copper-containing, topaquinone-containing monoamine oxidase from human placenta."
      Zhang X. , McIntire W.S.
      Gene179:279-286(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    2. 2.
      "Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule."
      Smith D.J. , Salmi M. , Bono P. , Hellman J. , Leu T. , Jalkanen S.
      J. Exp. Med.188:17-27(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;FUNCTION;SELF-ASSOCIATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Lung.
    3. 3.
      "Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina."
      Zhang Q. , Mashima Y. , Noda S. , Imamura Y. , Kudoh J. , Shimizu N. , Nishiyama T. , Umeda S. , Oguchi Y. , Tanaka Y. , Iwata T.
      Gene318:45-53(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Functional modulation of vascular adhesion protein-1 by a novel splice variant."
      Kaitaniemi S. , Gron K. , Elovaara H. , Salmi M. , Jalkanen S. , Elima K.
      PLoS ONE8:E54151-E54151(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBUNIT;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Placenta.
    6. 6.
      NIEHS SNPs program
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-5; TYR-167; THR-371; SER-408; HIS-426; TRP-441; THR-582; SER-700 AND VAL-749
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: PNS.
    8. 9.
      "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
      Aboulaich N. , Vainonen J.P. , Stralfors P. , Vener A.V.
      Biochem. J.383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 79-90 AND 123-132
      tissue: Adipocyte.
    9. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-592; ASN-618 AND ASN-666
      tissue: Plasma.
    10. 11.
      "Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes."
      Bour S. , Daviaud D. , Gres S. , Lefort C. , Prevot D. , Zorzano A. , Wabitsch M. , Saulnier-Blache J.-S. , Valet P. , Carpene C.
      Biochimie89:916-925(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION
    11. 12.
      "The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase."
      Kaitaniemi S. , Elovaara H. , Groen K. , Kidron H. , Liukkonen J. , Salminen T. , Salmi M. , Jalkanen S. , Elima K.
      Cell. Mol. Life Sci.66:2743-2757(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;MUTAGENESIS OF MET-211; TYR-394 AND LEU-469
    12. 13.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-137; ASN-294; ASN-592; ASN-618 AND ASN-666
      tissue: Liver.
    13. 14.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-592
    14. 15.
      "Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications."
      Airenne T.T. , Nymalm Y. , Kidron H. , Smith D.J. , Pihlavisto M. , Salmi M. , Jalkanen S. , Johnson M.S. , Salminen T.A.
      Protein Sci.14:1964-1974(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) IN COMPLEX WITH COPPER AND CALCIUM IONS;DISULFIDE BONDS;TOPAQUINONE AT TYR-471;GLYCOSYLATION AT ASN-137; THR-212; ASN-232; ASN-294; ASN-592; ASN-618 AND ASN-666
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