Aox3 ELISA Kit for Mouse(Mus musculus) | EIAab.comAox3 ELISA Kit for Mouse(Mus musculus)

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Aox3 (Gene name),

Aldehyde oxidase 3 (Protein name ), AOXC_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aox3(Aoh1);

Protein name:

Aldehyde oxidase 3;

Alternative:

1.17.3.-;Azaheterocycle hydroxylase 3);Aldehyde oxidase homolog 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer.

Function:

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1335

Sequence:

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1335:

PATAEVIRMA | CEDQFTNLVP | QTDSKCCKPW | SIPVA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01315

UniGene:

Mm.20108

KEGG:

mmu:71724

SMR:

G3X982

Uniprot:

G3X982

FOR

ELISA Kit for Mouse Aldehyde oxidase 3

CLIA Kit for Mouse Aldehyde oxidase 3

Polyclonal Antibody for Mouse Aldehyde oxidase 3

Monoclonal Antibody for Mouse Aldehyde oxidase 3

Protein for Mouse Aldehyde oxidase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1."
Terao M. , Kurosaki M. , Marini M. , Vanoni M.A. , Saltini G. , Bonetto V. , Bastone A. , Federico C. , Saccone S. , Fanelli R. , Salmona M. , Garattini E.
J. Biol. Chem.276:46347-46363(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION AS OXIDASE;ENZYME REGULATION;KINETIC PARAMETERS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: 129/Sv.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa."
Kurosaki M. , Terao M. , Barzago M.M. , Bastone A. , Bernardinello D. , Salmona M. , Garattini E.
J. Biol. Chem.279:50482-50498(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
strain: CD-1.
tissue: Olfactory epithelium.
6.

"Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse."
Terao M. , Kurosaki M. , Barzago M.M. , Fratelli M. , Bagnati R. , Bastone A. , Giudice C. , Scanziani E. , Mancuso A. , Tiveron C. , Garattini E.
Mol. Cell. Biol.29:357-377(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION BY TESTOSTERONE
7.

"Characterization and crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression."
Mahro M. , Coelho C. , Trincao J. , Rodrigues D. , Terao M. , Garattini E. , Saggu M. , Lendzian F. , Hildebrandt P. , Romao M.J. , Leimkuhler S.
Drug Metab. Dispos.39:1939-1945(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CRYSTALLIZATION;FUNCTION AS OXIDASE;SUBSTRATE SPECIFICITY;KINETIC PARAMETERS;COFACTOR;HOMODIMER
8.

"Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression."
Kurosaki M. , Bolis M. , Fratelli M. , Barzago M.M. , Pattini L. , Perretta G. , Terao M. , Garattini E.
Cell. Mol. Life Sci.70:1807-1830(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF PARALOGS
9.

"The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity."
Coelho C. , Mahro M. , Trincao J. , Carvalho A.T. , Ramos M.J. , Terao M. , Garattini E. , Leimkuhler S. , Romao M.J.
J. Biol. Chem.287:40690-40702(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS) IN COMPLEX WITH FE-S CLUSTERS; FAD AND MO-MPT;FUNCTION AS OXIDASE;SUBSTRATE SPECIFICITY;COFACTOR;KINETIC PARAMETERS;HOMODIMER;ENZYME REGULATION;REACTION MECHANISM;ACTIVE SITE;MUTAGENESIS OF ALA-807; TYR-885; LYS-889 AND GLU-1266

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