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Index > Protein center > AP4S1(Gene name) > Human
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  • AP4S1 (Gene name),
  • AP-4 complex subunit sigma-1 (Protein name ),  AP4S1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    AP4S1;
    Protein name:
    AP-4 complex subunit sigma-1;
    Alternative:
    Adapter-related protein complex 4 subunit sigma-1;AP-4 adapter complex subunit sigma-1;Sigma-4-adaptin(Sigma4-adaptin);Sigma-1 subunit of AP-4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunitAP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).
    Function:
    Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
    Subcellular Location:
    Golgi apparatus trans-Golgi network Membrane coated pit Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.
    Protein Attributes:
    Sequence length:
    144
    Sequence:
    50:
    MIKFFLMVNK | QGQTRLSKYY | EHVDINKRTL | LETEVIKSCL | SRSNEQCSFI | 
    100:
    EYKDFKLIYR | QYAALFIVVG | VNDTENEMAI | YEFIHNFVEV | LDEYFSRVSE | 
    144:
    LDIMFNLDKV | HIILDEMVLN | GCIVETNRAR | ILAPLLILDK | MSES
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human AP-4 complex subunit sigma-1
    ELISA Kit for Human AP-4 complex subunit sigma-1
    ELISA Kit for Human AP-4 complex subunit sigma-1
    CLIA Kit for Human AP-4 complex subunit sigma-1
    CLIA Kit for Human AP-4 complex subunit sigma-1
    CLIA Kit for Human AP-4 complex subunit sigma-1
    Polyclonal Antibody for Human AP-4 complex subunit sigma-1
    Polyclonal Antibody for Human AP-4 complex subunit sigma-1
    Polyclonal Antibody for Human AP-4 complex subunit sigma-1
    Monoclonal Antibody for Human AP-4 complex subunit sigma-1
    Monoclonal Antibody for Human AP-4 complex subunit sigma-1
    Monoclonal Antibody for Human AP-4 complex subunit sigma-1
    Protein for Human AP-4 complex subunit sigma-1
    Protein for Human AP-4 complex subunit sigma-1
    Protein for Human AP-4 complex subunit sigma-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of a fourth adaptor-related protein complex."
      Hirst J. , Bright N.A. , Rous B. , Robinson M.S.
      Mol. Biol. Cell10:2787-2802(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    2. 2.
      "Identification and characterization of epsilon-adaptin that constitutes AP-4 clathrin adaptor-related complex."
      Takatsu H. , Sakurai M. , Shiba Y. , Yoshida Y. , Nakayama K.
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Full-length cDNA libraries and normalization."
      Li W.B. , Gruber C. , Jessee J. , Polayes D.
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
      tissue: B-cell.
      tissue: Fetal brain.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) System Donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Trachea.
    7. 7.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    10. 10.
      "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature."
      Abou Jamra R. , Philippe O. , Raas-Rothschild A. , Eck S.H. , Graf E. , Buchert R. , Borck G. , Ekici A. , Brockschmidt F.F. , Nothen M.M. , Munnich A. , Strom T.M. , Reis A. , Colleaux L.
      Am. J. Hum. Genet.88:788-795(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CPSQ6
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