APBA1 ELISA Kit for Human(Homo sapiens) | EIAab.comAPBA1 ELISA Kit for Human(Homo sapiens)

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APBA1 (Gene name),

Amyloid beta A4 precursor protein-binding family A member 1 (Protein name ), APBA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

APBA1(MINT1;X11);

Protein name:

Amyloid beta A4 precursor protein-binding family A member 1;

Alternative:

Neuron-specific X11 protein;Adapter protein X11alpha;Neuronal Munc18-1-interacting protein 1(Mint-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP).

Function:

Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

837

Sequence:

50:

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150:

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300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

837:

HEKIVHILSN | AVGEIHMKTM | PAAMYRLLTA | QEQPVYI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q02410

STRING:

9606.ENSP00000265381

String:

Q02410

MIM:

602414

Pfam:

PF00595

KEGG:

hsa:320

UniGene:

Hs.171939

Uniprot:

Q02410

FOR

ELISA Kit for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

E10313r

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96T

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ELISA Kit for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

E10313h

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96T

ELISA Kit for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

E10313m

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96T

CLIA Kit for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

U10313h

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96T

CLIA Kit for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

U10313m

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MSDS:

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Packing:

96T

CLIA Kit for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

U10313r

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96T

Polyclonal Antibody for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

P10313Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

P10313Rb-m

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Polyclonal Antibody for Human Amyloid beta A4 precursor protein-binding family A member 1

Cat.:

P10313Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Amyloid beta A4 precursor protein-binding family A member 1

Protein for Human Amyloid beta A4 precursor protein-binding family A member 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Mints, Munc18-interacting proteins in synaptic vesicle exocytosis."
Okamoto M. , Suedhof T.C.
J. Biol. Chem.272:31459-31464(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion."
Borg J.-P. , Yang Y. , De Taddeo-Borg M. , Margolis B. , Turner R.S.
J. Biol. Chem.273:14761-14766(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
3.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system."
Duclos F. , Koenig M. , Boschert U. , Sirugo G. , Hen R. , Mandel J.-L.
Proc. Natl. Acad. Sci. U.S.A.90:109-113(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-837 (ISOFORM 1)
tissue: Fetal brain.
5.

"The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein."
Borg J.-P. , Ooi J. , Levy E. , Margolis B.
Mol. Cell. Biol.16:6229-6241(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF PHE-608
6.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
7.

"An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."
Lau K.F. , Perkinton M.S. , Rodriguez L. , McLoughlin D.M. , Miller C.C.
NeuroReport21:761-766(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH FSBP
8.

"A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6."
Thyrock A. , Ossendorf E. , Stehling M. , Kail M. , Kurtz T. , Pohlentz G. , Waschbusch D. , Eggert S. , Formstecher E. , Muthing J. , Dreisewerd K. , Kins S. , Goud B. , Barnekow A.
PLoS ONE8:E64149-E64149(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 2);INTERACTION WITH APP; RAB6A AND RAB6B;SUBCELLULAR LOCATION (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
9.

"Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain."
Zhang Z. , Lee C.-H. , Mandiyan V. , Borg J.-P. , Margolis B. , Schlessinger J. , Kuriyan J.
EMBO J.16:6141-6150(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 452-617
10.

"Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 656-740

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