Amyloid beta A4 precursor protein-binding family B member 1 (Protein name
), APBB1_RAT from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
Apbb1(Fe65);
Protein name:
Amyloid beta A4 precursor protein-binding family B member 1;
Alternative:
Protein Fe65;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with SET. Found in a trimeric complex with HDAC1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3 (By similarity). Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts (via PID domain 2) with APP (with the intracellular domain of the beta-amyloid precursor protein). Interacts (via the WW domain) with histone H2AX (when phosphorylated on 'Tyr-142'). Interacts with MAPK8. Interacts (via the WW domain) with proline-rich regions of APBB1IP and ENAH. Interacts with TSHZ1 and TSHZ2 (By similarity). Interacts (via PID domain 1) with KAT5/TIP60. Interacts (via PID domain 2) with RASD1/DEXRAS1; impairs the trancription activation activity. Interacts (via PID domain 1) with TSHZ3 (via homeobox domain). Interacts (via WWW domain) with NEK6.
Function:
Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Subcellular Location:
Cell membrane
Cytoplasm
Nucleus
Cell projection
growth cone
Nucleus speckle
In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in axonal growth cone. Co-localizes with NEK6 at the nuclear speckles.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-711 (ISOFORM 2)
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Cited for: PHOSPHORYLATION AT SER-611;SUBCELLULAR LOCATION
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Cited for: FUNCTION;INTERACTION WITH KAT5;MUTAGENESIS OF CYS-655
Vaild Sequence:
