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Index > Protein center > ANAPC4(Gene name) > Human
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  • ANAPC4 (Gene name),
  • Anaphase-promoting complex subunit 4 (Protein name ),  APC4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ANAPC4(APC4);
    Protein name:
    Anaphase-promoting complex subunit 4(APC4);
    Alternative:
    Cyclosome subunit 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The APC/C is composed of at least 12 subunits.
    Function:
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    808
    Sequence:
    50:
    MLRFPTCFPS | FRVVGEKQLP | QEIIFLVWSP | KRDLIALANT | AGEVLLHRLA | 
    100:
    SFHRVWSFPP | NENTGKEVTC | LAWRPDGKLL | AFALADTKKI | VLCDVEKPES | 
    150:
    LHSFSVEAPV | SCMHWMEVTV | ESSVLTSFYN | AEDESNLLLP | KLPTLPKNYS | 
    200:
    NTSKIFSEEN | SDEIIKLLGD | VRLNILVLGG | SSGFIELYAY | GMFKIARVTG | 
    250:
    IAGTCLALCL | SSDLKSLSVV | TEVSTNGASE | VSYFQLETNL | LYSFLPEVTR | 
    300:
    MARKFTHISA | LLQYINLSLT | CMCEAWEEIL | MQMDSRLTKF | VQEKNTTTSV | 
    350:
    QDEFMHLLLW | GKASAELQTL | LMNQLTVKGL | KKLGQSIESS | YSSIQKLVIS | 
    400:
    HLQSGSESLL | YHLSELKGMA | SWKQKYEPLG | LDAAGIEEAI | TAVGSFILKA | 
    450:
    NELLQVIDSS | MKNFKAFFRW | LYVAMLRMTE | DHVLPELNKM | TQKDITFVAE | 
    500:
    FLTEHFNEAP | DLYNRKGKYF | NVERVGQYLK | DEDDDLVSPP | NTEGNQWYDF | 
    550:
    LQNSSHLKES | PLLFPYYPRK | SLHFVKRRME | NIIDQCLQKP | ADVIGKSMNQ | 
    600:
    AICIPLYRDT | RSEDSTRRLF | KFPFLWNNKT | SNLHYLLFTI | LEDSLYKMCI | 
    650:
    LRRHTDISQS | VSNGLIAIKF | GSFTYATTEK | VRRSIYSCLD | AQFYDDETVT | 
    700:
    VVLKDTVGRE | GRDRLLVQLP | LSLVYNSEDS | AEYQFTGTYS | TRLDEQCSAI | 
    750:
    PTRTMHFEKH | WRLLESMKAQ | YVAGNGFRKV | SCVLSSNLRH | VRVFEMDIDD | 
    800:
    EWELDESSDE | EEEASNKPVK | IKEEVLSESE | AENQQAGAAA | LAPEIVIKVE | 
    808:
    KLDPELDS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    Pfam:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human APC4
    ELISA Kit for Human APC4
    CLIA Kit for Human APC4
    CLIA Kit for Human APC4
    Polyclonal Antibody for Human APC4
    Polyclonal Antibody for Human APC4
    Monoclonal Antibody for Human APC4
    Monoclonal Antibody for Human APC4
    Protein for Human APC4
    Protein for Human APC4

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of a cullin homology region in a subunit of the anaphase-promoting complex."
      Yu H. , Peters J.-M. , King R.W. , Page A.M. , Hieter P. , Kirschner M.W.
      Science279:1219-1222(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBUNIT
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 434-808 (ISOFORM 2)
      tissue: Amygdala.
    6. 6.
      "Mitotic regulation of the human anaphase-promoting complex by phosphorylation."
      Kraft C. , Herzog F. , Gieffers C. , Mechtler K. , Hagting A. , Pines J. , Peters J.-M.
      EMBO J.22:6598-6609(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-469 AND SER-779
    7. 7.
      "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
      Jin L. , Williamson A. , Banerjee S. , Philipp I. , Rape M.
      Cell133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE APC/C
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757; SER-758; SER-777 AND SER-779;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."
      Dube P. , Herzog F. , Gieffers C. , Sander B. , Riedel D. , Mueller S.A. , Engel A. , Peters J.-M. , Stark H.
      Mol. Cell20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ELECTRON MICROSCOPY OF THE APC/C
    12. 12.
      "Molecular architecture and mechanism of the anaphase-promoting complex."
      Chang L. , Zhang Z. , Yang J. , McLaughlin S.H. , Barford D.
      Nature513:388-393(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE APC/C;SUBUNIT
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-155
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