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Index > Protein center > APCDD1(Gene name) > Human
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  • APCDD1 (Gene name),
  • Protein APCDD1 (Protein name ),  APCD1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    APCDD1(FP7019;DRAPC1);
    Protein name:
    Protein APCDD1;
    Alternative:
    Adenomatosis polyposis coli down-regulated 1 protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with LRP5 and WNT3A.
    Function:
    Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    514
    Sequence:
    50:
    MSWPRRLLLR | YLFPALLLHG | LGEGSALLHP | DSRSHPRSLE | KSAWRAFKES | 
    100:
    QCHHMLKHLH | NGARITVQMP | PTIEGHWVST | GCEVRSGPEF | ITRSYRFYHN | 
    150:
    NTFKAYQFYY | GSNRCTNPTY | TLIIRGKIRL | RQASWIIRGG | TEADYQLHNV | 
    200:
    QVICHTEAVA | EKLGQQVNRT | CPGFLADGGP | WVQDVAYDLW | REENGCECTK | 
    250:
    AVNFAMHELQ | LIRVEKQYLH | HNLDHLVEEL | FLGDIHTDAT | QRMFYRPSSY | 
    300:
    QPPLQNAKNH | DHACIACRII | YRSDEHHPPI | LPPKADLTIG | LHGEWVSQRC | 
    350:
    EVRPEVLFLT | RHFIFHDNNN | TWEGHYYHYS | DPVCKHPTFS | IYARGRYSRG | 
    400:
    VLSSRVMGGT | EFVFKVNHMK | VTPMDAATAS | LLNVFNGNEC | GAEGSWQVGI | 
    450:
    QQDVTHTNGC | VALGIKLPHT | EYEIFKMEQD | ARGRYLLFNG | QRPSDGSSPD | 
    500:
    RPEKRATSYQ | MPLVQCASSS | PRAEDLAEDS | GSSLYGRAPG | RHTWSLLLAA | 
    514:
    LACLVPLLHW | NIRR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein APCDD1
    ELISA Kit for Human Protein APCDD1
    ELISA Kit for Human Protein APCDD1
    CLIA Kit for Human Protein APCDD1
    CLIA Kit for Human Protein APCDD1
    CLIA Kit for Human Protein APCDD1
    Polyclonal Antibody for Human Protein APCDD1
    Polyclonal Antibody for Human Protein APCDD1
    Polyclonal Antibody for Human Protein APCDD1
    Monoclonal Antibody for Human Protein APCDD1
    Monoclonal Antibody for Human Protein APCDD1
    Monoclonal Antibody for Human Protein APCDD1
    Protein for Human Protein APCDD1
    Protein for Human Protein APCDD1
    Protein for Human Protein APCDD1

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    Precision
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    Linearity
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    References
    1. 1.
      "Isolation of a novel human gene, APCDD1, as a direct target of the b-catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis."
      Takahashi M. , Fujita M. , Furukawa Y. , Hamamoto R. , Shimokawa T. , Miwa N. , Ogawa M. , Nakamura Y.
      Cancer Res.62:5651-5656(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INDUCTION
      tissue: Colon.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Neuroepithelioma.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Ovary.
    4. 4.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-514
    5. 5.
      "APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex."
      Shimomura Y. , Agalliu D. , Vonica A. , Luria V. , Wajid M. , Baumer A. , Belli S. , Petukhova L. , Schinzel A. , Brivanlou A.H. , Barres B.A. , Christiano A.M.
      Nature464:1043-1047(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HYPT1 ARG-9;CHARACTERIZATION OF VARIANT HYPT1 ARG-9;GLYCOSYLATION;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;SUBUNIT;INTERACTION WITH LRP5 AND WNT3A
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