Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > Apex2(Gene name) > Mouse
  • Add your favorite
  • Apex2 (Gene name),
  • DNA-(apurinic or apyrimidinic site) lyase 2 (Protein name ),  APEX2_MOUSE from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    Apex2(Ape2);
    Protein name:
    DNA-(apurinic or apyrimidinic site) lyase 2;
    Alternative:
    Apurinic-apyrimidinic endonuclease 2(AP endonuclease 2);APEX nuclease 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PCNA. This interaction is increased by misincorporation of uracil in nuclear DNA.
    Function:
    Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
    Subcellular Location:
    Nucleus Cytoplasm Mitochondrion Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
    Protein Attributes:
    Sequence length:
    516
    Sequence:
    50:
    MLRVVSWNIN | GIRSPLQGLA | CQEPSSCPTA | LRRVLDELDA | DIVCLQETKV | 
    100:
    TRDVLTEPLA | IVEGYNSYFS | FSRSRSGYSG | VATFCKDSAT | PVAAEEGLSG | 
    150:
    VFATLNGDIG | CYGNMDEFTQ | EELRVLDSEG | RALLTQHKIR | TLEGKEKTLT | 
    200:
    LINVYCPHAD | PGKPERLTFK | MRFYRLLQMR | AEALLAAGSH | VIILGDLNTA | 
    250:
    HRPIDHCDAS | SLECFEEDPG | RKWMDGLLSN | PGDEAGPHIG | LFMDSYRYLH | 
    300:
    PKQQRAFTCW | SVVSGARHLN | YGSRLDYVLG | DRALVIDTFQ | ASFLLPEVMG | 
    350:
    SDHCPVGAVL | NVSCVPAKQC | PALCTRFLPE | FAGTQLKILR | FLVPLEQEPV | 
    400:
    REQQVLQPSH | QIQAQRQPRK | ACMHSTRLRK | SQGGPKRKQK | NLMSYFQPSS | 
    450:
    SLSQTSGVEL | PTLPLVGPLT | TPKTAEEVAT | ATVLEEKNKV | PESKDEKGER | 
    500:
    TAFWKSMLSG | PSPMPLCGGH | REPCVMRTVK | KTGPNFGRQF | YMCARPRGPP | 
    516:
    SDPSSRCNFF | LWSRPS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    ELISA Kit for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    ELISA Kit for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    CLIA Kit for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    CLIA Kit for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    CLIA Kit for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Polyclonal Antibody for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Polyclonal Antibody for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Polyclonal Antibody for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Monoclonal Antibody for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Monoclonal Antibody for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Monoclonal Antibody for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Protein for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Protein for Mouse DNA-(apurinic or apyrimidinic site) lyase 2
    Protein for Mouse DNA-(apurinic or apyrimidinic site) lyase 2

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Characterization of the genomic structure and expression of the mouse Apex2 gene."
      Ide Y. , Tsuchimoto D. , Tominaga Y. , Iwamoto Y. , Nakabeppu Y.
      Genomics81:47-57(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH PCNA;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      strain: 129/Sv.
      strain: C57BL/6.
      tissue: B-cell.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1/2/4/5)
      strain: NOD.
      tissue: Adipose tissue.
      tissue: Head.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      strain: FVB/N-3.
      tissue: Mammary tumor.
    4. 4.
      "Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice."
      Ide Y. , Tsuchimoto D. , Tominaga Y. , Nakashima M. , Watanabe T. , Sakumi K. , Ohno M. , Nakabeppu Y.
      Blood104:4097-4103(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
    5. 5.
      "APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination."
      Guikema J.E. , Linehan E.K. , Tsuchimoto D. , Nakabeppu Y. , Strauss P.R. , Stavnezer J. , Schrader C.E.
      J. Exp. Med.204:3017-3026(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION
    6. 6.
      "Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes."
      Sabouri Z. , Okazaki I.M. , Shinkura R. , Begum N. , Nagaoka H. , Tsuchimoto D. , Nakabeppu Y. , Honjo T.
      Int. Immunol.21:947-955(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5
    Top Searches
    Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Alpha Tumor necrosis Asprosin TRAP1A
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

    Copyright & copy www.eiaab.com2006-2026 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    鄂ICP备10015095号-1

    鄂公网安备 42018502005535号

    Twitter