Protein name:
Gamma-secretase subunit APH-1B (APH-1b) ;
Alternative:
Aph-1beta ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist (By similarity). Interacts with PSEN1 and PSEN2.
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MTAAVFFGCA | FIAFGPALAL | YVFTIATDPL | RVIFLIAGAF | FWLVSLLLSS |
100:
VFWFLVRVIT | DNRDGPVQNY | LLIFGVLLSV | CIQELFRLAY | YKLLKKASEG |
150:
LKSINPEETA | PSMRLLAYVS | GLGFGIMSGV | FSFVNTLSNS | LGPGTVGIHG |
200:
DSPQFFLNSA | FMTLVVIMLH | VFWGVVFFDG | CEKNKWYTLL | TVLLTHLVVS |
250:
TQTFLSPYYE | VNLVTAYIIM | VLMGIWAFYV | AGGSCRSLKL | CLLCQDKDFL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse APH-1b
ELISA Kit for Mouse APH-1b
CLIA Kit for Mouse APH-1b
CLIA Kit for Mouse APH-1b
Polyclonal Antibody for Mouse APH-1b
Polyclonal Antibody for Mouse APH-1b
Monoclonal Antibody for Mouse APH-1b
Monoclonal Antibody for Mouse APH-1b
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6J .
strain :
NOD .
tissue :
Hippocampus .
tissue :
Skin .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
tissue :
Brain .