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Index > Protein center > Aph1b(Gene name) > Mouse
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  • Aph1b (Gene name),
  • Gamma-secretase subunit APH-1B (Protein name ),  APH1B_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Aph1b;
    Protein name:
    Gamma-secretase subunit APH-1B(APH-1b);
    Alternative:
    Aph-1beta;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist (By similarity). Interacts with PSEN1 and PSEN2.
    Function:
    Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    257
    Sequence:
    50:
    MTAAVFFGCA | FIAFGPALAL | YVFTIATDPL | RVIFLIAGAF | FWLVSLLLSS | 
    100:
    VFWFLVRVIT | DNRDGPVQNY | LLIFGVLLSV | CIQELFRLAY | YKLLKKASEG | 
    150:
    LKSINPEETA | PSMRLLAYVS | GLGFGIMSGV | FSFVNTLSNS | LGPGTVGIHG | 
    200:
    DSPQFFLNSA | FMTLVVIMLH | VFWGVVFFDG | CEKNKWYTLL | TVLLTHLVVS | 
    250:
    TQTFLSPYYE | VNLVTAYIIM | VLMGIWAFYV | AGGSCRSLKL | CLLCQDKDFL | 
    257:
    LYNQRSR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse APH-1b
    ELISA Kit for Mouse APH-1b
    CLIA Kit for Mouse APH-1b
    CLIA Kit for Mouse APH-1b
    Polyclonal Antibody for Mouse APH-1b
    Polyclonal Antibody for Mouse APH-1b
    Monoclonal Antibody for Mouse APH-1b
    Monoclonal Antibody for Mouse APH-1b
    Protein for Mouse APH-1b
    Protein for Mouse APH-1b

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Hippocampus.
      tissue: Skin.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
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