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Index > Protein center > API5(Gene name) > Human
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  • API5 (Gene name),
  • Apoptosis inhibitor 5 (Protein name ),  API5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    API5(MIG8);
    Protein name:
    Apoptosis inhibitor 5(API-5);
    Alternative:
    Cell migration-inducing gene 8 protein;Antiapoptosis clone 11 protein(AAC-11);Protein XAGL;Fibroblast growth factor 2-interacting factor(FIF);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homooligomer. Interacts with FGF2 and ACIN1.
    Function:
    Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
    Subcellular Location:
    Isoform 3 Cytoplasm
    Protein Attributes:
    Sequence length:
    524
    Sequence:
    50:
    MPTVEELYRN | YGILADATEQ | VGQHKDAYQV | ILDGVKGGTK | EKRLAAQFIP | 
    100:
    KFFKHFPELA | DSAINAQLDL | CEDEDVSIRR | QAIKELPQFA | TGENLPRVAD | 
    150:
    ILTQLLQTDD | SAEFNLVNNA | LLSIFKMDAK | GTLGGLFSQI | LQGEDIVRER | 
    200:
    AIKFLSTKLK | TLPDEVLTKE | VEELILTESK | KVLEDVTGEE | FVLFMKILSG | 
    250:
    LKSLQTVSGR | QQLVELVAEQ | ADLEQTFNPS | DPDCVDRLLQ | CTRQAVPLFS | 
    300:
    KNVHSTRFVT | YFCEQVLPNL | GTLTTPVEGL | DIQLEVLKLL | AEMSSFCGDM | 
    350:
    EKLETNLRKL | FDKLLEYMPL | PPEEAENGEN | AGNEEPKLQF | SYVECLLYSF | 
    400:
    HQLGRKLPDF | LTAKLNAEKL | KDFKIRLQYF | ARGLQVYIRQ | LRLALQGKTG | 
    450:
    EALKTEENKI | KVVALKITNN | INVLIKDLFH | IPPSYKSTVT | LSWKPVQKVE | 
    500:
    IGQKRASEDT | TSGSPPKKSS | AGPKRDARQI | YNPPSGKYSS | NLGNFNYEQR | 
    524:
    GAFRGSRGGR | GWGTRGNRSR | GRLY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    SMR:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human API-5
    ELISA Kit for Human API-5
    ELISA Kit for Human API-5
    CLIA Kit for Human API-5
    CLIA Kit for Human API-5
    CLIA Kit for Human API-5
    Polyclonal Antibody for Human API-5
    Polyclonal Antibody for Human API-5
    Polyclonal Antibody for Human API-5
    Monoclonal Antibody for Human API-5
    Monoclonal Antibody for Human API-5
    Monoclonal Antibody for Human API-5
    Protein for Human API-5
    Protein for Human API-5
    Protein for Human API-5

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal."
      Tewari M. , Yu M. , Ross B. , Dean C. , Giordano A. , Rubin R.
      Cancer Res.57:4063-4069(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    2. 2.
      "Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene."
      Gianfrancesco F. , Esposito T. , Ciccodicola A. , D'Esposito M. , Mazzarella R. , D'Urso M. , Forabosco A.
      Cytogenet. Cell Genet.84:164-166(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2."
      Van den Berghe L. , Laurell H. , Huez I. , Zanibellato C. , Prats H. , Bugler B.
      Mol. Endocrinol.14:1709-1724(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [MRNA] OF 72-524 (ISOFORM 1);IDENTIFICATION OF ISOFORM 3;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH FGF2
      tissue: Liver.
    4. 4.
      "Identification of a human cell migration gene."
      Kim J.W.
      Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    6. 6.
      NIEHS SNPs program
      Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-276; VAL-300 AND SER-493
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5)
      tissue: Brain.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Lymph.
    11. 11.
      Bienvenut W.V. , Lilla S. , von Kriegsheim A. , Lempens A. , Kolch W.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-9; 26-36; 131-148; 161-169; 244-251 AND 427-436;CLEAVAGE OF INITIATOR METHIONINE;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Ovarian carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 384-524 (ISOFORM 3)
    13. 13.
      "AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis."
      Kim J.W. , Cho H.S. , Kim J.H. , Hur S.Y. , Kim T.E. , Lee J.M. , Kim I.K. , Namkoong S.E.
      Lab. Invest.80:587-594(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    14. 14.
      "Expression of the antiapoptosis gene, AAC-11, as a prognosis marker in non-small cell lung cancer."
      Sasaki H. , Moriyama S. , Yukiue H. , Kobayashi Y. , Nakashima Y. , Kaji M. , Fukai I. , Kiriyama M. , Yamakawa Y. , Fujii Y.
      Lung Cancer34:53-57(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    15. 15.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo."
      Morris E.J. , Michaud W.A. , Ji J.Y. , Moon N.S. , Rocco J.W. , Dyson N.J.
      PLoS Genet.2:E196-E196(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "The antiapoptotic protein Api5 and its partner, high molecular weight FGF2, are up-regulated in B cell chronic lymphoid leukemia."
      Krejci P. , Pejchalova K. , Rosenbloom B.E. , Rosenfelt F.P. , Tran E.L. , Laurell H. , Wilcox W.R.
      J. Leukoc. Biol.82:1363-1364(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    18. 18.
      "The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation."
      Rigou P. , Piddubnyak V. , Faye A. , Rain J.-C. , Michel L. , Calvo F. , Poyet J.-L.
      EMBO J.28:1576-1588(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ACIN1;TISSUE SPECIFICITY
    19. 19.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-462 AND SER-464;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules."
      Han B.G. , Kim K.H. , Lee S.J. , Jeong K.C. , Cho J.W. , Noh K.H. , Kim T.W. , Kim S.J. , Yoon H.J. , Suh S.W. , Lee S. , Lee B.I.
      J. Biol. Chem.287:10727-10737(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-498 OF WILD-TYPE AND MUTANT GLN-251;NUCLEAR LOCALIZATION SIGNAL;ACETYLATION AT LYS-251;REPEATS;SUBUNIT
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