Protein name:
Apoptosis inhibitor 5 (API-5) ;
Alternative:
Cell migration-inducing gene 8 protein ;Antiapoptosis clone 11 protein (AAC-11) ;Protein XAGL ;Fibroblast growth factor 2-interacting factor (FIF) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homooligomer. Interacts with FGF2 and ACIN1.
Function:
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Subcellular Location:
Isoform 3
Cytoplasm
Protein Attributes:
50:
MPTVEELYRN | YGILADATEQ | VGQHKDAYQV | ILDGVKGGTK | EKRLAAQFIP |
100:
KFFKHFPELA | DSAINAQLDL | CEDEDVSIRR | QAIKELPQFA | TGENLPRVAD |
150:
ILTQLLQTDD | SAEFNLVNNA | LLSIFKMDAK | GTLGGLFSQI | LQGEDIVRER |
200:
AIKFLSTKLK | TLPDEVLTKE | VEELILTESK | KVLEDVTGEE | FVLFMKILSG |
250:
LKSLQTVSGR | QQLVELVAEQ | ADLEQTFNPS | DPDCVDRLLQ | CTRQAVPLFS |
300:
KNVHSTRFVT | YFCEQVLPNL | GTLTTPVEGL | DIQLEVLKLL | AEMSSFCGDM |
350:
EKLETNLRKL | FDKLLEYMPL | PPEEAENGEN | AGNEEPKLQF | SYVECLLYSF |
400:
HQLGRKLPDF | LTAKLNAEKL | KDFKIRLQYF | ARGLQVYIRQ | LRLALQGKTG |
450:
EALKTEENKI | KVVALKITNN | INVLIKDLFH | IPPSYKSTVT | LSWKPVQKVE |
500:
IGQKRASEDT | TSGSPPKKSS | AGPKRDARQI | YNPPSGKYSS | NLGNFNYEQR |
524:
GAFRGSRGGR | GWGTRGNRSR | GRLY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Mouse
Human
ELISA Kit for Human API-5
ELISA Kit for Human API-5
ELISA Kit for Human API-5
Polyclonal Antibody for Human API-5
Polyclonal Antibody for Human API-5
Polyclonal Antibody for Human API-5
Monoclonal Antibody for Human API-5
Monoclonal Antibody for Human API-5
Monoclonal Antibody for Human API-5
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-498 OF WILD-TYPE AND MUTANT GLN-251;NUCLEAR LOCALIZATION SIGNAL;ACETYLATION AT LYS-251;REPEATS;SUBUNIT