Protein name:
Aquaporin-2 (AQP-2) ;
Alternative:
Aquaporin-CD (AQP-CD) ;ADH water channel ;WCH-CD ;Collecting duct water channel protein ;Water channel protein for renal collecting duct ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular Location:
Apical cell membrane
Multi-pass membrane protein
Cytoplasmic vesicle membrane
Multi-pass membrane protein
Shuttles from vesicles to the apical membrane.
Protein Attributes:
50:
MWELRSIAFS | RAVFAEFLAT | LLFVFFGLGS | ALNWPQALPS | VLQIAMAFGL |
100:
GIGTLVQALG | HISGAHINPA | VTVACLVGCH | VSVLRAAFYV | AAQLLGAVAG |
150:
AALLHEITPA | DIRGDLAVNA | LSNSTTAGQA | VTVELFLTLQ | LVLCIFASTD |
200:
ERRGENPGTP | ALSIGFSVAL | GHLLGIHYTG | CSMNPARSLA | PAVVTGKFDD |
250:
HWVFWIGPLV | GAILGSLLYN | YVLFPPAKSL | SERLAVLKGL | EPDTDWEERE |
271:
VRRRQSVELH | SPQSLPRGTK | A
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Mouse
Human
Dog
Rabbit
ELISA Kit for Human AQP-2
ELISA Kit for Human AQP-2
ELISA Kit for Human AQP-2
ELISA Kit for Human AQP-2
ELISA Kit for Human AQP-2
ELISA Kit for Human AQP-2
Polyclonal Antibody for Human AQP-2
Polyclonal Antibody for Human AQP-2
Polyclonal Antibody for Human AQP-2
Polyclonal Antibody for Human AQP-2
Polyclonal Antibody for Human AQP-2
Polyclonal Antibody for Human AQP-2
Monoclonal Antibody for Human AQP-2
Monoclonal Antibody for Human AQP-2
Monoclonal Antibody for Human AQP-2
Monoclonal Antibody for Human AQP-2
Monoclonal Antibody for Human AQP-2
Monoclonal Antibody for Human AQP-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ANDI ARG-64; CYS-187 AND PRO-216
4.
"Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct."
Sasaki S.
,
Fushimi K.
,
Saito H.
,
Saito F.
,
Uchida S.
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Ishibashi K.
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Kuwahara M.
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Ikeuchi T.
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Inui K.
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Nakajima K.
J. Clin. Invest.93:1250-1256(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Kidney .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Kidney .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Colon .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-256;MUTAGENESIS OF SER-148; SER-229; SER-231; THR-244 AND SER-256
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ANDI CYS-202
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI VAL-22 AND TRP-181
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI SER-68; MET-126 AND THR-147
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI MET-168 AND PRO-216
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI MET-125; ARG-175; THR-190 AND LEU-262
13.
"An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex."
Mulders S.M.
,
Bichet D.G.
,
Rijss J.P.L.
,
Kamsteeg E.-J.
,
Arthus M.-F.
,
Lonergan M.
,
Fujiwara M.
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Morgan K.
,
Leijendekker R.
,
van der Sluijs P.
,
van Os C.H.
,
Deen P.M.T.
J. Clin. Invest.102:57-66(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ANDI LYS-258
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI MET-125 AND ARG-175
15.
"Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus."
Marr N.
,
Bichet D.G.
,
Hoefs S.
,
Savelkoul P.J.M.
,
Konings I.B.
,
De Mattia F.
,
Graat M.P.
,
Arthus M.-F.
,
Lonergan M.
,
Fujiwara T.M.
,
Knoers N.V.
,
Landau D.
,
Balfe W.J.
,
Oksche A.
,
Rosenthal W.
,
Muller D.
,
Van Os C.H.
,
Deen P.M.
J. Am. Soc. Nephrol.13:2267-2277(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI PRO-28; VAL-47; MET-71; MET-125; ARG-175 AND ALA-185;VARIANT ILE-194
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI PRO-57 AND VAL-100
17.
"A novel mechanism in recessive nephrogenic diabetes insipidus: wild-type aquaporin-2 rescues the apical membrane expression of intracellularly retained AQP2-P262L."
de Mattia F.
,
Savelkoul P.J.M.
,
Bichet D.G.
,
Kamsteeg E.-J.
,
Konings I.B.M.
,
Marr N.
,
Arthus M.-F.
,
Lonergan M.
,
van Os C.H.
,
van der Sluijs P.
,
Robertson G.
,
Deen P.M.T.
Hum. Mol. Genet.13:3045-3056(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI CYS-187; THR-190 AND LEU-262;CHARACTERIZATION OF VARIANTS ANDI CYS-187; THR-190 AND LEU-262
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ANDI LEU-254;CHARACTERIZATION OF VARIANT ANDI LEU-254
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI ASP-70 AND HIS-187
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ANDI ARG-100 AND SER-180
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN ANDI;VARIANT ANDI GLN-254;CHARACTERIZATION OF VARIANT ANDI GLN-254
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MISSORTING MOTIF OF VARIANT ANDI LYS-258
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ANDI MET-108