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Index > Protein center > AQR(Gene name) > Human
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  • AQR (Gene name),
  • Intron-binding protein aquarius (Protein name ),  AQR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    AQR(KIAA0560);
    Protein name:
    Intron-binding protein aquarius;
    Alternative:
    Intron-binding protein of 160 kDa(IBP160);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Identified in the spliceosome C complec.
    Function:
    Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
    Subcellular Location:
    Nucleus Localizes to speckle-like regions of the nucleoplasm.
    Protein Attributes:
    Sequence length:
    1485
    Sequence:
    50:
    MAAPAQPKKI | VAPTVSQINA | EFVTQLACKY | WAPHIKKKSP | FDIKVIEDIY | 
    100:
    EKEIVKSRFA | IRKIMLLEFS | QYLENYLWMN | YSPEVSSKAY | LMSICCMVNE | 
    150:
    KFRENVPAWE | IFKKKPDHFP | FFFKHILKAA | LAETDGEFSL | HEQTVLLLFL | 
    200:
    DHCFNSLEVD | LIRSQVQQLI | SLPMWMGLQL | ARLELELKKT | PKLRKFWNLI | 
    250:
    KKNDEKMDPE | AREQAYQERR | FLSQLIQKFI | SVLKSVPLSE | PVTMDKVHYC | 
    300:
    ERFIELMIDL | EALLPTRRWF | NTILDDSHLL | VHCYLSNLVR | REEDGHLFSQ | 
    350:
    LLDMLKFYTG | FEINDQTGNA | LTENEMTTIH | YDRITSLQRA | AFAHFPELYD | 
    400:
    FALSNVAEVD | TRESLVKFFG | PLSSNTLHQV | ASYLCLLPTL | PKNEDTTFDK | 
    450:
    EFLLELLVSR | HERRISQIQQ | LNQMPLYPTE | KIIWDENIVP | TEYYSGEGCL | 
    500:
    ALPKLNLQFL | TLHDYLLRNF | NLFRLESTYE | IRQDIEDSVS | RMKPWQSEYG | 
    550:
    GVVFGGWARM | AQPIVAFTVV | EVAKPNIGEN | WPTRVRADVT | INLNVRDHIK | 
    600:
    DEWEGLRKHD | VCFLITVRPT | KPYGTKFDRR | RPFIEQVGLV | YVRGCEIQGM | 
    650:
    LDDKGRVIED | GPEPRPNLRG | ESRTFRVFLD | PNQYQQDMTN | TIQNGAEDVY | 
    700:
    ETFNIIMRRK | PKENNFKAVL | ETIRNLMNTD | CVVPDWLHDI | ILGYGDPSSA | 
    750:
    HYSKMPNQIA | TLDFNDTFLS | IEHLKASFPG | HNVKVTVEDP | ALQIPPFRIT | 
    800:
    FPVRSGKGKK | RKDADVEDED | TEEAKTLIVE | PHVIPNRGPY | PYNQPKRNTI | 
    850:
    QFTHTQIEAI | RAGMQPGLTM | VVGPPGTGKT | DVAVQIISNI | YHNFPEQRTL | 
    900:
    IVTHSNQALN | QLFEKIMALD | IDERHLLRLG | HGEEELETEK | DFSRYGRVNY | 
    950:
    VLARRIELLE | EVKRLQKSLG | VPGDASYTCE | TAGYFFLYQV | MSRWEEYISK | 
    1000:
    VKNKGSTLPD | VTEVSTFFPF | HEYFANAPQP | IFKGRSYEED | MEIAEGCFRH | 
    1050:
    IKKIFTQLEE | FRASELLRSG | LDRSKYLLVK | EAKIIAMTCT | HAALKRHDLV | 
    1100:
    KLGFKYDNIL | MEEAAQILEI | ETFIPLLLQN | PQDGFSRLKR | WIMIGDHHQL | 
    1150:
    PPVIKNMAFQ | KYSNMEQSLF | TRFVRVGVPT | VDLDAQGRAR | ASLCNLYNWR | 
    1200:
    YKNLGNLPHV | QLLPEFSTAN | AGLLYDFQLI | NVEDFQGVGE | SEPNPYFYQN | 
    1250:
    LGEAEYVVAL | FMYMCLLGYP | ADKISILTTY | NGQKHLIRDI | INRRCGNNPL | 
    1300:
    IGRPNKVTTV | DRFQGQQNDY | ILLSLVRTRA | VGHLRDVRRL | VVAMSRARLG | 
    1350:
    LYIFARVSLF | QNCFELTPAF | SQLTARPLHL | HIIPTEPFPT | TRKNGERPSH | 
    1400:
    EVQIIKNMPQ | MANFVYNMYM | HLIQTTHHYH | QTLLQLPPAM | VEEGEEVQNQ | 
    1450:
    ETELETEEEA | MTVQADIIPS | PTDTSCRQET | PAFQTDTTPS | ETGATSTPEA | 
    1485:
    IPALSETTPT | VVGAVSAPAE | ANTPQDATSA | PEETK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Intron-binding protein aquarius
    ELISA Kit for Human Intron-binding protein aquarius
    CLIA Kit for Human Intron-binding protein aquarius
    CLIA Kit for Human Intron-binding protein aquarius
    Polyclonal Antibody for Human Intron-binding protein aquarius
    Polyclonal Antibody for Human Intron-binding protein aquarius
    Monoclonal Antibody for Human Intron-binding protein aquarius
    Monoclonal Antibody for Human Intron-binding protein aquarius
    Protein for Human Intron-binding protein aquarius
    Protein for Human Intron-binding protein aquarius

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cervix.
      tissue: Mammary gland.
    4. 4.
      "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S. , Licklider L.J. , Gygi S.P. , Grigorieff N. , Moore M.J.
      RNA8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX
    5. 5.
      "A spliceosomal intron binding protein, IBP160, links Position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing."
      Hirose T. , Ideue T. , Nagai M. , Hagiwara M. , Shu M.-D. , Steitz J.A.
      Mol. Cell23:673-684(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;RNA-BINDING;SUBCELLULAR LOCATION
    6. 6.
      "Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair."
      Kuraoka I. , Ito S. , Wada T. , Hayashida M. , Lee L. , Saijo M. , Nakatsu Y. , Matsumoto M. , Matsunaga T. , Handa H. , Qin J. , Nakatani Y. , Tanaka K.
      J. Biol. Chem.283:940-950(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS PART OF THE XAB2 COMPLEX
    7. 7.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1051;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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