ARAP3 ELISA Kit for Human(Homo sapiens) | EIAab.comARAP3 ELISA Kit for Human(Homo sapiens) | EIAab.com

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ARAP3 (Gene name),

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Protein name ), ARAP3_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

ARAP3(CENTD3);

Protein name:

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3;

Alternative:

Centaurin-delta-3(Cnt-d3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with INPPL1/SHIP2.

Function:

Phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.

Subcellular Location:

Cytoplasm Cytoplasm cytoskeleton Cell membrane Peripheral membrane protein Cell projection lamellipodium Cell projection ruffle Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia.

Protein Attributes:

Sequence length:

1544

Sequence:

50:

MAAPQDLDIA | VWLATVHLEQ | YADTFRRHGL | ATAGAARGLG | HEELKQLGIS |

100:

ATGHRKRILR | LLQTGTEEGS | LDPKSDSAME | PSPSPAPQAQ | PPKPVPKPRT |

150:

VFGGLSGPAT | TQRPGLSPAL | GGPGVSRSPE | PSPRPPPLPT | SSSEQSSALN |

200:

TVEMMPNSIY | FGLDSRGRAQ | AAQDKAPDSS | QISAPTPALR | PTTGTVHIMD |

250:

PGCLYYGVQP | VGTPGAPDRR | ESRGVCQGRA | EHRLSRQDLE | AREDAGYASL |

300:

ELPGDSTLLS | PTLETEETSD | DLISPYASFS | FTADRLTPLL | SGWLDKLSPQ |

350:

GNYVFQRRFV | QFNGRSLMYF | GSDKDPFPKG | VIPLTAIEMT | RSSKDNKFQV |

400:

ITGQRVFVFR | TESEAQRDMW | CSTLQSCLKE | QRLLGHPRPP | QPPRPLRTGM |

450:

LELRGHKAKV | FAALSPGELA | LYKSEQAFSL | GIGICFIELQ | GCSVRETKSR |

500:

SFDLLTPHRC | FSFTAESGGA | RQSWAAALQE | AVTETLSDYE | VAEKIWSNRA |

550:

NRQCADCGSS | RPDWAAVNLG | VVICKQCAGQ | HRALGSGISK | VQSLKLDTSV |

600:

WSNEIVQLFI | VLGNDRANRF | WAGTLPPGEG | LHPDATPGPR | GEFISRKYRL |

650:

GLFRKPHPQY | PDHSQLLQAL | CAAVARPNLL | KNMTQLLCVE | AFEGEEPWFP |

700:

PAPDGSCPGL | LPSDPSPGVY | NEVVVRATYS | GFLYCSPVSN | KAGPSPPRRG |

750:

RDAPPRLWCV | LGAALEMFAS | ENSPEPLSLI | QPQDIVCLGV | SPPPTDPGDR |

800:

FPFSFELILA | GGRIQHFGTD | GADSLEAWTS | AVGKWFSPLS | CHQLLGPGLL |

850:

RLGRLWLRSP | SHTAPAPGLW | LSGFGLLRGD | HLFLCSAPGP | GPPAPEDMVH |

900:

LRRLQEISVV | SAADTPDKKE | HLVLVETGRT | LYLQGEGRLD | FTAWNAAIGG |

950:

AAGGGGTGLQ | EQQMSRGDIP | IIVDACISFV | TQHGLRLEGV | YRKGGARARS |

1000:

LRLLAEFRRD | ARSVKLRPGE | HFVEDVTDTL | KRFFRELDDP | VTSARLLPRW |

1050:

REAAELPQKN | QRLEKYKDVI | GCLPRVNRRT | LATLIGHLYR | VQKCAALNQM |

1100:

CTRNLALLFA | PSVFQTDGRG | EHEVRVLQEL | IDGYISVFDI | DSDQVAQIDL |

1150:

EVSLITTWKD | VQLSQAGDLI | MEVYIEQQLP | DNCVTLKVSP | TLTAEELTNQ |

1200:

VLEMRGTAAG | MDLWVTFEIR | EHGELERPLH | PKEKVLEQAL | QWCQLPEPCS |

1250:

ASLLLKKVPL | AQAGCLFTGI | RRESPRVGLL | RCREEPPRLL | GSRFQERFFL |

1300:

LRGRCLLLLK | EKKSSKPERE | WPLEGAKVYL | GIRKKLKPPT | PWGFTLILEK |

1350:

MHLYLSCTDE | DEMWDWTTSI | LKAQHDDQQP | VVLRRHSSSD | LARQKFGTMP |

1400:

LLPIRGDDSG | ATLLSANQTL | RRLHNRRTLS | MFFPMKSSQG | SVEEQEELEE |

1450:

PVYEEPVYEE | VGAFPELIQD | TSTSFSTTRE | WTVKPENPLT | SQKSLDQPFL |

1500:

SKSSTLGQEE | RPPEPPPGPP | SKSSPQARGS | LEEQLLQELS | SLILRKGETT |

1544:

AGLGSPSQPS | SPQSPSPTGL | PTQTPGFPTQ | PPCTSSPPSS | QPLT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

SMR:

Pfam:

String:

STRING:

9606.ENSP00000239440

KEGG:

MIM:

Uniprot:

FOR

ELISA Kit for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

ELISA Kit for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

CLIA Kit for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

CLIA Kit for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Polyclonal Antibody for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Polyclonal Antibody for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Monoclonal Antibody for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Monoclonal Antibody for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Protein for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Protein for Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

R&D Technical Data

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Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices."
Krugmann S. , Anderson K.E. , Ridley S.H. , Risso N. , McGregor A. , Coadwell J. , Davidson K. , Eguinoa A. , Ellson C.D. , Lipp P. , Manifava M. , Ktistakis N. , Painter G. , Thuring J.W. , Cooper M.A. , Lim Z.-Y. , Holmes A.B. , Dove S.K. , more...
Mol. Cell9:95-108(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF 307-ARG-ARG-308;FUNCTION;INTERACTION WITH PHOSPHATIDYLINOSITOL 3-PHOSPHATE
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Hippocampus.
3.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"GTPase signaling: bridging the GAP between ARF and Rho."
Santy L.C. , Casanova J.E.
Curr. Biol.12:R360-R362(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
6.

"EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin."
Lu Q. , Wei W. , Kowalski P.E. , Chang A.C.Y. , Cohen S.N.
Proc. Natl. Acad. Sci. U.S.A.101:17246-17251(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN THE INTERNALIZATION OF ANTHRAX TOXIN
7.

"The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner."
Raaijmakers J.H. , Deneubourg L. , Rehmann H. , de Koning J. , Zhang Z. , Krugmann S. , Erneux C. , Bos J.L.
Cell. Signal.19:1249-1257(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INPPL1
8.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1444;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1444 AND SER-1480;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam."
Leone M. , Cellitti J. , Pellecchia M.
BMC Struct. Biol.9:59-59(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-80;INTERACTION WITH INPPL1
12.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-471; MET-1085 AND PRO-1428

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