ADRBK1 ELISA Kit for Bovine(Bos taurus) | EIAab.comADRBK1 ELISA Kit for Bovine(Bos taurus)

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Index > Protein center > ADRBK1(Gene name) > Bovine

ADRBK1 (Gene name),

Beta-adrenergic receptor kinase 1 (Protein name ), ARBK1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ADRBK1(GRK2);

Protein name:

Beta-adrenergic receptor kinase 1(Beta-ARK-1);

Alternative:

G-protein-coupled receptor kinase 2;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Interacts with GIT1. Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1.

Function:

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

689

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

689:

YREAQQLVQR | VPKMKNKPRS | PVVELSKVPL | IQRGSANGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P21146

KEGG:

bta:282682

Pfam:

PF00169

STRING:

9913.ENSBTAP00000050806

UniGene:

Bt.4693

String:

P21146

Uniprot:

P21146

FOR

ELISA Kit for Bovine Beta-ARK-1

CLIA Kit for Bovine Beta-ARK-1

Polyclonal Antibody for Bovine Beta-ARK-1

Monoclonal Antibody for Bovine Beta-ARK-1

Protein for Bovine Beta-ARK-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Beta-adrenergic receptor kinase: primary structure delineates a multigene family."
Benovic J.L. , Deblasi A. , Stone W.C. , Caron M.G. , Lefkowitz R.J.
Science246:235-240(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
2.

"Beta2-adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein."
Premont R.T. , Claing A. , Vitale N. , Freeman J.L.R. , Pitcher J.A. , Patton W.A. , Moss J. , Vaughan M. , Lefkowitz R.J.
Proc. Natl. Acad. Sci. U.S.A.95:14082-14087(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GIT1

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