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Index > Protein center > ARF1(Gene name) > Human
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  • ARF1 (Gene name),
  • ADP-ribosylation factor 1 (Protein name ),  ARF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ARF1;
    Protein name:
    ADP-ribosylation factor 1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PRKCABP, GGA1, ASAP2 and PIP5K1A (By similarity). Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Binds ASAP2. Interacts with HERC1 and ARHGAP21. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. This interaction at the plasm membrane requires a myristoylated NCS1/FREQ.
    Function:
    GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
    Subcellular Location:
    Golgi apparatus Cytoplasm perinuclear region
    Protein Attributes:
    Sequence length:
    181
    Sequence:
    50:
    MGNIFANLFK | GLFGKKEMRI | LMVGLDAAGK | TTILYKLKLG | EIVTTIPTIG | 
    100:
    FNVETVEYKN | ISFTVWDVGG | QDKIRPLWRH | YFQNTQGLIF | VVDSNDRERV | 
    150:
    NEAREELMRM | LAEDELRDAV | LLVFANKQDL | PNAMNAAEIT | DKLGLHSLRH | 
    181:
    RNWYIQATCA | TSGDGLYEGL | DWLSNQLRNQ | K
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human ADP-ribosylation factor 1
    ELISA Kit for Human ADP-ribosylation factor 1
    ELISA Kit for Human ADP-ribosylation factor 1
    ELISA Kit for Human ADP-ribosylation factor 1
    CLIA Kit for Human ADP-ribosylation factor 1
    CLIA Kit for Human ADP-ribosylation factor 1
    CLIA Kit for Human ADP-ribosylation factor 1
    CLIA Kit for Human ADP-ribosylation factor 1
    Polyclonal Antibody for Human ADP-ribosylation factor 1
    Polyclonal Antibody for Human ADP-ribosylation factor 1
    Polyclonal Antibody for Human ADP-ribosylation factor 1
    Polyclonal Antibody for Human ADP-ribosylation factor 1
    Monoclonal Antibody for Human ADP-ribosylation factor 1
    Monoclonal Antibody for Human ADP-ribosylation factor 1
    Monoclonal Antibody for Human ADP-ribosylation factor 1
    Monoclonal Antibody for Human ADP-ribosylation factor 1
    Protein for Human ADP-ribosylation factor 1
    Protein for Human ADP-ribosylation factor 1
    Protein for Human ADP-ribosylation factor 1
    Protein for Human ADP-ribosylation factor 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin."
      Bobak D.A. , Nightingale M.S. , Murtagh J.J. Jr. , Price S.R. , Moss J. , Vaughan M.
      Proc. Natl. Acad. Sci. U.S.A.86:6101-6105(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins."
      Kahn R.A. , Kern F.G. , Clark J. , Gelmann E.P. , Rulka C.
      J. Biol. Chem.266:2606-2614(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin."
      Lee C.M. , Haun R.S. , Tsai S.C. , Moss J. , Vaughan M.
      J. Biol. Chem.267:9028-9034(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
      Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cervix.
      tissue: Eye.
      tissue: Kidney.
    9. 9.
      Lubec G. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-30; 80-97 AND 118-142;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Fetal brain cortex.
    10. 10.
      "p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins."
      Rosa J.L. , Casaroli-Marano R.P. , Buckler A.J. , Vilaro S. , Barbacid M.
      EMBO J.15:4262-4273(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HERC1
    11. 11.
      "Identification of a new Pyk2 target protein with Arf-GAP activity."
      Andreev J. , Simon J.-P. , Sabatini D.D. , Kam J. , Plowman G. , Randazzo P.A. , Schlessinger J.
      Mol. Cell. Biol.19:2338-2350(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASAP2
    12. 12.
      "FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P."
      Godi A. , Di Campli A. , Konstantakopoulos A. , Di Tullio G. , Alessi D.R. , Kular G.S. , Daniele T. , Marra P. , Lucocq J.M. , De Matteis M.A.
      Nat. Cell Biol.6:393-404(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLEKHA8
    13. 13.
      "Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes."
      Menetrey J. , Perderiset M. , Cicolari J. , Dubois T. , Elkhatib N. , El Khadali F. , Franco M. , Chavrier P. , Houdusse A.
      EMBO J.26:1953-1962(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGAP21
    14. 14.
      "Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta."
      Haynes L.P. , Sherwood M.W. , Dolman N.J. , Burgoyne R.D.
      Traffic8:1080-1092(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PI4KB AND NCS1;SUBCELLULAR LOCATION
    15. 15.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    16. 16.
      "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
      Suzuki T. , Moriya K. , Nagatoshi K. , Ota Y. , Ezure T. , Ando E. , Tsunasawa S. , Utsumi T.
      Proteomics10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MYRISTOYLATION AT GLY-2
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain."
      He J. , Scott J.L. , Heroux A. , Roy S. , Lenoir M. , Overduin M. , Stahelin R.V. , Kutateladze T.G.
      J. Biol. Chem.286:18650-18657(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLEKHA3
    19. 19.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ."
      Burnaevskiy N. , Fox T.G. , Plymire D.A. , Ertelt J.M. , Weigele B.A. , Selyunin A.S. , Way S.S. , Patrie S.M. , Alto N.M.
      Nature496:106-109(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MYRISTOYLATION AT GLY-2;DEMYRISTOYLATION
    21. 21.
      "The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity."
      Rocca D.L. , Amici M. , Antoniou A. , Suarez E.B. , Halemani N. , Murk K. , McGarvey J. , Jaafari N. , Mellor J.R. , Collingridge G.L. , Hanley J.G.
      Neuron79:293-307(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PICK1 AND GRIA2
    22. 22.
      "Structure of the human ADP-ribosylation factor 1 complexed with GDP."
      Amor J.C. , Harrison D.H. , Kahn R.A. , Ringe D.
      Nature372:704-708(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
    23. 23.
      "Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis."
      Goldberg J.
      Cell96:893-902(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH RAT ARFGAP1 CATALYTIC DOMAIN
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