Gene name:
ARFGAP1 (ARF1GAP) ;
Protein name:
ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) ;
Alternative:
ARF1-directed GTPase-activating protein ;ADP-ribosylation factor 1 GTPase-activating protein (ARF1 GAP) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and RNP24. The interaction with RNP24 inhibits the GAP activity.
Function:
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and RNP24. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.
Subcellular Location:
Cytoplasm
Golgi apparatus
Associates with the Golgi complex.
Protein Attributes:
50:
MASPRTRKVL | KEVRVQDENN | VCFECGAFNP | QWVSVTYGIW | ICLECSGRHR |
100:
GLGVHLSFVR | SVTMDKWKDI | ELEKMKAGGN | AKFREFLESQ | EDYDPCWSLQ |
150:
EKYNSRAAAL | FRDKVVALAE | GREWSLESSP | AQNWTPPQPR | TLPSMVHRVS |
200:
GQPQSVTASS | DKAFEDWLND | DLGSYQGAQG | NRYVGFGNTP | PPQKKEDDFL |
250:
NNAMSSLYSG | WSSFTTGASR | FASAAKEGAT | KFGSQASQKA | SELGHSLNEN |
300:
VLKPAQEKVK | EGKIFDDVSS | GVSQLASKVQ | GVGSKGWRDV | TTFFSGKAEG |
350:
PLDSPSEGHS | YQNSGLDHFQ | NSNIDQSFWE | TFGSAEPTKT | RKSPSSDSWT |
400:
CADTSTERRS | SDSWEVWGSA | STNRNSNSDG | GEGGEGTKKA | VPPAVPTDDG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human ARF GAP 1
ELISA Kit for Human ARF GAP 1
ELISA Kit for Human ARF GAP 1
CLIA Kit for Human ARF GAP 1
CLIA Kit for Human ARF GAP 1
CLIA Kit for Human ARF GAP 1
Polyclonal Antibody for Human ARF GAP 1
Polyclonal Antibody for Human ARF GAP 1
Polyclonal Antibody for Human ARF GAP 1
Monoclonal Antibody for Human ARF GAP 1
Monoclonal Antibody for Human ARF GAP 1
Monoclonal Antibody for Human ARF GAP 1
Protein for Human ARF GAP 1
Protein for Human ARF GAP 1
Protein for Human ARF GAP 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5)
tissue :
Thymus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Fetal brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-135 AND SER-304;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-189;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-231;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-135 AND THR-189;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-128 IN COMPLEX WITH ZINC IONS