Arhgef28 ELISA Kit for Mouse(Mus musculus) | EIAab.comArhgef28 ELISA Kit for Mouse(Mus musculus)

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Arhgef28 (Gene name),

Rho guanine nucleotide exchange factor 28 (Protein name ), ARG28_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Arhgef28(Kiaa1998;Rgnef;Rhoip2;Rip2);

Protein name:

Rho guanine nucleotide exchange factor 28;

Alternative:

Rho guanine nucleotide exchange factor;190 kDa guanine nucleotide exchange factor(p190-RhoGEF);Rho-interacting protein 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homooligomer; forms some cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL. Interacts with CTNND2; prevents interaction with RHOA.

Function:

Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.

Subcellular Location:

Cytoplasm Cell membrane Colocalizes with the microtubule radial and cortical systems.

Protein Attributes:

Sequence length:

1693

Sequence:

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1693:

FQSESSSPQD | SNQRWPPATD | THNRSKTKSS | DGGWTRWRCW | RRG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000105053

KEGG:

mmu:110596

UniGene:

Mm.252718

SMR:

P97433

Pfam:

PF00130

Uniprot:

P97433

FOR

ELISA Kit for Mouse Rho guanine nucleotide exchange factor 28

CLIA Kit for Mouse Rho guanine nucleotide exchange factor 28

Polyclonal Antibody for Mouse Rho guanine nucleotide exchange factor 28

Monoclonal Antibody for Mouse Rho guanine nucleotide exchange factor 28

Protein for Mouse Rho guanine nucleotide exchange factor 28

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology."
Gebbink M.F.B.G. , Kranenburg O. , Poland M. , van Horck F.P.G. , Houssa B. , Moolenaar W.H.
J. Cell Biol.137:1603-1613(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
tissue: Brain.
2.

"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Seino S. , Nishimura M. , Kaisho T. , Hoshino K. , Kitamura H. , Nagase T. , Ohara O. , Koga H.
DNA Res.11:205-218(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-649 (ISOFORM 1)
strain: FVB/N-3.
tissue: Bone.
tissue: Mammary tumor.
4.

"Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons."
Meyer D. , Liu A. , Margolis B.
J. Biol. Chem.274:35113-35118(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK8IP1;MUTAGENESIS OF PHE-1563; ASN-1565 AND PHE-1568
5.

"Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules."
van Horck F.P.G. , Ahmadian M.R. , Haeusler L.C. , Moolenaar W.H. , Kranenburg O.
J. Biol. Chem.276:4948-4956(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RHOA AND MICROTUBULES;MUTAGENESIS OF TYR-1003;SUBCELLULAR LOCATION
6.

"p190RhoGEF Binds to a destabilizing element in the 3' untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript."
Canete-Soler R. , Wu J. , Zhai J. , Shamim M. , Schlaepfer W.W.
J. Biol. Chem.276:32046-32050(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEFL EXPRESSION;NEFL RNA-BINDING
7.

"Identification of a novel interaction of 14-3-3 with p190RhoGEF."
Zhai J. , Lin H. , Shamim M. , Schlaepfer W.W. , Canete-Soler R.
J. Biol. Chem.276:41318-41324(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH YWHAE AND YWHAH;MUTAGENESIS OF ASN-1375 AND LEU-1376
8.

"Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein."
Wu J. , Zhai J. , Lin H. , Nie Z. , Ge W.-W. , Garcia-Bermejo L. , Muschel R.J. , Schlaepfer W.W. , Canete-Soler R.
Brain Res. Mol. Brain Res.117:27-38(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;OLIGOMERIZATION;IDENTIFICATION IN A COMPLEX WITH MAPK8 AND MAPK8IP1
9.

"Direct interaction of focal adhesion kinase with p190RhoGEF."
Zhai J. , Lin H. , Nie Z. , Wu J. , Canete-Soler R. , Schlaepfer W.W. , Schlaepfer D.D.
J. Biol. Chem.278:24865-24873(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PTK2/FAK1;PHOSPHORYLATION;TISSUE SPECIFICITY
10.

"Induced expression of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, following CD40 stimulation and WEHI 231 B cell activation."
Lee J.R. , Ha Y.J. , Kim H.J.
J. Immunol.170:19-23(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION;INDUCTION
11.

"Control of axonal branching and synapse formation by focal adhesion kinase."
Rico B. , Beggs H.E. , Schahin-Reed D. , Kimes N. , Schmidt A. , Reichardt L.F.
Nat. Neurosci.7:1059-1069(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AXONAL BRANCHING AND SYNAPSE FORMATION
12.

"RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration."
Lin H. , Zhai J. , Schlaepfer W.W.
Hum. Mol. Genet.14:3643-3659(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NEFL
13.

"Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation."
Kim H. , Han J.-R. , Park J. , Oh M. , James S.E. , Chang S. , Lu Q. , Lee K.Y. , Ki H. , Song W.-J. , Kim K.
J. Biol. Chem.283:977-987(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CTNND2
14.

"PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility."
Lim Y. , Lim S.-T. , Tomar A. , Gardel M. , Bernard-Trifilo J.A. , Chen X.L. , Uryu S.A. , Canete-Soler R. , Zhai J. , Lin H. , Schlaepfer W.W. , Nalbant P. , Bokoch G. , Ilic D. , Waterman-Storer C. , Schlaepfer D.D.
J. Cell Biol.180:187-203(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY PTK2B/PYK2

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