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Index > Protein center > Arhgef28(Gene name) > Rat
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  • Arhgef28 (Gene name),
  • Rho guanine nucleotide exchange factor 28 (Protein name ),  ARG28_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Arhgef28(Rgnef);
    Protein name:
    Rho guanine nucleotide exchange factor 28;
    Alternative:
    Rho guanine nucleotide exchange factor;190 kDa guanine nucleotide exchange factor(p190-RhoGEF);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL. Interacts with CTNND2; prevents interaction with RHOA.
    Function:
    Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
    Subcellular Location:
    Cytoplasm Cell membrane Colocalizes with the microtubule radial and cortical systems.
    Protein Attributes:
    Sequence length:
    1700
    Sequence:
    50:
    MELSCSEVPL | YGQRTVYAKF | GKNVYLPEDA | EFYFIYDGSH | QRHVVIADRV | 
    100:
    EDNVLQSIIP | GHWLQETVMV | SVCLCSEGYS | PVTMGSGSVT | YVDNMACRLA | 
    150:
    RLLVTQADRL | TPCSHQTLLT | PFALTAEALP | ALDEELVLAL | TQLELPLGWT | 
    200:
    VLGNSSLEVC | LHRESLLHLA | VRWALPKLFH | FLLCLPGGVK | ALELPNEEAT | 
    250:
    TPLDLALHGG | HSMLVEDISN | FQGRRSPGFS | RLRLNEDATL | QFDRSSETLT | 
    300:
    LTVNHTAEHL | LEADIKLFRK | YFWDRAFLVK | ALDQEAKTER | ATMPSGAAET | 
    350:
    EEEVRNLESG | RSPSEEEEDG | QLVKSQADGP | SEQEDQDRLV | LDHSFDGLKK | 
    400:
    SKHAPASLAA | GQLSDVPNGG | DEVYANCMVI | DQVGDLDINY | INIEGLSTHT | 
    450:
    SPESMRSTLG | PQACKHILPP | DTSPCGHLLC | EDSDRTLDAA | ASQSCMSPPS | 
    500:
    SHTSNLNLSF | GLHGFVKEQS | HLKKRSSSLD | ALVADSEEEG | RSEPPICYAV | 
    550:
    GSQSSPRTGL | PGGDELDSFD | ANTEPDCNIS | RTESLSLSST | LHSKESLLSG | 
    600:
    IRSRSYSCSS | PKISSGKSRL | VRDFTVCSSS | EEQRSYSFQE | PPGEKRIQEE | 
    650:
    EWDDYIIPAK | AESEKHKVSR | TFSFLMNRMT | SPRNKSKMKN | KDTKDKEKLN | 
    700:
    RHQFVPGTFS | GVLQCSGCDK | TLLGKESLQC | ANCKANTHKG | CKDTVPPCTK | 
    750:
    KFQDKYNKNK | PQTILGSSSV | RDVPPPGLSL | HPSPSMPIGL | PAGRKETAGQ | 
    800:
    AHPLSRSVPG | TTLESFRRAV | TSLESEGDSN | SWRSRSHSDE | LFQSMGSSPS | 
    850:
    TESFMMEDVV | DSSLWSELSS | DAQEFEAESW | SLVVDPSFCS | RQEKDVIKRQ | 
    900:
    DVIFELMQTE | VHHIQTLLIM | SEVFRKGMKE | ELQLDHSTVD | RIFPCLDELL | 
    950:
    ETHKHFFFSM | KERRQESCTG | NDRNFVINQI | GDILVQQFSE | ENASKMKRIY | 
    1000:
    GDFCSHHKEA | MSLFKELQQN | KKFQNFIKIR | NSNLLARRRG | IPECILLVTQ | 
    1050:
    RITKYPVLVE | RILQYTKERT | EEHRDLCRAL | GLIKDMIAAV | DLKVSEYEKN | 
    1100:
    QKWLEILNKI | ENKTYTKLKN | GHVFRKQALM | SQERALLHDG | LVYWKTATGR | 
    1150:
    FKDILALLLT | DVLLFLQEKD | QKYIFAAVDQ | KPSVISLQKL | IAREVANEER | 
    1200:
    GMFLISASSA | GPEMYEIHTS | SKEERNNWMR | RIQQAVESCP | EEEGGRTSES | 
    1250:
    DEERRKADAR | VAKIQQCQEI | LSNQDQQICT | YLEEKLHIYA | ELGELSGFED | 
    1300:
    VHLEPHLLIK | PDPGEPPQAA | SLLAAALREA | ESLQVAVKAS | KLADVSQPSE | 
    1350:
    EGPGGAVLAD | TLSAQDAPAS | PTAFTEGTEG | RGCWDVDPRL | QGVVTDLAVS | 
    1400:
    DAGEKVEYRS | FSGSSQSEII | QAIQNLTRLL | YSLQAALTIQ | DSHIEIHKLV | 
    1450:
    LQQQESLAPS | HSFRGGPLQD | QEKSRYLEKH | REELANIHKL | QYQFQQEQRR | 
    1500:
    WHRTCDQQQR | EQEAQESWLQ | ARERECQSQE | ELLLRHRSEL | DHQLQEYQQN | 
    1550:
    LERLREGQRM | VERERQRMRD | QQGLLGHCKH | SRQRSLPAVF | SPGSKEVTEL | 
    1600:
    NRAESLCHEK | SFFLNDAFTH | MSLNTSNKPN | PSGAPWDAHP | PGGSHLDLAR | 
    1650:
    TSDSQIEVKM | DVSQPSDVNS | ELWTTGLGPQ | RPARQESIKD | SCKNVADLNS | 
    1700:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Rho guanine nucleotide exchange factor 28
    ELISA Kit for Rat Rho guanine nucleotide exchange factor 28
    ELISA Kit for Rat Rho guanine nucleotide exchange factor 28
    CLIA Kit for Rat Rho guanine nucleotide exchange factor 28
    CLIA Kit for Rat Rho guanine nucleotide exchange factor 28
    CLIA Kit for Rat Rho guanine nucleotide exchange factor 28
    Polyclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
    Polyclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
    Polyclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
    Monoclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
    Monoclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
    Monoclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
    Protein for Rat Rho guanine nucleotide exchange factor 28
    Protein for Rat Rho guanine nucleotide exchange factor 28
    Protein for Rat Rho guanine nucleotide exchange factor 28

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "p190RhoGEF Binds to a destabilizing element in the 3' untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript."
      Canete-Soler R. , Wu J. , Zhai J. , Shamim M. , Schlaepfer W.W.
      J. Biol. Chem.276:32046-32050(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEFL EXPRESSION;RNA-BINDING
    3. 3.
      "Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA."
      Ge W.-W. , Wu J. , Zhai J. , Nie Z. , Lin H. , Schlaepfer W.W. , Canete-Soler R.
      J. Biol. Chem.277:42701-42705(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;RNA-BINDING
    4. 4.
      "Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein."
      Wu J. , Zhai J. , Lin H. , Nie Z. , Ge W.-W. , Garcia-Bermejo L. , Muschel R.J. , Schlaepfer W.W. , Canete-Soler R.
      Brain Res. Mol. Brain Res.117:27-38(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OLIGOMERIZATION;IDENTIFICATION IN A COMPLEX WITH MAPK8 AND MAPK8IP1
    5. 5.
      "Direct interaction of focal adhesion kinase with p190RhoGEF."
      Zhai J. , Lin H. , Nie Z. , Wu J. , Canete-Soler R. , Schlaepfer W.W. , Schlaepfer D.D.
      J. Biol. Chem.278:24865-24873(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTK2/FAK1
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