Gene name:
Arhgef28 (Rgnef) ;
Protein name:
Rho guanine nucleotide exchange factor 28 ;
Alternative:
Rho guanine nucleotide exchange factor ;190 kDa guanine nucleotide exchange factor (p190-RhoGEF) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL. Interacts with CTNND2; prevents interaction with RHOA.
Function:
Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
Subcellular Location:
Cytoplasm
Cell membrane
Colocalizes with the microtubule radial and cortical systems.
Protein Attributes:
50:
MELSCSEVPL | YGQRTVYAKF | GKNVYLPEDA | EFYFIYDGSH | QRHVVIADRV |
100:
EDNVLQSIIP | GHWLQETVMV | SVCLCSEGYS | PVTMGSGSVT | YVDNMACRLA |
150:
RLLVTQADRL | TPCSHQTLLT | PFALTAEALP | ALDEELVLAL | TQLELPLGWT |
200:
VLGNSSLEVC | LHRESLLHLA | VRWALPKLFH | FLLCLPGGVK | ALELPNEEAT |
250:
TPLDLALHGG | HSMLVEDISN | FQGRRSPGFS | RLRLNEDATL | QFDRSSETLT |
300:
LTVNHTAEHL | LEADIKLFRK | YFWDRAFLVK | ALDQEAKTER | ATMPSGAAET |
350:
EEEVRNLESG | RSPSEEEEDG | QLVKSQADGP | SEQEDQDRLV | LDHSFDGLKK |
400:
SKHAPASLAA | GQLSDVPNGG | DEVYANCMVI | DQVGDLDINY | INIEGLSTHT |
450:
SPESMRSTLG | PQACKHILPP | DTSPCGHLLC | EDSDRTLDAA | ASQSCMSPPS |
500:
SHTSNLNLSF | GLHGFVKEQS | HLKKRSSSLD | ALVADSEEEG | RSEPPICYAV |
550:
GSQSSPRTGL | PGGDELDSFD | ANTEPDCNIS | RTESLSLSST | LHSKESLLSG |
600:
IRSRSYSCSS | PKISSGKSRL | VRDFTVCSSS | EEQRSYSFQE | PPGEKRIQEE |
650:
EWDDYIIPAK | AESEKHKVSR | TFSFLMNRMT | SPRNKSKMKN | KDTKDKEKLN |
700:
RHQFVPGTFS | GVLQCSGCDK | TLLGKESLQC | ANCKANTHKG | CKDTVPPCTK |
750:
KFQDKYNKNK | PQTILGSSSV | RDVPPPGLSL | HPSPSMPIGL | PAGRKETAGQ |
800:
AHPLSRSVPG | TTLESFRRAV | TSLESEGDSN | SWRSRSHSDE | LFQSMGSSPS |
850:
TESFMMEDVV | DSSLWSELSS | DAQEFEAESW | SLVVDPSFCS | RQEKDVIKRQ |
900:
DVIFELMQTE | VHHIQTLLIM | SEVFRKGMKE | ELQLDHSTVD | RIFPCLDELL |
950:
ETHKHFFFSM | KERRQESCTG | NDRNFVINQI | GDILVQQFSE | ENASKMKRIY |
1000:
GDFCSHHKEA | MSLFKELQQN | KKFQNFIKIR | NSNLLARRRG | IPECILLVTQ |
1050:
RITKYPVLVE | RILQYTKERT | EEHRDLCRAL | GLIKDMIAAV | DLKVSEYEKN |
1100:
QKWLEILNKI | ENKTYTKLKN | GHVFRKQALM | SQERALLHDG | LVYWKTATGR |
1150:
FKDILALLLT | DVLLFLQEKD | QKYIFAAVDQ | KPSVISLQKL | IAREVANEER |
1200:
GMFLISASSA | GPEMYEIHTS | SKEERNNWMR | RIQQAVESCP | EEEGGRTSES |
1250:
DEERRKADAR | VAKIQQCQEI | LSNQDQQICT | YLEEKLHIYA | ELGELSGFED |
1300:
VHLEPHLLIK | PDPGEPPQAA | SLLAAALREA | ESLQVAVKAS | KLADVSQPSE |
1350:
EGPGGAVLAD | TLSAQDAPAS | PTAFTEGTEG | RGCWDVDPRL | QGVVTDLAVS |
1400:
DAGEKVEYRS | FSGSSQSEII | QAIQNLTRLL | YSLQAALTIQ | DSHIEIHKLV |
1450:
LQQQESLAPS | HSFRGGPLQD | QEKSRYLEKH | REELANIHKL | QYQFQQEQRR |
1500:
WHRTCDQQQR | EQEAQESWLQ | ARERECQSQE | ELLLRHRSEL | DHQLQEYQQN |
1550:
LERLREGQRM | VERERQRMRD | QQGLLGHCKH | SRQRSLPAVF | SPGSKEVTEL |
1600:
NRAESLCHEK | SFFLNDAFTH | MSLNTSNKPN | PSGAPWDAHP | PGGSHLDLAR |
1650:
TSDSQIEVKM | DVSQPSDVNS | ELWTTGLGPQ | RPARQESIKD | SCKNVADLNS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat Rho guanine nucleotide exchange factor 28
ELISA Kit for Rat Rho guanine nucleotide exchange factor 28
ELISA Kit for Rat Rho guanine nucleotide exchange factor 28
CLIA Kit for Rat Rho guanine nucleotide exchange factor 28
CLIA Kit for Rat Rho guanine nucleotide exchange factor 28
CLIA Kit for Rat Rho guanine nucleotide exchange factor 28
Polyclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
Polyclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
Polyclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
Monoclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
Monoclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
Monoclonal Antibody for Rat Rho guanine nucleotide exchange factor 28
Protein for Rat Rho guanine nucleotide exchange factor 28
Protein for Rat Rho guanine nucleotide exchange factor 28
Protein for Rat Rho guanine nucleotide exchange factor 28
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN NEFL EXPRESSION;RNA-BINDING
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;RNA-BINDING
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : OLIGOMERIZATION;IDENTIFICATION IN A COMPLEX WITH MAPK8 AND MAPK8IP1
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PTK2/FAK1