Interacts with 14-3-3 zeta; when phosphorylated at Ser-886. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1. Interacts (via the N-terminal zinc finger) with CAPN6 (via domain II).
Function:
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA.
Subcellular Location:
Cytoplasm
Cell junction
tight junction
Golgi apparatus
Cytoplasm
cytoskeleton
spindle
Cell projection
ruffle membrane
Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH RHOA AND RAC1
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);MUTAGENESIS OF CYS-53 AND TYR-394
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-986 (ISOFORMS 1/3)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 630-986 (ISOFORMS 1/2/3)
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Cited for: PHOSPHORYLATION AT SER-886;INTERACTION WITH YWHAZ
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Cited for: PHOSPHORYLATION AT SER-143 AND SER-896;MUTAGENESIS OF SER-143 AND SER-896;SUBCELLULAR LOCATION;INTERACTION WITH PAK4
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-932;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION AT SER-886 AND SER-960;INTERACTION WITH AURKA;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION AT THR-679;INTERACTION WITH MAPK1;MUTAGENESIS OF THR-679
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH NOD1
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163; SER-645; SER-648; SER-696; SER-886; TYR-894; SER-940; SER-941; SER-956 AND SER-960;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172; THR-679; SER-691; SER-696; SER-886; SER-941; THR-945; SER-947; SER-953; SER-956 AND SER-960;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-353;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-932; SER-956 AND SER-960;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH NOD2 AND RIPK2;INTERACTION WITH RIPK1; RIPK2 AND RIPK3;SUBCELLULAR LOCATION;INDUCTION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Vaild Sequence:
