ARHGEF2 ELISA Kit for Pig(Sus scrofa) | EIAab.comARHGEF2 ELISA Kit for Pig(Sus scrofa)

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ARHGEF2 (Gene name),

Rho guanine nucleotide exchange factor 2 (Protein name ), ARHG2_PIG from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ARHGEF2;

Protein name:

Rho guanine nucleotide exchange factor 2;

Alternative:

Guanine nucleotide exchange factor H1(GEF-H1);

Organism:

Pig (Sus scrofa).

General Annotation

Sub Unit:

Interacts with 14-3-3 zeta; when phosphorylated at Ser-860. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1 (By similarity). Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II).

Function:

Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens.

Subcellular Location:

Cytoplasm Cell junction tight junction Golgi apparatus Cytoplasm cytoskeleton spindle Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization.

Protein Attributes:

Sequence length:

961

Sequence:

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961:

SRDGEPVASE | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9823.ENSSSCP00000006930

Pfam:

PF00169

UniGene:

Ssc.8984

KEGG:

ssc:100145887

String:

B2DCZ9

Uniprot:

B2DCZ9

FOR

ELISA Kit for Pig Rho guanine nucleotide exchange factor 2

CLIA Kit for Pig Rho guanine nucleotide exchange factor 2

Polyclonal Antibody for Pig Rho guanine nucleotide exchange factor 2

Monoclonal Antibody for Pig Rho guanine nucleotide exchange factor 2

Protein for Pig Rho guanine nucleotide exchange factor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of down-regulated genes in pig mesenteric adipocyte differentiation."
Suzuki S.
Submitted (2007-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?"
Birkenfeld J. , Nalbant P. , Yoon S.-H. , Bokoch G.M.
Trends Cell Biol.18:210-219(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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