ARHGEF4 ELISA Kit for Human(Homo sapiens) | EIAab.comARHGEF4 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > ARHGEF4(Gene name) > Human

ARHGEF4 (Gene name),

Rho guanine nucleotide exchange factor 4 (Protein name ), ARHG4_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

ARHGEF4(KIAA1112);

Protein name:

Rho guanine nucleotide exchange factor 4;

Alternative:

APC-stimulated guanine nucleotide exchange factor 1(Asef;Asef1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Isoform 3 interacts with RHOA and RAC1, and (via ABR domain) with APC. Found in a complex consisting of ARHGEF4, APC and CTNNB1.

Function:

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Subcellular Location:

Isoform 3 Cytoplasm Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Associated with membrane ruffles.

Protein Attributes:

Sequence length:

690

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

690:

QKHPALPSNR | PQQQVLVLAE | PRRKPSTFWH | SISRLAPFRK |

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

Q9NR80

KEGG:

hsa:50649

Pfam:

PF00169

STRING:

9606.ENSP00000316845

SMR:

Q9NR80

UniGene:

Hs.469935

MIM:

605216

Uniprot:

Q9NR80

FOR

ELISA Kit for Human Rho guanine nucleotide exchange factor 4

CLIA Kit for Human Rho guanine nucleotide exchange factor 4

Polyclonal Antibody for Human Rho guanine nucleotide exchange factor 4

Monoclonal Antibody for Human Rho guanine nucleotide exchange factor 4

Protein for Human Rho guanine nucleotide exchange factor 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22."
Thiesen S. , Kuebart S. , Ropers H.-H. , Nothwang H.G.
Biochem. Biophys. Res. Commun.273:364-369(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
2.

"Asef, a link between the tumor suppressor APC and G-protein signaling."
Kawasaki Y. , Senda T. , Ishidate T. , Koyama R. , Morishita T. , Iwayama Y. , Higuchi O. , Akiyama T.
Science289:1194-1197(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH APC; RHOA AND RAC1;IDENTIFICATION IN A COMPLEX WITH APC AND CTNNB1
tissue: Fetal brain.
3.

"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R. , Nagase T. , Ishikawa K. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.6:197-205(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Brain.
4.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
5.

"Mutated APC and Asef are involved in the migration of colorectal tumour cells."
Kawasaki Y. , Sato R. , Akiyama T.
Nat. Cell Biol.5:211-215(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element."
Hamann M.J. , Lubking C.M. , Luchini D.N. , Billadeau D.D.
Mol. Cell. Biol.27:1380-1393(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
7.

"Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42."
Kawasaki Y. , Sagara M. , Shibata Y. , Shirouzu M. , Yokoyama S. , Akiyama T.
Oncogene26:7620-7627(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."
Kawasaki Y. , Tsuji S. , Muroya K. , Furukawa S. , Shibata Y. , Okuno M. , Ohwada S. , Akiyama T.
EMBO Rep.10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
9.

"Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism."
Murayama K. , Shirouzu M. , Kawasaki Y. , Kato-Murayama M. , Hanawa-Suetsugu K. , Sakamoto A. , Katsura Y. , Suenaga A. , Toyama M. , Terada T. , Taiji M. , Akiyama T. , Yokoyama S.
J. Biol. Chem.282:4238-4242(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.36 ANGSTROMS) OF 143-611;SH3 DOMAIN
10.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-100 AND ARG-441

Product Feedback Wall

* Email:
*Comments: