Arhgef4 ELISA Kit for Mouse(Mus musculus) | EIAab.comArhgef4 ELISA Kit for Mouse(Mus musculus)

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Arhgef4 (Gene name),

Rho guanine nucleotide exchange factor 4 (Protein name ), ARHG4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Arhgef4(Kiaa1112);

Protein name:

Rho guanine nucleotide exchange factor 4;

Alternative:

APC-stimulated guanine nucleotide exchange factor(Asef);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with RHOA and RAC1, and APC. Found in a complex consisting of ARHGEF4, APC and CTNNB1.

Function:

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Subcellular Location:

Cytoplasm Colocalized with APC in the synapse of olfactory glomerulus.

Protein Attributes:

Sequence length:

484

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

484:

PASRPQQQVL | VLAEPRRKPS | NFWHSISRLA | PFRK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q7TNR9

UniGene:

Mm.41604

SMR:

Q7TNR9

Pfam:

PF00169

KEGG:

mmu:226970

Uniprot:

Q7TNR9

FOR

ELISA Kit for Mouse Rho guanine nucleotide exchange factor 4

CLIA Kit for Mouse Rho guanine nucleotide exchange factor 4

Polyclonal Antibody for Mouse Rho guanine nucleotide exchange factor 4

Monoclonal Antibody for Mouse Rho guanine nucleotide exchange factor 4

Protein for Mouse Rho guanine nucleotide exchange factor 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
3.

"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-484
tissue: Brain.
4.

Okazaki N. , Kikuno R. , Nagase T. , Ohara O. , Koga H.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
5.

"Asef, a link between the tumor suppressor APC and G-protein signaling."
Kawasaki Y. , Senda T. , Ishidate T. , Koyama R. , Morishita T. , Iwayama Y. , Higuchi O. , Akiyama T.
Science289:1194-1197(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."
Kawasaki Y. , Tsuji S. , Muroya K. , Furukawa S. , Shibata Y. , Okuno M. , Ohwada S. , Akiyama T.
EMBO Rep.10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY

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