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Index > Protein center > ARHGEF6(Gene name) > Human
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  • ARHGEF6 (Gene name),
  • Rho guanine nucleotide exchange factor 6 (Protein name ),  ARHG6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ARHGEF6(COOL2;KIAA0006;PIXA);
    Protein name:
    Rho guanine nucleotide exchange factor 6;
    Alternative:
    COOL-2;Alpha-Pix;Rac/Cdc42 guanine nucleotide exchange factor 6;PAK-interacting exchange factor alpha;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1.
    Function:
    Acts as a RAC1 guanine nucleotide exchange factor (GEF).
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    776
    Sequence:
    50:
    MNPEEQIVTW | LISLGVLESP | KKTICDPEEF | LKSSLKNGVV | LCKLINRLMP | 
    100:
    GSVEKFCLDP | QTEADCINNI | NDFLKGCATL | QVEIFDPDDL | YSGVNFSKVL | 
    150:
    STLLAVNKAT | EDQLSERPCG | RSSSLSAANT | SQTNPQGAVS | STVSGLQRQS | 
    200:
    KTVEMTENGS | HQLIVKARFN | FKQTNEDELS | VCKGDIIYVT | RVEEGGWWEG | 
    250:
    TLNGRTGWFP | SNYVREIKSS | ERPLSPKAVK | GFETAPLTKN | YYTVVLQNIL | 
    300:
    DTEKEYAKEL | QSLLVTYLRP | LQSNNNLSTV | EVTSLLGNFE | EVCTFQQTLC | 
    350:
    QALEECSKFP | ENQHKVGGCL | LSLMPHFKSM | YLAYCANHPS | AVNVLTQHSD | 
    400:
    ELEQFMENQG | ASSPGILILT | TNLSKPFMRL | EKYVTLLQEL | ERHMEDTHPD | 
    450:
    HQDILKAIVA | FKTLMGQCQD | LRKRKQLELQ | ILSEPIQAWE | GEDIKNLGNV | 
    500:
    IFMSQVMVQY | GACEEKEERY | LMLFSNVLIM | LSASPRMSGF | IYQGKIPIAG | 
    550:
    TVVTRLDEIE | GNDCTFEITG | NTVERIVVHC | NNNQDFQEWL | EQLNRLIRGP | 
    600:
    ASCSSLSKTS | SSSCSAHSSF | SSTGQPRGPL | EPPQIIKPWS | LSCLRPAPPL | 
    650:
    RPSAALGYKE | RMSYILKESS | KSPKTMKKFL | HKRKTERKPS | EEEYVIRKST | 
    700:
    AALEEDAQIL | KVIEAYCTSA | NFQQGHGSST | RKDSIPQVLL | PEEEKLIIEE | 
    750:
    TRSNGQTIME | EKSLVDTVYA | LKDEVRELKQ | ENKRMKQCLE | EELKSRRDLE | 
    776:
    KLVRRLLKQT | DECIRGESSS | KTSILP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Rho guanine nucleotide exchange factor 6
    ELISA Kit for Human Rho guanine nucleotide exchange factor 6
    ELISA Kit for Human Rho guanine nucleotide exchange factor 6
    ELISA Kit for Human Rho guanine nucleotide exchange factor 6
    CLIA Kit for Human Rho guanine nucleotide exchange factor 6
    CLIA Kit for Human Rho guanine nucleotide exchange factor 6
    CLIA Kit for Human Rho guanine nucleotide exchange factor 6
    CLIA Kit for Human Rho guanine nucleotide exchange factor 6
    Polyclonal Antibody for Human Rho guanine nucleotide exchange factor 6
    Polyclonal Antibody for Human Rho guanine nucleotide exchange factor 6
    Polyclonal Antibody for Human Rho guanine nucleotide exchange factor 6
    Polyclonal Antibody for Human Rho guanine nucleotide exchange factor 6
    Monoclonal Antibody for Human Rho guanine nucleotide exchange factor 6
    Monoclonal Antibody for Human Rho guanine nucleotide exchange factor 6
    Monoclonal Antibody for Human Rho guanine nucleotide exchange factor 6
    Monoclonal Antibody for Human Rho guanine nucleotide exchange factor 6
    Protein for Human Rho guanine nucleotide exchange factor 6
    Protein for Human Rho guanine nucleotide exchange factor 6
    Protein for Human Rho guanine nucleotide exchange factor 6
    Protein for Human Rho guanine nucleotide exchange factor 6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Placenta.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Adipose tissue.
    3. 3.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Testis.
    6. 6.
      "Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation."
      Kutsche K. , Yntema H. , Brandt A. , Jantke I. , Nothwang H.G. , Orth U. , Boavida M.G. , David D. , Chelly J. , Fryns J.-P. , Moraine C. , Ropers H.-H. , Hamel B.C.J. , van Bokhoven H. , Gal A.
      Nat. Genet.26:247-250(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-3 (ISOFORM 1);DISEASE
    7. 7.
      "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N. , Miyajima N. , Sazuka T. , Tanaka A. , Kawarabayasi Y. , Sato S. , Nagase T. , Seki N. , Ishikawa K. , Tabata S.
      DNA Res.1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-776 (ISOFORM 1)
      tissue: Bone marrow.
    8. 8.
      "Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Borjeson-Forssman-Lehmann syndrome and MRX27."
      Lower K.M. , Gecz J.
      Am. J. Med. Genet.100:43-48(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    9. 9.
      "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
      Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor."
      Mishima W. , Suzuki A. , Yamaji S. , Yoshimi R. , Ueda A. , Kaneko T. , Tanaka J. , Miwa Y. , Ohno S. , Ishigatsubo Y.
      Genes Cells9:193-204(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PARVB
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126; SER-144; SER-150; SER-640 AND SER-684;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
      Sanchez-Barrena M.J. , Vallis Y. , Clatworthy M.R. , Doherty G.J. , Veprintsev D.B. , Evans P.R. , McMahon H.T.
      PLoS ONE7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BIN2;IDENTIFICATION IN A COMPLEX WITH BIN2 AND GIT2
    13. 13.
      "Solution structure of the CH domain and the SH3 domain in RAC/CDC42 guanine nucleotide exchange factor (GEF) 6."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2004-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 4-222
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