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Index > Protein center > ARHGEF15(Gene name) > Human
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  • ARHGEF15 (Gene name),
  • Rho guanine nucleotide exchange factor 15 (Protein name ),  ARHGF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ARHGEF15(KIAA0915);
    Protein name:
    Rho guanine nucleotide exchange factor 15;
    Alternative:
    Vsm-RhoGEF;Ephexin-5(E5);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with EPHB2 (By similarity). Interacts with EPHA4.
    Function:
    Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
    Subcellular Location:
    Cell projection dendrite Expressed exclusively in dendrites of the developing hippocampus.
    Protein Attributes:
    Sequence length:
    841
    Sequence:
    50:
    MSAQSLPAAT | PPTQKPPRII | RPRPPSRSRA | AQSPGPPHNG | SSPQELPRNS | 
    100:
    NDAPTPMCTP | IFWEPPAASL | KPPALLPPSA | SRASLDSQTS | PDSPSSTPTP | 
    150:
    SPVSRRSASP | EPAPRSPVPP | PKPSGSPCTP | LLPMAGVLAQ | NGSASAPGTV | 
    200:
    RRLAGRFEGG | AEGRAQDADA | PEPGLQARAD | VNGEREAPLT | GSGSQENGAP | 
    250:
    DAGLACPPCC | PCVCHTTRPG | LELRWVPVGG | YEEVPRVPRR | ASPLRTSRSR | 
    300:
    PHPPSIGHPA | VVLTSYRSTA | ERKLLPLLKP | PKPTRVRQDA | TIFGDPPQPD | 
    350:
    LDLLSEDGIQ | TGDSPDEAPQ | NTPPATVEGR | EEEGLEVLKE | QNWELPLQDE | 
    400:
    PLYQTYRAAV | LSEELWGVGE | DGSPSPANAG | DAPTFPRPPG | PRNTLWQELP | 
    450:
    AVQASGLLDT | LSPQERRMQE | SLFEVVTSEA | SYLRSLRLLT | DTFVLSQALR | 
    500:
    DTLTPRDHHT | LFSNVQRVQG | VSERFLATLL | SRVRSSPHIS | DLCDVVHAHA | 
    550:
    VGPFSVYVDY | VRNQQYQEET | YSRLMDTNVR | FSAELRRLQS | LPKCERLPLP | 
    600:
    SFLLLPFQRI | TRLRMLLQNI | LRQTEEGSSR | QENAQKALGA | VSKIIERCSA | 
    650:
    EVGRMKQTEE | LIRLTQRLRF | HKVKALPLVS | WSRRLEFQGE | LTELGCRRGG | 
    700:
    VLFASRPRFT | PLCLLLFSDL | LLITQPKSGQ | RLQVLDYAHR | SLVQAQQVPD | 
    750:
    PSGPPTFRLS | LLSNHQGRPT | HRLLQASSLS | DMQRWLGAFP | TPGPLPCSPD | 
    800:
    TIYEDCDCSQ | ELCSESSAPA | KTEGRSLESR | AAPKHLHKTP | EGWLKGLPGA | 
    841:
    FPAQLVCEVT | GEHERRRHLR | QNQRLLEAVG | SSSGTPNAPP | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    KEGG:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Rho guanine nucleotide exchange factor 15
    ELISA Kit for Human Rho guanine nucleotide exchange factor 15
    CLIA Kit for Human Rho guanine nucleotide exchange factor 15
    CLIA Kit for Human Rho guanine nucleotide exchange factor 15
    Polyclonal Antibody for Human Rho guanine nucleotide exchange factor 15
    Polyclonal Antibody for Human Rho guanine nucleotide exchange factor 15
    Monoclonal Antibody for Human Rho guanine nucleotide exchange factor 15
    Monoclonal Antibody for Human Rho guanine nucleotide exchange factor 15
    Protein for Human Rho guanine nucleotide exchange factor 15
    Protein for Human Rho guanine nucleotide exchange factor 15

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT PRO-831
      tissue: Brain.
    2. 2.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS PRO-277 AND PRO-831
      tissue: Placenta.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS PRO-277 AND PRO-831
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS VAL-155; PRO-277 AND PRO-831
      tissue: Lung.
    6. 7.
      "EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells."
      Ogita H. , Kunimoto S. , Kamioka Y. , Sawa H. , Masuda M. , Mochizuki N.
      Circ. Res.93:23-31(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION;INTERACTION WITH EPHA4;REGULATION
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