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Index > Protein center > ARHGEF26(Gene name) > Human
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  • ARHGEF26 (Gene name),
  • Rho guanine nucleotide exchange factor 26 (Protein name ),  ARHGQ_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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    • Gene name:
    ARHGEF26(HMFN1864;SGEF);
    Protein name:
    Rho guanine nucleotide exchange factor 26;
    Alternative:
    SH3 domain-containing guanine exchange factor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ICAM1 and RHOG.
    Function:
    Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
    Subcellular Location:
    Cell projection ruffle
    Protein Attributes:
    Sequence length:
    871
    Sequence:
    50:
    MDGESEVDFS | SNSITPLWRR | RSIPQPHQVL | GRSKPRPQSY | QSPNGLLITD | 
    100:
    FPVEDGGTLL | AAQIPAQVPT | ASDSRTVHRS | PLLLGAQRRA | VANGGTASPE | 
    150:
    YRAASPRLRR | PKSPKLPKAV | PGGSPKSPAN | GAVTLPAPPP | PPVLRPPRTP | 
    200:
    NAPAPCTPEE | DLTGLTASPV | PSPTANGLAA | NNDSPGSGSQ | SGRKAKDPER | 
    250:
    GLFPGPQKSS | SEQKLPLQRL | PSQENELLEN | PSVVLSTNSP | AALKVGKQQI | 
    300:
    IPKSLASEIK | ISKSNNQNVE | PHKRLLKVRS | MVEGLGGPLG | HAGEESEVDN | 
    350:
    DVDSPGSLRR | GLRSTSYRRA | VVSGFDFDSP | TSSKKKNRMS | QPVLKVVMED | 
    400:
    KEKFSSLGRI | KKKMLKGQGT | FDGEENAVLY | QNYKEKALDI | DSDEESEPKE | 
    450:
    QKSDEKIVIH | HKPLRSTWSQ | LSAVKRKGLS | QTVSQEERKR | QEAIFEVISS | 
    500:
    EHSYLLSLEI | LIRMFKNSKE | LSDTMTKTER | HHLFSNITDV | CEASKKFFIE | 
    550:
    LEARHQNNIF | IDDISDIVEK | HTASTFDPYV | KYCTNEVYQQ | RTLQKLLATN | 
    600:
    PSFKEVLSRI | ESHEDCRNLP | MISFLILPMQ | RVTRLPLLMD | TICQKTPKDS | 
    650:
    PKYEVCKRAL | KEVSKLVRLC | NEGARKMERT | EMMYTINSQL | EFKIKPFPLV | 
    700:
    SSSRWLVKRG | ELTAYVEDTV | LFSRRTSKQQ | VYFFLFNDVL | IITKKKSEES | 
    750:
    YNVNDYSLRD | QLLVESCDNE | ELNSSPGKNS | STMLYSRQSS | ASHLFTLTVL | 
    800:
    SNHANEKVEM | LLGAETQSER | ARWITALGHS | SGKPPADRTS | LTQVEIVRSF | 
    850:
    TAKQPDELSL | QVADVVLIYQ | RVSDGWYEGE | RLRDGERGWF | PMECAKEITC | 
    871:
    QATIDKNVER | MGRLLGLETN | V
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    hsa:26084
    Pfam:
    PF00169
    SMR:
    Q96DR7
    UniGene:
    Hs.240845
    String:
    Q96DR7
    Uniprot:
    Q96DR7
     
    FOR
    ELISA Kit for Human Rho guanine nucleotide exchange factor 26
    CLIA Kit for Human Rho guanine nucleotide exchange factor 26
    Polyclonal Antibody for Human Rho guanine nucleotide exchange factor 26
    Monoclonal Antibody for Human Rho guanine nucleotide exchange factor 26
    Protein for Human Rho guanine nucleotide exchange factor 26

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells."
      Qi H. , Fournier A. , Grenier J. , Fillion C. , Labrie Y. , Labrie C.
      Endocrinology144:1742-1752(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INDUCTION;VARIANT LEU-29
      tissue: Prostatic carcinoma.
    2. 2.
      "SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis."
      Ellerbroek S.M. , Wennerberg K. , Arthur W.T. , Dunty J.M. , Bowman D.R. , DeMali K.A. , Der C. , Burridge K.
      Mol. Biol. Cell15:3309-3319(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH RHOG;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;MUTAGENESIS OF TRP-826;VARIANT LEU-29
      tissue: Brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-871 (ISOFORM 1);VARIANT LEU-29
    4. 4.
      "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S. , Ohira M. , Horie H. , Ando K. , Takayasu H. , Suzuki Y. , Sugano S. , Hirata T. , Goto T. , Matsunaga T. , Hiyama E. , Hayashi Y. , Ando H. , Suita S. , Kaneko M. , Sasaki F. , Hashizume K. , Ohnuma N. , more...
      Oncogene23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS LEU-29; PRO-60 AND SER-203
      tissue: Liver.
    5. 5.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-29
      tissue: Prostate.
      tissue: Testis.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 661-871 (ISOFORM 1)
      tissue: Testis.
    8. 8.
      "Differential activation and function of Rho GTPases during Salmonella-host cell interactions."
      Patel J.C. , Galan J.E.
      J. Cell Biol.175:453-463(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."
      van Buul J.D. , Allingham M.J. , Samson T. , Meller J. , Boulter E. , Garcia-Mata R. , Burridge K.
      J. Cell Biol.178:1279-1293(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ICAM1;SUBCELLULAR LOCATION
    10. 10.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    11. 11.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-392;VARIANT [LARGE SCALE ANALYSIS] LEU-29;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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