Gene name:
ARPIN (C15orf38) ;
Protein name:
Arpin ;
Alternative:
Arp2/3 inhibition protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.
Function:
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
Subcellular Location:
Cell projection
Lamellipodium
Colocalized with the WAVE complex at lamelliupodium tip.
Protein Attributes:
50:
MSRIYHDGAL | RNKAVQSVRL | PGAWDPAAHQ | GGNGVLLEGE | LIDVSRHSIL |
100:
DTHGRKERYY | VLYIRPSHIH | RRKFDAKGNE | IEPNFSATRK | VNTGFLMSSY |
150:
KVEAKGDTDR | LTPEALKGLV | NKPELLALTE | SLTPDHTVAF | WMPESEMEVM |
200:
ELELGAGVRL | KTRGDGPFLD | SLAKLEAGTV | TKCNFTGDGK | TGASWTDNIM |
226:
AQKCSKGAAA | EIREQGDGAE | DEEWDD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Human
ELISA Kit for Human Arpin
ELISA Kit for Human Arpin
ELISA Kit for Human Arpin
Polyclonal Antibody for Human Arpin
Polyclonal Antibody for Human Arpin
Polyclonal Antibody for Human Arpin
Monoclonal Antibody for Human Arpin
Monoclonal Antibody for Human Arpin
Monoclonal Antibody for Human Arpin
R&D Technical Data
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Precision
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Recovery
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Linearity
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