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Index > Protein center > ARPIN(Gene name) > Human
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  • ARPIN (Gene name),
  • Arpin (Protein name ),  ARPIN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    ARPIN(C15orf38);
    Protein name:
    Arpin;
    Alternative:
    Arp2/3 inhibition protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.
    Function:
    Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
    Subcellular Location:
    Cell projection Lamellipodium Colocalized with the WAVE complex at lamelliupodium tip.
    Protein Attributes:
    Sequence length:
    226
    Sequence:
    50:
    MSRIYHDGAL | RNKAVQSVRL | PGAWDPAAHQ | GGNGVLLEGE | LIDVSRHSIL | 
    100:
    DTHGRKERYY | VLYIRPSHIH | RRKFDAKGNE | IEPNFSATRK | VNTGFLMSSY | 
    150:
    KVEAKGDTDR | LTPEALKGLV | NKPELLALTE | SLTPDHTVAF | WMPESEMEVM | 
    200:
    ELELGAGVRL | KTRGDGPFLD | SLAKLEAGTV | TKCNFTGDGK | TGASWTDNIM | 
    226:
    AQKCSKGAAA | EIREQGDGAE | DEEWDD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Arpin
    ELISA Kit for Human Arpin
    ELISA Kit for Human Arpin
    CLIA Kit for Human Arpin
    CLIA Kit for Human Arpin
    CLIA Kit for Human Arpin
    Polyclonal Antibody for Human Arpin
    Polyclonal Antibody for Human Arpin
    Polyclonal Antibody for Human Arpin
    Monoclonal Antibody for Human Arpin
    Monoclonal Antibody for Human Arpin
    Monoclonal Antibody for Human Arpin
    Protein for Human Arpin
    Protein for Human Arpin
    Protein for Human Arpin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C15ORF38-AP3S2)
      tissue: Signet-ring cell carcinoma.
    2. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Fetal brain.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;INTERACTION WITH ARPC2;ASSOCIATION WITH THE ARP2/3 COMPLEX
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