Asah2 ELISA Kit for Mouse(Mus musculus) | EIAab.comAsah2 ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Asah2(Gene name) > Mouse

Asah2 (Gene name),

Neutral ceramidase (Protein name ), ASAH2_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Asah2;

Protein name:

Neutral ceramidase(N-CDase;NCDase);

Alternative:

N-acylsphingosine amidohydrolase 2;Acylsphingosine deacylase 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

N/A

Function:

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.

Subcellular Location:

Cell membrane Single-pass type II membrane protein The neutral ceramidase soluble form is a secreted protein.

Protein Attributes:

Sequence length:

756

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

756:

FEVVTT

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

10090.ENSMUSP00000093830

UniGene:

Mm.104900

Pfam:

PF04734

String:

Q9JHE3

UniGene:

Mm.491229

SMR:

Q9JHE3

KEGG:

mmu:54447

Uniprot:

Q9JHE3

FOR

ELISA Kit for Mouse N-CDase

Cat.:

E11205m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse N-CDase

Cat.:

E11205r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse N-CDase

Cat.:

E11205h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse N-CDase

Cat.:

U11205r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse N-CDase

Cat.:

U11205h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse N-CDase

Cat.:

U11205m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse N-CDase

Cat.:

P11205Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse N-CDase

Cat.:

P11205Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse N-CDase

Cat.:

P11205Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse N-CDase

Protein for Mouse N-CDase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases."
Tani M. , Okino N. , Mori K. , Tanigawa T. , Izu H. , Ito M.
J. Biol. Chem.275:11229-11234(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ENZYME ACTIVITY;TISSUE SPECIFICITY;GLYCOSYLATION
tissue: Brain.
tissue: Liver.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Adipose tissue.
tissue: Corpus striatum.
tissue: Egg.
tissue: Lung.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-756
strain: FVB/N.
tissue: Liver.
4.

"Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized."
Tani M. , Okino N. , Mitsutake S. , Tanigawa T. , Izu H. , Ito M.
J. Biol. Chem.275:3462-3468(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 309-343 AND 592-603;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME ACTIVITY;GLYCOSYLATION
tissue: Liver.
5.

"Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells."
Romiti E. , Meacci E. , Tanzi G. , Becciolini L. , Mitsutake S. , Farnararo M. , Ito M. , Bruni P.
FEBS Lett.506:163-168(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
6.

"Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1."
Romiti E. , Meacci E. , Donati C. , Formigli L. , Zecchi-Orlandini S. , Farnararo M. , Ito M. , Bruni P.
Arch. Biochem. Biophys.417:27-33(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
7.

"Neutral ceramidase gene: role in regulating ceramide-induced apoptosis."
Choi M.S. , Anderson M.A. , Zhang Z. , Zimonjic D.B. , Popescu N. , Mukherjee A.B.
Gene315:113-122(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
8.

"Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu."
Tani M. , Igarashi Y. , Ito M.
J. Biol. Chem.280:36592-36600(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids."
Kono M. , Dreier J.L. , Ellis J.M. , Allende M.L. , Kalkofen D.N. , Sanders K.M. , Bielawski J. , Bielawska A. , Hannun Y.A. , Proia R.L.
J. Biol. Chem.281:7324-7331(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY

Product Feedback Wall

* Email:
*Comments: