ASAP1 ELISA Kit for Human(Homo sapiens) | EIAab.comASAP1 ELISA Kit for Human(Homo sapiens)

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ASAP1 (Gene name),

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (Protein name ), ASAP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ASAP1(DDEF1;KIAA1249);

Protein name:

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1;

Alternative:

ADP-ribosylation factor-directed GTPase-activating protein 1(ARF GTPase-activating protein 1);130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein;PIP2-dependent ARF1 GAP;Development and differentiation-enhancing factor 1(DEF-1;Differentiation-enhancing factor 1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3 (By similarity). Interacts with CTTN. Interacts (via SH3 domain) with APC.

Function:

Possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.

Subcellular Location:

Cytoplasm Membrane Predominantly cytoplasmic (By similarity). Partially membrane-associated.

Protein Attributes:

Sequence length:

1129

Sequence:

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1050:

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1129:

DQEWWIGHIE | GQPERKGVFP | VSFVHILSD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9ULH1

UniGene:

Hs.655552

SMR:

Q9ULH1

Pfam:

PF12796

MIM:

605953

KEGG:

hsa:50807

STRING:

9606.ENSP00000350297

Uniprot:

Q9ULH1

FOR

ELISA Kit for Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

CLIA Kit for Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Polyclonal Antibody for Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Monoclonal Antibody for Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Protein for Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
4.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-1129 (ISOFORM 2)
tissue: Bone marrow.
5.

"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Ishikawa K. , Kikuno R. , Hirosawa M. , Nomura N. , Ohara O.
DNA Res.6:337-345(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 184-1129 (ISOFORM 1)
tissue: Brain.
6.

"ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src."
Brown M.T. , Andrade J. , Radhakrishna H. , Donaldson J.G. , Cooper J.A. , Randazzo P.A.
Mol. Cell. Biol.18:7038-7051(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
7.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1027;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-843 AND SER-1008;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-843 AND SER-1027;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Functional genomic screen for modulators of ciliogenesis and cilium length."
Kim J. , Lee J.E. , Heynen-Genel S. , Suyama E. , Ono K. , Lee K. , Ideker T. , Aza-Blanc P. , Gleeson J.G.
Nature464:1048-1051(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1027;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis."
Hashimoto S. , Hirose M. , Hashimoto A. , Morishige M. , Yamada A. , Hosaka H. , Akagi K. , Ogawa E. , Oneyama C. , Agatsuma T. , Okada M. , Kobayashi H. , Wada H. , Nakano H. , Ikegami T. , Nakagawa A. , Sabe H.
Proc. Natl. Acad. Sci. U.S.A.103:7036-7041(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 823-837 IN COMPLEX WITH CTTN
13.

"Solution structure of the PH domain of PIP2-dependent ARF1 GTPase-activating protein from human."
RIKEN structural genomics initiative (RSGI)
Submitted (2006-06) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 319-428
14.

"Solution structure of the SH3 domain of 130 kDA phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein."
RIKEN structural genomics initiative (RSGI)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1067-1129
15.

"Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain."
Kaieda S. , Matsui C. , Mimori-Kiyosue Y. , Ikegami T.
Biochemistry49:5143-5153(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1069-1129 IN COMPLEX WITH APC;INTERACTION WITH APC

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