Asap1 ELISA Kit for Mouse(Mus musculus) | EIAab.comAsap1 ELISA Kit for Mouse(Mus musculus)

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Asap1 (Gene name),

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (Protein name ), ASAP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Asap1(Ddef1;Kiaa1249;Shag1);

Protein name:

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1;

Alternative:

ADP-ribosylation factor-directed GTPase-activating protein 1(ARF GTPase-activating protein 1);130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein;PIP2-dependent ARF1 GAP;Development and differentiation-enhancing factor 1(DEF-1;Differentiation-enhancing factor 1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3.

Function:

May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity). Posseses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2.

Subcellular Location:

Cytoplasm Membrane Predominantly cytoplasmic. Partially membrane-associated.

Protein Attributes:

Sequence length:

1147

Sequence:

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1050:

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1147:

DDELTFIEGE | VIIVTGEEDQ | EWWIGHIEGQ | PERKGVFPVS | FVHILSD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9QWY8

KEGG:

mmu:13196

Pfam:

PF12796

UniGene:

Mm.277236

String:

Q9QWY8

Uniprot:

Q9QWY8

FOR

ELISA Kit for Mouse Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

CLIA Kit for Mouse Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Polyclonal Antibody for Mouse Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Monoclonal Antibody for Mouse Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Protein for Mouse Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src."
Brown M.T. , Andrade J. , Radhakrishna H. , Donaldson J.G. , Cooper J.A. , Randazzo P.A.
Mol. Cell. Biol.18:7038-7051(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);CHARACTERIZATION;MUTAGENESIS OF ARG-811; PRO-910 AND PRO-913
tissue: Brain.
tissue: Embryo.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-1147 (ISOFORM 4)
strain: C57BL/6.
tissue: Eye.
tissue: Mammary tumor.
4.

"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-1147 (ISOFORM 3)
tissue: Brain.
5.

"Examining the specificity of Src homology 3 domain -- ligand interactions with alkaline phosphatase fusion proteins."
Yamabhai M. , Kay B.K.
Anal. Biochem.247:143-151(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 654-1147 (ISOFORM 1)
6.

"DEF-1, a novel src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines."
King F.J. , Hu E. , Harris D.F. , Sarraf P. , Spiegelman B.M. , Roberts T.M.
Mol. Cell. Biol.19:2330-2337(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1."
Kruljac-Letunic A. , Moelleken J. , Kallin A. , Wieland F. , Blaukat A.
J. Biol. Chem.278:29560-29570(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-308;INTERACTION WITH PTK2B/PYK2
8.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-732 AND SER-858;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
9.

"Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome."
Inoue H. , Ha V.L. , Prekeris R. , Randazzo P.A.
Mol. Biol. Cell19:4224-4237(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB11FIP3

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