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Index > Protein center > Asap1(Gene name) > Rat
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  • Asap1 (Gene name),
  • Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (Protein name ),  ASAP1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Asap1(Ddef1);
    Protein name:
    Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1;
    Alternative:
    ADP-ribosylation factor-directed GTPase-activating protein 1(ARF GTPase-activating protein 1);130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein;PIP2-dependent ARF1 GAP;Development and differentiation-enhancing factor 1(DEF-1;Differentiation-enhancing factor 1);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3.
    Function:
    Possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis.
    Subcellular Location:
    Cytoplasm Membrane Predominantly cytoplasmic. Partially membrane-associated.
    Protein Attributes:
    Sequence length:
    1144
    Sequence:
    50:
    MRSSASRLSS | FSSRDSLWNR | MPDQISVSEF | IAETTEDYNS | PTTSSFTTRL | 
    100:
    HNCRNTVTLL | EEALDQDRTA | LQKVKKSVKA | IYNSGQDHVQ | NEENYAQVLD | 
    150:
    KFGSNFLSRD | NPDLGTAFVK | FSTLTKELST | LLKNLLQGLS | HNVIFTLDSL | 
    200:
    LKGDLKGVKG | DLKKPFDKAW | KDYEMKFTKI | EKEKREHAKQ | HGMIRTEITG | 
    250:
    AEIAEEMEKE | RRLFQLQMCE | YLIKVNEIKT | KKGVDLLQNL | IKYYHAQCNF | 
    300:
    FQDGLKTADK | LKQYIEKLAA | DLYNIKQTQD | EEKKQLTALR | DLIKSSLQLD | 
    350:
    PKEVGGLYVP | SRANSDSQSR | QGGYSMHQLQ | GNKEYGSEKK | GFLLKKSDGI | 
    400:
    RKVWQRRKCA | VKNGILTISH | ATSNRQPAKL | NLLTCQVKPN | AEDKKSFDLI | 
    450:
    SHNRTYHFQA | EDEQDYVAWI | SVLTNSKEEA | LTMAFRGEQS | TGENSLEDLT | 
    500:
    KAIIEDVQRL | PGNDICCDCG | SSEPTWLSTN | LGILTCIECS | GIHREMGVHI | 
    550:
    SRIQSLELDK | LGTSELLLAK | NVGNNSFNDI | MEANLPSPSP | KPTPSSDMTV | 
    600:
    RKEYITAKYV | DHRFSRKTCA | SSSAKLNELL | EAIKSRDLLA | LIQVYAEGVE | 
    650:
    LMEPLLEPGQ | ELGETALHLA | VRTADQTSLH | LVDFLVQNCG | NLDKQTSVGN | 
    700:
    TVLHYCSMYG | KPECLKLLLR | SKPTVDIVNQ | NGETALDIAK | RLKATQCEDL | 
    750:
    LSQAKSGKFN | PHVHVEYEWN | LRQDEMDESD | DDLDDKPSPI | KKERSPRPQS | 
    800:
    FCHSSSISPQ | DKLALPGFST | PRDKQRLSYG | AFTNQIFVST | STDLPTSPTS | 
    850:
    EAPPLPPRNA | GKGPTGPPST | LPLGTQTSSG | SSTLSKKRSP | PPPPGHKRTL | 
    900:
    SDPPSPLPHG | PPNKGAIPWG | NDVGPSSSSK | TANKFEGLSQ | QASTSSAKTA | 
    950:
    LGPRVLPKLP | QKVALRKTET | SHHLSLDRAN | IPPETFQKSS | QLSELPQKPP | 
    1000:
    LGDLPPKPME | LAPKPQIGEL | PPKPGELPPK | PQLGDLPPKP | QLSDLPPKPQ | 
    1050:
    MKDLPPKPQL | GDLLAKSQAS | DLSAKVQPPS | EVTQRSHTGD | LSPNVQSRDA | 
    1100:
    IQKQASEDSN | DLTPTLPETP | VPLPRKINTG | KNKVRRVKTI | YDCQADNDDE | 
    1144:
    LTFIEGEVII | VTGEEDQEWW | IGHIEGQPER | KGVFPVSFVH | ILSD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    ELISA Kit for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    ELISA Kit for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    ELISA Kit for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    CLIA Kit for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    CLIA Kit for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    CLIA Kit for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    CLIA Kit for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Polyclonal Antibody for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Polyclonal Antibody for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Polyclonal Antibody for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Polyclonal Antibody for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Monoclonal Antibody for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Monoclonal Antibody for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Monoclonal Antibody for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Monoclonal Antibody for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Protein for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Protein for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Protein for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Protein for Rat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

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    References
    1. 1.
      "Enhanced ASAP1 expression is associated with tumor development and progression, and promotes metastasis in experimental tumors."
      Mueller T. , Rothley M. , Bauer M. , Pankraz M. , Sleeman J.
      Submitted (2005-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
      strain: Sprague-Dawley.
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