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Index > Protein center > ASGR1(Gene name) > Human
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  • ASGR1 (Gene name),
  • Asialoglycoprotein receptor 1 (Protein name ),  ASGR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ASGR1(CLEC4H1);
    Protein name:
    Asialoglycoprotein receptor 1(ASGP-R 1;ASGPR 1);
    Alternative:
    Hepatic lectin H1(HL-1);C-type lectin domain family 4 member H1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with LASS2.
    Function:
    Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    291
    Sequence:
    50:
    MTKEYQDLQH | LDNEESDHHQ | LRKGPPPPQP | LLQRLCSGPR | LLLLSLGLSL | 
    100:
    LLLVVVCVIG | SQNSQLQEEL | RGLRETFSNF | TASTEAQVKG | LSTQGGNVGR | 
    150:
    KMKSLESQLE | KQQKDLSEDH | SSLLLHVKQF | VSDLRSLSCQ | MAALQGNGSE | 
    200:
    RTCCPVNWVE | HERSCYWFSR | SGKAWADADN | YCRLEDAHLV | VVTSWEEQKF | 
    250:
    VQHHIGPVNT | WMGLHDQNGP | WKWVDGTDYE | TGFKNWRPEQ | PDDWYGHGLG | 
    291:
    GGEDCAHFTD | DGRWNDDVCQ | RPYRWVCETE | LDKASQEPPL | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    MIM:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human ASGP-R 1
    Cat.:
    E1196h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human ASGP-R 1
    Cat.:
    E1196m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human ASGP-R 1
    Cat.:
    E1196r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human ASGP-R 1
    Cat.:
    U1196h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ASGP-R 1
    Cat.:
    U1196m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ASGP-R 1
    Cat.:
    U1196r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ASGP-R 1
    Cat.:
    P1196Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ASGP-R 1
    Cat.:
    P1196Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ASGP-R 1
    Cat.:
    P1196Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ASGP-R 1
    Monoclonal Antibody for Human ASGP-R 1
    Monoclonal Antibody for Human ASGP-R 1
    Protein for Human ASGP-R 1
    Protein for Human ASGP-R 1
    Protein for Human ASGP-R 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion."
      Spiess M. , Schwartz A.L. , Lodish H.F.
      J. Biol. Chem.260:1979-1982(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H1A)
    2. 2.
      "An internal signal sequence: the asialoglycoprotein receptor membrane anchor."
      Spiess M. , Lodish H.F.
      Cell44:177-185(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H1A)
    3. 3.
      "Human asialoglycoprotein receptor 1 gene is expressed in SH-SY5Y human neuroblastoma cells."
      Wang H. , Gao X. , Li L. , Lou H. , Huang Y. , Wang B. , Han J.
      Submitted (2001-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H1A)
    4. 4.
      "A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes."
      Liu J. , Hu B. , Yang Y. , Ma Z. , Yu Y. , Liu S. , Wang B. , Zhao X. , Lu M. , Yang D.
      PLoS ONE5:E12934-E12934(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H1B);ALTERNATIVE SPLICING;SUBCELLULAR LOCATION (ISOFORM H1B)
      tissue: Liver.
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM H1A)
      tissue: Liver.
    6. 7.
      "Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits."
      Zeng F.Y. , Weigel P.H.
      J. Biol. Chem.271:32454-32460(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-36
    7. 8.
      "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."
      Pan H. , Qin W.-X. , Huo K.-K. , Wan D.-F. , Yu Y. , Xu Z.-G. , Hu Q.-D. , Gu K.T. , Zhou X.-M. , Jiang H.-Q. , Zhang P.-P. , Huang Y. , Li Y.-Y. , Gu J.-R.
      Genomics77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LASS2
    8. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79 AND ASN-147
      tissue: Liver.
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 11.
      "Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor."
      Meier M. , Bider M.D. , Malashkevich V.N. , Spiess M. , Burkhard P.
      J. Mol. Biol.300:857-865(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 154-281
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