Gene name:
ASIC1 (ACCN2;BNAC2) ;
Protein name:
Acid-sensing ion channel 1 (ASIC1) ;
Alternative:
Brain sodium channel 2 (BNaC2) ;Amiloride-sensitive cation channel 2, neuronal ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and ASIC2 (By similarity). Interacts with PRKCABP.
Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.
Protein Attributes:
50:
MELKAEEEEV | GGVQPVSIQA | FASSSTLHGL | AHIFSYERLS | LKRALWALCF |
100:
LGSLAVLLCV | CTERVQYYFH | YHHVTKLDEV | AASQLTFPAV | TLCNLNEFRF |
150:
SQVSKNDLYH | AGELLALLNN | RYEIPDTQMA | DEKQLEILQD | KANFRSFKPK |
200:
PFNMREFYDR | AGHDIRDMLL | SCHFRGEVCS | AEDFKVVFTR | YGKCYTFNSG |
250:
RDGRPRLKTM | KGGTGNGLEI | MLDIQQDEYL | PVWGETDETS | FEAGIKVQIH |
300:
SQDEPPFIDQ | LGFGVAPGFQ | TFVACQEQRL | IYLPPPWGTC | KAVTMDSDLD |
350:
FFDSYSITAC | RIDCETRYLV | ENCNCRMVHM | PGDAPYCTPE | QYKECADPAL |
400:
DFLVEKDQEY | CVCEMPCNLT | RYGKELSMVK | IPSKASAKYL | AKKFNKSEQY |
450:
IGENILVLDI | FFEVLNYETI | EQKKAYEIAG | LLGDIGGQMG | LFIGASILTV |
500:
LELFDYAYEV | IKHKLCRRGK | CQKEAKRSSA | DKGVALSLDD | VKRHNPCESL |
528:
RGHPAGMTYA | ANILPHHPAR | GTFEDFTC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Chicken
Mouse
Human
ELISA Kit for Human ASIC1
ELISA Kit for Human ASIC1
ELISA Kit for Human ASIC1
ELISA Kit for Human ASIC1
Polyclonal Antibody for Human ASIC1
Polyclonal Antibody for Human ASIC1
Polyclonal Antibody for Human ASIC1
Polyclonal Antibody for Human ASIC1
Monoclonal Antibody for Human ASIC1
Monoclonal Antibody for Human ASIC1
Monoclonal Antibody for Human ASIC1
Monoclonal Antibody for Human ASIC1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
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Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION (ISOFORMS 1; 2 AND 3);SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Ovary .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REGULATION BY FMRFAMIDE-RELATED PEPTIDES
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PRKCABP
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY PKA;MUTAGENESIS OF SER-478 AND SER-479;PHOSPHORYLATION AT SER-479;INTERACTION WITH PRKCABP;SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REGULATION BY SERINE PROTEASES
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SPIDER VENOM PSALMOTOXIN;ENZYME REGULATION