Asic1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAsic1 ELISA Kit for Rat(Rattus norvegicus)

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Asic1 (Gene name),

Acid-sensing ion channel 1 (Protein name ), ASIC1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Asic1(Accn2;Bnac2);

Protein name:

Acid-sensing ion channel 1(ASIC1);

Alternative:

Brain sodium channel 2(BNaC2);Amiloride-sensitive cation channel 2, neuronal;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and PRKCABP (By similarity). Interacts with ASIC2.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties.

Subcellular Location:

Cell membrane Multi-pass membrane protein Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.

Protein Attributes:

Sequence length:

526

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

526:

HPAGMTYAAN | ILPHHPARGT | FEDFTC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:79123

Pfam:

PF00858

SMR:

P55926

UniGene:

Rn.37385

Uniprot:

P55926

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ELISA Kit for Rat ASIC1

CLIA Kit for Rat ASIC1

Polyclonal Antibody for Rat ASIC1

Monoclonal Antibody for Rat ASIC1

Protein for Rat ASIC1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"A proton-gated cation channel involved in acid-sensing."
Waldmann R. , Champigny G. , Bassilana F. , Heurteaux C. , Lazdunski M.
Nature386:173-177(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;ENZYME REGULATION
2.

"A sensory neuron-specific, proton-gated ion channel."
Chen C.-C. , England S. , Akopian A.N. , Wood J.N.
Proc. Natl. Acad. Sci. U.S.A.95:10240-10245(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Spinal ganglion.
3.

"Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b."
Baessler E.-L. , Ngo-Anh T.J. , Geisler H.-S. , Ruppersberg J.P. , Gruender S.
J. Biol. Chem.276:33782-33787(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);DOMAIN;FUNCTION
tissue: Inner ear.
4.

"Cloning and functional expression of ASIC-beta2, a splice variant of ASIC-beta."
Ugawa S. , Ueda T. , Takahashi E. , Hirabayashi Y. , Yoneda T. , Komai S. , Shimada S.
NeuroReport12:2865-2869(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;FUNCTION
tissue: Trigeminal ganglion.
5.

"The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties."
Bassilana F. , Champigny G. , Waldmann R. , de Weille J.R. , Heurteaux C. , Lazdunski M.
J. Biol. Chem.272:28819-28822(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH ASIC1;MUTAGENESIS OF GLY-431;FUNCTION
6.

"Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels."
Escoubas P. , de Weille J.R. , Lecoq A. , Diochot S. , Waldmann R. , Champigny G. , Moinier D. , Menez A. , Lazdunski M.
J. Biol. Chem.275:25116-25121(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY PCTX1 TOXIN
7.

"Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."
Askwith C.C. , Cheng C. , Ikuma M. , Benson C. , Price M.P. , Welsh M.J.
Neuron26:133-141(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY FMRFAMIDE-RELATED PEPTIDES
8.

"Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors."
Voilley N. , de Weille J.R. , Mamet J. , Lazdunski M.
J. Neurosci.21:8026-8033(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;INHIBITION BY DRUGS
9.

"Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1)."
Babini E. , Paukert M. , Geisler H.-S. , Gruender S.
J. Biol. Chem.277:41597-41603(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF PHE-100; VAL-103; LYS-105 AND ASN-106;FUNCTION
10.

"Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system."
Alvarez de la Rosa D. , Zhang P. , Shao D. , White F. , Canessa C.M.
Proc. Natl. Acad. Sci. U.S.A.99:2326-2331(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
11.

"The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1."
Coric T. , Zhang P. , Todorovic N. , Canessa C.M.
J. Biol. Chem.278:45240-45247(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-83; GLN-84; LEU-85 AND 128-GLN--ASP-131
12.

"Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels."
Xiong Z.-G. , Zhu X.-M. , Chu X.-P. , Minami M. , Hey J. , Wei W.-L. , MacDonald J.F. , Wemmie J.A. , Price M.P. , Welsh M.J. , Simon R.P.
Cell118:687-698(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating."
Paukert M. , Babini E. , Pusch M. , Grunder S.
J. Gen. Physiol.124:383-394(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLU-425; ASP-432 AND GLN-436

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