Asic2 ELISA Kit for Mouse(Mus musculus) | EIAab.comAsic2 ELISA Kit for Mouse(Mus musculus)

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Asic2 (Gene name),

Acid-sensing ion channel 2 (Protein name ), ASIC2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Asic2(Accn1;Bnac1);

Protein name:

Acid-sensing ion channel 2(ASIC2);

Alternative:

Amiloride-sensitive cation channel 1, neuronal;Amiloride-sensitive brain sodium channel;Brain sodium channel 1(BNC1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with PRKCABP and ASIC3 (By similarity). Interacts with STOM.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Subcellular Location:

Cell membrane Multi-pass membrane protein Localized at the plasma membrane, in the soma and punctated peripheral processes of neurons.

Protein Attributes:

Sequence length:

512

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

512:

QTALGTLEEI | AC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00858

UniGene:

Mm.234998

KEGG:

mmu:11418

SMR:

Q925H0

Uniprot:

Q925H0

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ELISA Kit for Mouse ASIC2

CLIA Kit for Mouse ASIC2

Polyclonal Antibody for Mouse ASIC2

Monoclonal Antibody for Mouse ASIC2

Protein for Mouse ASIC2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells."
Lingueglia E. , de Weille J.R. , Bassilana F. , Heurteaux C. , Sakai H. , Waldmann R. , Lazdunski M.
J. Biol. Chem.272:29778-29783(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: BALB/c.
tissue: Brain.
2.

"Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons."
Garcia-Anoveros J. , Samad T.A. , Zuvela-Jelaska L. , Woolf C.J. , Corey D.P.
J. Neurosci.21:2678-2686(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: BALB/c.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"Stomatin modulates gating of acid-sensing ion channels."
Price M.P. , Thompson R.J. , Eshcol J.O. , Wemmie J.A. , Benson C.J.
J. Biol. Chem.279:53886-53891(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STOM
5.

"Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration."
Ettaiche M. , Guy N. , Hofman P. , Lazdunski M. , Waldmann R.
J. Neurosci.24:1005-1012(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION;DISRUPTION PHENOTYPE
6.

"Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice."
Peng B.-G. , Ahmad S. , Chen S. , Chen P. , Price M.P. , Lin X.
J. Neurosci.24:10167-10175(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
7.

"The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability."
McIlwrath S.L. , Hu J. , Anirudhan G. , Shin J.-B. , Lewin G.R.
Neuroscience131:499-511(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION BY NEUROTROPHIN
8.

"A stomatin dimer modulates the activity of acid-sensing ion channels."
Brand J. , Smith E.S. , Schwefel D. , Lapatsina L. , Poole K. , Omerbasic D. , Kozlenkov A. , Behlke J. , Lewin G.R. , Daumke O.
EMBO J.31:3635-3646(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STOM

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