Asic3 ELISA Kit for Mouse(Mus musculus) | EIAab.comAsic3 ELISA Kit for Mouse(Mus musculus)

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Asic3 (Gene name),

Acid-sensing ion channel 3 (Protein name ), ASIC3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Asic3(Accn3;Drasic);

Protein name:

Acid-sensing ion channel 3(ASIC3);

Alternative:

Dorsal root ASIC(DRASIC);Amiloride-sensitive cation channel 3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM, DLG4 and ASIC2 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1 and GOPC.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cytoplasm Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4 (By similarity). In part cytoplasmic in cochlea cells.

Protein Attributes:

Sequence length:

530

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

530:

SLGPRPPTAP | SAVTKTLAAS | HRTCYLVTRL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00858

KEGG:

mmu:171209

UniGene:

Mm.299636

SMR:

Q6X1Y6

STRING:

10090.ENSMUSP00000039914

Uniprot:

Q6X1Y6

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ELISA Kit for Mouse ASIC3

Cat.:

E16230h

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Manual:

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96T

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ELISA Kit for Mouse ASIC3

Cat.:

E16230r

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96T

ELISA Kit for Mouse ASIC3

Cat.:

E16230m

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96T

CLIA Kit for Mouse ASIC3

Cat.:

U16230r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse ASIC3

Cat.:

U16230h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse ASIC3

Cat.:

U16230m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse ASIC3

Cat.:

P16230Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse ASIC3

Cat.:

P16230Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse ASIC3

Cat.:

P16230Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse ASIC3

Protein for Mouse ASIC3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Characterisation of DRASIC in the mouse inner ear."
Hildebrand M.S. , de Silva M.G. , Klockars T. , Rose E. , Price M. , Smith R.J.H. , McGuirt W.T. , Christopoulos H. , Petit C. , Dahl H.-H.M.
Hear. Res.190:149-160(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
tissue: Inner ear.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."
Askwith C.C. , Cheng C. , Ikuma M. , Benson C. , Price M.P. , Welsh M.J.
Neuron26:133-141(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY FMRFAMIDE-RELATED PEPTIDES
4.

"The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice."
Price M.P. , McIlwrath S.L. , Xie J. , Cheng C. , Qiao J. , Tarr D.E. , Sluka K.A. , Brennan T.J. , Lewin G.R. , Welsh M.J.
Neuron32:1071-1083(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
5.

"A role for ASIC3 in the modulation of high-intensity pain stimuli."
Chen C.-C. , Zimmer A. , Sun W.-H. , Hall J. , Brownstein M.J. , Zimmer A.
Proc. Natl. Acad. Sci. U.S.A.99:8992-8997(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1."
Sluka K.A. , Price M.P. , Breese N.M. , Stucky C.L. , Wemmie J.A. , Welsh M.J.
Pain106:229-239(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
7.

"PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."
Hruska-Hageman A.M. , Benson C.J. , Leonard A.S. , Price M.P. , Welsh M.J.
J. Biol. Chem.279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIN7B; MAGI1; GOPC AND DLG4
8.

"Stomatin modulates gating of acid-sensing ion channels."
Price M.P. , Thompson R.J. , Eshcol J.O. , Wemmie J.A. , Benson C.J.
J. Biol. Chem.279:53886-53891(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STOM
9.

"A stomatin dimer modulates the activity of acid-sensing ion channels."
Brand J. , Smith E.S. , Schwefel D. , Lapatsina L. , Poole K. , Omerbasic D. , Kozlenkov A. , Behlke J. , Lewin G.R. , Daumke O.
EMBO J.31:3635-3646(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STOM

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