Asic3 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAsic3 ELISA Kit for Rat(Rattus norvegicus)

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Asic3 (Gene name),

Acid-sensing ion channel 3 (Protein name ), ASIC3_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Asic3(Accn3;Drasic);

Protein name:

Acid-sensing ion channel 3(ASIC3);

Alternative:

Dorsal root ASIC(DRASIC);Amiloride-sensitive cation channel 3;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM, LIN7B, MAGI1 and GOPC (By similarity). Interacts with DLG4 and ASIC2.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Subcellular Location:

Cytoplasm Cell membrane Multi-pass membrane protein In part cytoplasmic in cochlea cells (By similarity). Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4.

Protein Attributes:

Sequence length:

533

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

533:

PHLSLGPRPP | TTPCAVTKTL | SASHRTCYLV | TRL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00858

KEGG:

rno:286920

STRING:

10116.ENSRNOP00000011300

UniGene:

Rn.24225

SMR:

O35240

Uniprot:

O35240

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ELISA Kit for Rat ASIC3

Cat.:

E16230h

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96T

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ELISA Kit for Rat ASIC3

Cat.:

E16230r

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96T

ELISA Kit for Rat ASIC3

Cat.:

E16230m

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96T

CLIA Kit for Rat ASIC3

Cat.:

U16230r

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Packing:

96T

CLIA Kit for Rat ASIC3

Cat.:

U16230h

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Packing:

96T

CLIA Kit for Rat ASIC3

Cat.:

U16230m

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Packing:

96T

Polyclonal Antibody for Rat ASIC3

Cat.:

P16230Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat ASIC3

Cat.:

P16230Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat ASIC3

Cat.:

P16230Rb-r

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40ug/0.2ml

Monoclonal Antibody for Rat ASIC3

Protein for Rat ASIC3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons."
Waldmann R. , Bassilana F. , de Weille J.R. , Champigny G. , Heurteaux C. , Lazdunski M.
J. Biol. Chem.272:20975-20978(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
2.

"A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells."
Lingueglia E. , de Weille J.R. , Bassilana F. , Heurteaux C. , Sakai H. , Waldmann R. , Lazdunski M.
J. Biol. Chem.272:29778-29783(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASIC1
strain: Wistar.
tissue: Brain.
3.

"A sensory neuron-specific, proton-gated ion channel."
Chen C.-C. , England S. , Akopian A.N. , Wood J.N.
Proc. Natl. Acad. Sci. U.S.A.95:10240-10245(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
4.

"The pre-transmembrane 1 domain of acid-sensing ion channels participates in the ion pore."
Coscoy S. , de Weille J.R. , Lingueglia E. , Lazdunski M.
J. Biol. Chem.274:10129-10132(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF VAL-20; PHE-21 AND THR-26
5.

"Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+."
Babinski K. , Catarsi S. , Biagini G. , Seguela P.
J. Biol. Chem.275:28519-28525(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors."
Voilley N. , de Weille J.R. , Mamet J. , Lazdunski M.
J. Neurosci.21:8026-8033(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;INHIBITION BY DRUGS
7.

"Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons."
Immke D.C. , McCleskey E.W.
Nat. Neurosci.4:869-870(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY LACTATE;FUNCTION
8.

"Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF."
Catarsi S. , Babinski K. , Seguela P.
Neuropharmacology41:592-600(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY NPFF
9.

"Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons."
Sutherland S.P. , Benson C.J. , Adelman J.P. , McCleskey E.W.
Proc. Natl. Acad. Sci. U.S.A.98:711-716(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels."
Mamet J. , Baron A. , Lazdunski M. , Voilley N.
J. Neurosci.22:10662-10670(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
11.

"Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system."
Alvarez de la Rosa D. , Zhang P. , Shao D. , White F. , Canessa C.M.
Proc. Natl. Acad. Sci. U.S.A.99:2326-2331(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
12.

"How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons."
Mamet J. , Lazdunski M. , Voilley N.
J. Biol. Chem.278:48907-48913(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;INDUCTION BY NGFB
13.

"Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade."
Immke D.C. , McCleskey E.W.
Neuron37:75-84(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY LACTATE AND CALCIUM
14.

"Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability."
Deval E. , Baron A. , Lingueglia E. , Mazarguil H. , Zajac J.-M. , Lazdunski M.
Neuropharmacology44:662-671(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons."
Diochot S. , Baron A. , Rash L.D. , Deval E. , Escoubas P. , Scarzello S. , Salinas M. , Lazdunski M.
EMBO J.23:1516-1525(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY APETX2 TOXIN
16.

"ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1."
Deval E. , Salinas M. , Baron A. , Lingueglia E. , Lazdunski M.
J. Biol. Chem.279:19531-19539(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THR-40 AND SER-523;PHOSPHORYLATION AT THR-40 AND SER-523
17.

"PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."
Hruska-Hageman A.M. , Benson C.J. , Leonard A.S. , Price M.P. , Welsh M.J.
J. Biol. Chem.279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLG4;SUBCELLULAR LOCATION
18.

"A stomatin dimer modulates the activity of acid-sensing ion channels."
Brand J. , Smith E.S. , Schwefel D. , Lapatsina L. , Poole K. , Omerbasic D. , Kozlenkov A. , Behlke J. , Lewin G.R. , Daumke O.
EMBO J.31:3635-3646(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STOM;SUBCELLULAR LOCATION

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