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Index > Protein center > ASIP(Gene name) > Dog
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  • ASIP (Gene name),
  • Agouti-signaling protein (Protein name ),  ASIP_CANFA from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ASIP;
    Protein name:
    Agouti-signaling protein(ASP);
    Alternative:
    Agouti switch protein;
    Organism:
    Dog (Canis familiarisCanis lupus familiaris). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    131
    Sequence:
    50:
    MNIFRLLLAT | LLVSLCFLTA | YSHLAEEKPK | DDRSLRSNSS | VNLLDFPSVS | 
    100:
    IVALNKKSKK | ISRKEAEKKR | SSKKKASMKN | VARPRPPPPT | PCVATRNSCK | 
    131:
    SPAPACCDPC | ASCQCRFFRS | ACTCRVLSPR | C
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Dog ASP
    ELISA Kit for Dog ASP
    ELISA Kit for Dog ASP
    ELISA Kit for Dog ASP
    ELISA Kit for Dog ASP
    ELISA Kit for Dog ASP
    CLIA Kit for Dog ASP
    CLIA Kit for Dog ASP
    CLIA Kit for Dog ASP
    CLIA Kit for Dog ASP
    CLIA Kit for Dog ASP
    CLIA Kit for Dog ASP
    Polyclonal Antibody for Dog ASP
    Polyclonal Antibody for Dog ASP
    Polyclonal Antibody for Dog ASP
    Polyclonal Antibody for Dog ASP
    Polyclonal Antibody for Dog ASP
    Polyclonal Antibody for Dog ASP
    Monoclonal Antibody for Dog ASP
    Monoclonal Antibody for Dog ASP
    Monoclonal Antibody for Dog ASP
    Monoclonal Antibody for Dog ASP
    Monoclonal Antibody for Dog ASP
    Monoclonal Antibody for Dog ASP
    Protein for Dog ASP
    Protein for Dog ASP
    Protein for Dog ASP
    Protein for Dog ASP
    Protein for Dog ASP
    Protein for Dog ASP

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    References
    1. 1.
      "Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd dogs."
      Kerns J.A. , Newton J. , Berryere T.G. , Rubin E.M. , Cheng J.F. , Schmutz S.M. , Barsh G.S.
      Mamm. Genome15:798-808(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT CYS-96
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