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Index > Protein center > ASXL2(Gene name) > Human
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  • ASXL2 (Gene name),
  • Putative Polycomb group protein ASXL2 (Protein name ),  ASXL2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ASXL2(ASXH2;KIAA1685);
    Protein name:
    Putative Polycomb group protein ASXL2;
    Alternative:
    Additional sex combs-like protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1435
    Sequence:
    50:
    MREKGRRKKG | RTWAEAAKTV | LEKYPNTPMS | HKEILQVIQR | EGLKEIRSGT | 
    100:
    SPLACLNAML | HTNSRGEEGI | FYKVPGRMGV | YTLKKDVPDG | VKELSEGSEE | 
    150:
    SSDGQSDSQS | SENSSSSSDG | GSNKEGKKSR | WKRKVSSSSP | QSGCPSPTIP | 
    200:
    AGKVISPSQK | HSKKALKQAL | KQQQQKKQQQ | QCRPSISISS | NQHLSLKTVK | 
    250:
    AASDSVPAKP | ATWEGKQSDG | QTGSPQNSNS | SFSSSVKVEN | TLLGLGKKSF | 
    300:
    QRSERLHTRQ | MKRTKCADID | VETPDSILVN | TNLRALINKH | TFSVLPGDCQ | 
    350:
    QRLLLLLPEV | DRQVGPDGLM | KLNGSALNNE | FFTSAAQGWK | ERLSEGEFTP | 
    400:
    EMQVRIRQEI | EKEKKVEPWK | EQFFESYYGQ | SSGLSLEDSK | KLTASPSDPK | 
    450:
    VKKTPAEQPK | SMPVSEASLI | RIVPVVSQSE | CKEEALQMSS | PGRKEECESQ | 
    500:
    GEVQPNFSTS | SEPLLSSALN | THELSSILPI | KCPKDEDLLE | QKPVTSAEQE | 
    550:
    SEKNHLTTAS | NYNKSESQES | LVTSPSKPKS | PGVEKPIVKP | TAGAGPQETN | 
    600:
    MKEPLATLVD | QSPESLKRKS | SLTQEEAPVS | WEKRPRVTEN | RQHQQPFQVS | 
    650:
    PQPFLNRGDR | IQVRKVPPLK | IPVSRISPMP | FHPSQVSPRA | RFPVSITSPN | 
    700:
    RTGARTLADI | KAKAQLVKAQ | RAAAAAAAAA | AAAASVGGTI | PGPGPGGGQG | 
    750:
    PGEGGEGQTA | RGGSPGSDRV | SETGKGPTLE | LAGTGSRGGT | RELLPCGPET | 
    800:
    QPQSETKTTP | SQAQPHSVSG | AQLQQTPPVP | PTPAVSGACT | SVPSPAHIEK | 
    850:
    LDNEKLNPTR | ATATVASVSH | PQGPSSCRQE | KAPSPTGPAL | ISGASPVHCA | 
    900:
    ADGTVELKAG | PSKNIPNPSA | SSKTDASVPV | AVTPSPLTSL | LTTATLEKLP | 
    950:
    VPQVSATTAP | AGSAPPSSTL | PAASSLKTPG | TSLNMNGPTL | RPTSSIPANN | 
    1000:
    PLVTQLLQGK | DVPMEQILPK | PLTKVEMKTV | PLTAKEERGM | GALIATNTTE | 
    1050:
    NSTREEVNER | QSHPATQQQL | GKTLQSKQLP | QVPRPLQLFS | AKELRDSSID | 
    1100:
    THQYHEGLSK | ATQDQILQTL | IQRVRRQNLL | SVVPPSQFNF | AHSGFQLEDI | 
    1150:
    STSQRFMLGF | AGRRTSKPAM | AGHYLLNIST | YGRGSESFRR | THSVNPEDRF | 
    1200:
    CLSSPTEALK | MGYTDCKNAT | GESSSSKEDD | TDEESTGDEQ | ESVTVKEEPQ | 
    1250:
    VSQSAGKGDT | SSGPHSRETL | STSDCLASKN | VKAEIPLNEQ | TTLSKENYLF | 
    1300:
    TRGQTFDEKT | LARDLIQAAQ | KQMAHAVRGK | AIRSSPELFS | STVLPLPADS | 
    1350:
    PTHQPLLLPP | LQTPKLYGSP | TQIGPSYRGM | INVSTSSDMD | HNSAVPGSQV | 
    1400:
    SSNVGDVMSF | SVTVTTIPAS | QAMNPSSHGQ | TIPVQAFSEE | NSIEGTPSKC | 
    1435:
    YCRLKAMIMC | KGCGAFCHDD | CIGPSKLCVS | CLVVR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Putative Polycomb group protein ASXL2
    ELISA Kit for Human Putative Polycomb group protein ASXL2
    ELISA Kit for Human Putative Polycomb group protein ASXL2
    CLIA Kit for Human Putative Polycomb group protein ASXL2
    CLIA Kit for Human Putative Polycomb group protein ASXL2
    CLIA Kit for Human Putative Polycomb group protein ASXL2
    Polyclonal Antibody for Human Putative Polycomb group protein ASXL2
    Polyclonal Antibody for Human Putative Polycomb group protein ASXL2
    Polyclonal Antibody for Human Putative Polycomb group protein ASXL2
    Monoclonal Antibody for Human Putative Polycomb group protein ASXL2
    Monoclonal Antibody for Human Putative Polycomb group protein ASXL2
    Monoclonal Antibody for Human Putative Polycomb group protein ASXL2
    Protein for Human Putative Polycomb group protein ASXL2
    Protein for Human Putative Polycomb group protein ASXL2
    Protein for Human Putative Polycomb group protein ASXL2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "MOZ is fused to a novel Polycomb group gene in a therapy-related myelodysplastic syndrome with t(2;8)(p23;p11.2)."
      Hosoda F. , Kitabayashi I. , Kakazu N. , Fukushima M. , Aikawa Y. , Abe T. , Hibi S. , Yagi T. , Ohki M.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHROMOSOMAL TRANSLOCATION WITH KAT6A
      tissue: Bone marrow.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Hattori A. , Kondo Y. , Okumura K. , Ohara O.
      DNA Res.7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      Ohara O. , Nagase T. , Kikuno R.
      Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT VAL-796
      tissue: Testis.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 890-1435 (ISOFORM 1)
    8. 8.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      "Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}."
      Park U.H. , Yoon S.K. , Park T. , Kim E.J. , Um S.J.
      J. Biol. Chem.286:1354-1363(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPARA AND PPARG
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