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Index > Protein center > Atp12a(Gene name) > Rat
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  • Atp12a (Gene name),
  • Potassium-transporting ATPase alpha chain 2 (Protein name ),  AT12A_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Atp12a(Atp1al1);
    Protein name:
    Potassium-transporting ATPase alpha chain 2;
    Alternative:
    Proton pump;Non-gastric H(+)/K(+) ATPase subunit alpha;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Composed of two subunits: alpha (catalytic) and beta.
    Function:
    Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1036
    Sequence:
    50:
    MRRKTEIYSV | ELNGTKDVKP | ADQRDDKKFK | GAKNKDLEPN | KSHEKEELKK | 
    100:
    ELDLDDHRLS | NTELEQKYGT | NIIQGLSSVR | ATELLARDGP | NTLTPPKQTP | 
    150:
    EIIKFLKQMV | GGFSILLWIG | AALCWIAFVI | QYVNNSASLD | NVYLGAILVL | 
    200:
    VVILTGIFAY | YQEAKSTNIM | ASFSKMIPQQ | ALVIRDAEKK | VISAEQLVVG | 
    250:
    DVVEIKGGDQ | IPADIRLVFS | QGCKVDNSSL | TGESEPQARS | TEFTHENPLE | 
    300:
    TKNIGFYSTT | CLEGTATGIV | INTGDRTIIG | RIASLASGVG | SEKTPIAIEI | 
    350:
    EHFVHIVAGV | AVSIDIIFFI | TAVCMKYYVL | DAIIFLISII | VANVPEGLLA | 
    400:
    TVTVTLSLTA | KRMAKKNCLV | KNLEAVETLG | STSIICSDKT | GTLTQNRMTV | 
    450:
    AHLWFDNQIF | VADTSENQTK | QAFDQSSGTW | ASLSKIITLC | NRAEFRPGQE | 
    500:
    SVPIMKRTVV | GDASETALLK | FSEVILGDVM | GIRKRNHKVA | EIPFNSTNKF | 
    550:
    QLSIHETEDP | NNKRFLVVMK | GAPERILEKC | STIMINGQEQ | PLDKSSADSF | 
    600:
    HTAYMELGGL | GERVLGFCHL | YLPAEQFPQS | YIFDVDSVNF | PTSNFCFVGL | 
    650:
    LSMIDPPRST | VPDAVSKCRS | AGIKVIMVTG | DHPITAKAIA | KSVGIISANN | 
    700:
    ETVEDIAKRR | NIAVEQVNKR | EAKAAVVTGM | ELKDMTPEQL | DELLTNYQEI | 
    750:
    VFARTSPQQK | LIIVEGCQRQ | DAIVAVTGDG | VNDSPALKKA | DIGIAMGIAG | 
    800:
    SDAAKNAADM | VLLDDNFASI | VTGVEEGRLI | FDNLKKTIAY | TLTKNIAELC | 
    850:
    PFLIYIVAGL | PLPIGTITIL | FIDLGTDIIP | SIALAYEKAE | SDIMNRKPRH | 
    900:
    KKKDRLVNTQ | LAIYSYLHIG | LMQALGGFLV | YFTVYAQQGF | WPTSLINLRV | 
    950:
    AWETDDINDL | EDSYGQEWTR | YQRKYLEWTG | STAFFVAIMI | QQIADLIIRK | 
    1000:
    TRRNSIFQQG | LFRNKVIWVG | IASQVIVALI | LSYGLGSVPA | LSFTMLRVQY | 
    1036:
    WFVAVPHAIL | IWVYDEMRKL | FIRLYPGSWW | DKNMYY
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Potassium-transporting ATPase alpha chain 2
    ELISA Kit for Rat Potassium-transporting ATPase alpha chain 2
    ELISA Kit for Rat Potassium-transporting ATPase alpha chain 2
    ELISA Kit for Rat Potassium-transporting ATPase alpha chain 2
    CLIA Kit for Rat Potassium-transporting ATPase alpha chain 2
    CLIA Kit for Rat Potassium-transporting ATPase alpha chain 2
    CLIA Kit for Rat Potassium-transporting ATPase alpha chain 2
    CLIA Kit for Rat Potassium-transporting ATPase alpha chain 2
    Polyclonal Antibody for Rat Potassium-transporting ATPase alpha chain 2
    Polyclonal Antibody for Rat Potassium-transporting ATPase alpha chain 2
    Polyclonal Antibody for Rat Potassium-transporting ATPase alpha chain 2
    Polyclonal Antibody for Rat Potassium-transporting ATPase alpha chain 2
    Monoclonal Antibody for Rat Potassium-transporting ATPase alpha chain 2
    Monoclonal Antibody for Rat Potassium-transporting ATPase alpha chain 2
    Monoclonal Antibody for Rat Potassium-transporting ATPase alpha chain 2
    Monoclonal Antibody for Rat Potassium-transporting ATPase alpha chain 2
    Protein for Rat Potassium-transporting ATPase alpha chain 2
    Protein for Rat Potassium-transporting ATPase alpha chain 2
    Protein for Rat Potassium-transporting ATPase alpha chain 2
    Protein for Rat Potassium-transporting ATPase alpha chain 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus."
      Crowson M.S. , Shull G.E.
      J. Biol. Chem.267:13740-13748(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM LONG)
      strain: Sprague-Dawley.
      tissue: Colon.
    2. 2.
      "A novel N-terminal splice variant of the rat H+-K+-ATPase alpha2 subunit. Cloning, functional expression, and renal adaptive response to chronic hypokalemia."
      Kone B.C. , Higham S.C.
      J. Biol. Chem.273:2543-2552(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LONG AND SHORT)
      strain: Sprague-Dawley.
      tissue: Kidney.
    3. 3.
      Lubec G. , Kang S.U.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 779-785;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Brain.
    4. 4.
      "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit."
      Pestov N.B. , Romanova L.G. , Korneenko T.V. , Egorov M.V. , Kostina M.B. , Sverdlov V.E. , Askari A. , Shakhparonov M.I. , Modyanov N.N.
      FEBS Lett.440:320-324(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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