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Index > Protein center > ATP1A4(Gene name) > Human
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  • ATP1A4 (Gene name),
  • Sodium/potassium-transporting ATPase subunit alpha-4 (Protein name ),  AT1A4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ATP1A4(ATP1AL2);
    Protein name:
    Sodium/potassium-transporting ATPase subunit alpha-4(Na(+)/K(+) ATPase alpha-4 subunit);
    Alternative:
    Sodium pump subunit alpha-4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Composed of three subunits: alpha (catalytic), beta and gamma.
    Function:
    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein In mature sperm, located in the principle piece of the sperm flagellum.
    Protein Attributes:
    Sequence length:
    1029
    Sequence:
    50:
    MGLWGKKGTV | APHDQSPRRR | PKKGLIKKKM | VKREKQKRNM | EELKKEVVMD | 
    100:
    DHKLTLEELS | TKYSVDLTKG | HSHQRAKEIL | TRGGPNTVTP | PPTTPEWVKF | 
    150:
    CKQLFGGFSL | LLWTGAILCF | VAYSIQIYFN | EEPTKDNLYL | SIVLSVVVIV | 
    200:
    TGCFSYYQEA | KSSKIMESFK | NMVPQQALVI | RGGEKMQINV | QEVVLGDLVE | 
    250:
    IKGGDRVPAD | LRLISAQGCK | VDNSSLTGES | EPQSRSPDFT | HENPLETRNI | 
    300:
    CFFSTNCVEG | TARGIVIATG | DSTVMGRIAS | LTSGLAVGQT | PIAAEIEHFI | 
    350:
    HLITVVAVFL | GVTFFALSLL | LGYGWLEAII | FLIGIIVANV | PEGLLATVTV | 
    400:
    CLTLTAKRMA | RKNCLVKNLE | AVETLGSTST | ICSDKTGTLT | QNRMTVAHMW | 
    450:
    FDMTVYEADT | TEEQTGKTFT | KSSDTWFMLA | RIAGLCNRAD | FKANQEILPI | 
    500:
    AKRATTGDAS | ESALLKFIEQ | SYSSVAEMRE | KNPKVAEIPF | NSTNKYQMSI | 
    550:
    HLREDSSQTH | VLMMKGAPER | ILEFCSTFLL | NGQEYSMNDE | MKEAFQNAYL | 
    600:
    ELGGLGERVL | GFCFLNLPSS | FSKGFPFNTD | EINFPMDNLC | FVGLISMIDP | 
    650:
    PRAAVPDAVS | KCRSAGIKVI | MVTGDHPITA | KAIAKGVGII | SEGTETAEEV | 
    700:
    AARLKIPISK | VDASAAKAIV | VHGAELKDIQ | SKQLDQILQN | HPEIVFARTS | 
    750:
    PQQKLIIVEG | CQRLGAVVAV | TGDGVNDSPA | LKKADIGIAM | GISGSDVSKQ | 
    800:
    AADMILLDDN | FASIVTGVEE | GRLIFDNLKK | SIMYTLTSNI | PEITPFLMFI | 
    850:
    ILGIPLPLGT | ITILCIDLGT | DMVPAISLAY | ESAESDIMKR | LPRNPKTDNL | 
    900:
    VNHRLIGMAY | GQIGMIQALA | GFFTYFVILA | ENGFRPVDLL | GIRLHWEDKY | 
    950:
    LNDLEDSYGQ | QWTYEQRKVV | EFTCQTAFFV | TIVVVQWADL | IISKTRRNSL | 
    1000:
    FQQGMRNKVL | IFGILEETLL | AAFLSYTPGM | DVALRMYPLK | ITWWLCAIPY | 
    1029:
    SILIFVYDEI | RKLLIRQHPD | GWVERETYY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    Pfam:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-4 subunit
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-4 subunit
    ELISA Kit for Human Na(+)/K(+) ATPase alpha-4 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-4 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-4 subunit
    CLIA Kit for Human Na(+)/K(+) ATPase alpha-4 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-4 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-4 subunit
    Polyclonal Antibody for Human Na(+)/K(+) ATPase alpha-4 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-4 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-4 subunit
    Monoclonal Antibody for Human Na(+)/K(+) ATPase alpha-4 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-4 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-4 subunit
    Protein for Human Na(+)/K(+) ATPase alpha-4 subunit

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm."
      Hlivko J.T. , Chakraborty S. , Hlivko T.J. , Sengupta A. , James P.F.
      Mol. Reprod. Dev.73:101-115(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;ENZYME REGULATION
      tissue: Testis.
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Testis.
      tissue: Urinary bladder.
    4. 4.
      "Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4."
      Keryanov S. , Gardner K.L.
      Gene292:151-166(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69 AND 138-1029 (ISOFORM 1)
    5. 5.
      "A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis."
      Shamraj O.I. , Lingrel J.B.
      Proc. Natl. Acad. Sci. U.S.A.91:12952-12956(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-220 (ISOFORM 1);VARIANT ASP-83
      tissue: Testis.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1017 (ISOFORM 1)
      tissue: Trachea.
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